TNS1 tensin 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TNS1provided by HGNC
Official Full Name: tensin 1provided by HGNC
Primary source: HGNC:HGNC:11973
See related: Ensembl:ENSG00000079308 MIM:600076; AllianceGenome:HGNC:11973
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TNS; MXRA6; MST091; MST122; MST127; MSTP091; MSTP122; MSTP127; PPP1R155
Summary: The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Expression: Broad expression in fat (RPKM 95.5), lung (RPKM 38.8) and 21 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2q35

Exon count:: 48

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (217799791..218033982, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (218283109..218495456, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (218664514..218867718, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tensin 1 regulated by hepatic leukemia factor represses the progression of prostate cancer.
Title: Tensin 1 regulated by hepatic leukemia factor represses the progression of prostate cancer.
lncRNA ZNRD1-AS1 promotes malignant lung cell proliferation, migration, and angiogenesis via the miR-942/TNS1 axis and is positively regulated by the m[6]A reader YTHDC2.
Title: lncRNA ZNRD1-AS1 promotes malignant lung cell proliferation, migration, and angiogenesis via the miR-942/TNS1 axis and is positively regulated by the m(6)A reader YTHDC2.
Tensin Regulates Fundamental Biological Processes by Interacting with Integrins of Tonsil-Derived Mesenchymal Stem Cells.
Title: Tensin Regulates Fundamental Biological Processes by Interacting with Integrins of Tonsil-Derived Mesenchymal Stem Cells.
miR-31-5p modulates cell progression in lung adenocarcinoma through TNS1/p53 axis.
Title: miR-31-5p modulates cell progression in lung adenocarcinoma through TNS1/p53 axis.
Tensin 1 (TNS1) is a modifier gene for low body mass index (BMI) in homozygous [F508del]CFTR patients.
Title: Tensin 1 (TNS1) is a modifier gene for low body mass index (BMI) in homozygous [F508del]CFTR patients.
miR-152/TNS1 axis inhibits non-small cell lung cancer progression through Akt/mTOR/RhoA pathway.
Title: miR-152/TNS1 axis inhibits non-small cell lung cancer progression through Akt/mTOR/RhoA pathway.
LncRNA MAGI2-AS3 inhibits bladder cancer progression by targeting the miR-31-5p/TNS1 axis.
Title: LncRNA MAGI2-AS3 inhibits bladder cancer progression by targeting the miR-31-5p/TNS1 axis.
MaTAR25 lncRNA regulates the Tensin1 gene to impact breast cancer progression.
Title: MaTAR25 lncRNA regulates the Tensin1 gene to impact breast cancer progression.
Tensin1 expression and function in chronic obstructive pulmonary disease.
Title: Tensin1 expression and function in chronic obstructive pulmonary disease.
Hyperactivity of Mek in TNS1 knockouts leads to potential treatments for cystic kidney diseases.
Title: Hyperactivity of Mek in TNS1 knockouts leads to potential treatments for cystic kidney diseases.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies five loci associated with lung function. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. EBI GWAS Catalog EBI GWAS CatalogPubMed
Hundreds of variants clustered in genomic loci and biological pathways affect human height. EBI GWAS Catalog EBI GWAS CatalogPubMed
Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. EBI GWAS Catalog EBI GWAS CatalogPubMed
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2S173 (e-PCR), detects polymorphism
- UniSTS:44805

D2S2814 (e-PCR)
- UniSTS:3592

SHGC-58428 (e-PCR)
- UniSTS:27920

D2S94 (e-PCR)
- UniSTS:146973

SHGC-79126 (e-PCR)
- UniSTS:95818

D2S2249 (e-PCR)
- UniSTS:51283

D2S1528E (e-PCR)
- UniSTS:150619

SHGC-82607 (e-PCR)
- UniSTS:100725

RH102642 (e-PCR)
- UniSTS:96976

D2S173 (e-PCR), detects polymorphism
- UniSTS:25310

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables actin binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell-substrate junction assembly	IEA Inferred from Electronic Annotation more info
involved_in fibroblast migration	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	HDA more info	PubMed
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tensin-1

Names: Matrix-remodelling-associated protein 6; matrix-remodelling associated 6; protein phosphatase 1, regulatory subunit 155

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001308022.2 → NP_001294951.1 tensin-1 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks in-frame exon in the central coding region, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AB209238, AC009469, AF225896, AK300345, AK309785, BC051304, BC116187, BC116188, BQ045472

Consensus CDS

CCDS77529.1

UniProtKB/TrEMBL

E9PF55, Q0VG55

Related

ENSP00000408724.1, ENST00000419504.6

Conserved Domains (4) summary

cd09927
Location:1446 → 1560

SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins

smart00404
Location:77 → 192

PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif

cd01213
Location:1582 → 1715

PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

pfam10409
Location:179 → 305

PTEN_C2; C2 domain of PTEN tumour-suppressor protein
NM_001308023.2 → NP_001294952.1 tensin-1 isoform 3

See identical proteins and their annotated locations for NP_001294952.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, and lacks two consecutive in-frame exons in the central coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AC009469

Consensus CDS

CCDS77528.1

UniProtKB/TrEMBL

A0A087WWW7, E9PGF5, Q0VG54

Related

ENSP00000480559.2, ENST00000615025.6

Conserved Domains (4) summary

cd09927
Location:1438 → 1553

SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins

smart00404
Location:77 → 192

PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif

cd01213
Location:1575 → 1708

PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

pfam10409
Location:179 → 305

PTEN_C2; C2 domain of PTEN tumour-suppressor protein
NM_001387777.1 → NP_001374706.1 tensin-1 isoform 4

Status: REVIEWED

Source sequence(s)

AC009469, AC010136

Consensus CDS

CCDS92941.1

UniProtKB/Swiss-Prot

A0A804HI61, Q4ZG71, Q6IPI5, Q9HBL0

UniProtKB/TrEMBL

A0A494C067

Related

ENSP00000506917.1, ENST00000682258.1

Conserved Domains (6) summary

cd09927
Location:1563 → 1678

SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins

PHA03247
Location:897 → 1408

PHA03247; large tegument protein UL36; Provisional

cd01213
Location:1700 → 1833

PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

cd14560
Location:139 → 297

PTP_tensin-1; protein tyrosine phosphatase-like domain of tensin-1

pfam10409
Location:304 → 430

PTEN_C2; C2 domain of PTEN tumor-suppressor protein

cd20888
Location:16 → 72

C1_TNS1_v; protein kinase C conserved region 1 (C1 domain) found in tensin-1 (TNS1) variant and similar proteins
NM_022648.7 → NP_072174.3 tensin-1 isoform 1

See identical proteins and their annotated locations for NP_072174.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AB209238, AC009469, AF225896, AL706926, BC051304, BC126910, BQ045472

Consensus CDS

CCDS2407.1

UniProtKB/TrEMBL

B2RU35

Related

ENSP00000171887.4, ENST00000171887.8

Conserved Domains (5) summary

cd09927
Location:1459 → 1574

SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins

smart00012
Location:77 → 192

PTPc_DSPc; Protein tyrosine phosphatase, catalytic domain, undefined specificity

cd01213
Location:1596 → 1729

PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

pfam10409
Location:179 → 305

PTEN_C2; C2 domain of PTEN tumor-suppressor protein

cl26464
Location:555 → 944

Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

217799791..218033982 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047445637.1 → XP_047301593.1 tensin-1 isoform X2
XM_047445644.1 → XP_047301600.1 tensin-1 isoform X12

UniProtKB/TrEMBL

A0A2R8Y4T1

Related

ENSP00000493967.1, ENST00000646520.1
XM_047445639.1 → XP_047301595.1 tensin-1 isoform X6
XM_047445638.1 → XP_047301594.1 tensin-1 isoform X3
XM_047445636.1 → XP_047301592.1 tensin-1 isoform X1
XM_047445645.1 → XP_047301601.1 tensin-1 isoform X13
XM_047445642.1 → XP_047301598.1 tensin-1 isoform X10
XM_047445640.1 → XP_047301596.1 tensin-1 isoform X8
XM_024453079.2 → XP_024308847.1 tensin-1 isoform X5

UniProtKB/TrEMBL

A0A494C067

Conserved Domains (5) summary

cd09927
Location:1729 → 1844

SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins

PHA03247
Location:752 → 1167

PHA03247; large tegument protein UL36; Provisional

cd01213
Location:1866 → 1999

PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

cd14560
Location:139 → 297

PTP_tensin-1; protein tyrosine phosphatase-like domain of tensin-1

cl00040
Location:34 → 67

C1; protein kinase C conserved region 1 (C1 domain) superfamily
XM_047445641.1 → XP_047301597.1 tensin-1 isoform X9
XM_024453078.2 → XP_024308846.2 tensin-1 isoform X4
XM_024453084.2 → XP_024308852.1 tensin-1 isoform X22

UniProtKB/TrEMBL

B2RU35

Conserved Domains (5) summary

cd09927
Location:1459 → 1574

SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins

smart00012
Location:77 → 192

PTPc_DSPc; Protein tyrosine phosphatase, catalytic domain, undefined specificity

cd01213
Location:1596 → 1729

PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

pfam10409
Location:179 → 305

PTEN_C2; C2 domain of PTEN tumor-suppressor protein

cl26464
Location:555 → 944

Atrophin-1; Atrophin-1 family
XM_047445646.1 → XP_047301602.1 tensin-1 isoform X14
XM_024453081.2 → XP_024308849.1 tensin-1 isoform X11

UniProtKB/TrEMBL

A0A994J515

Conserved Domains (5) summary

cd09927
Location:1604 → 1719

SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins

smart00012
Location:77 → 192

PTPc_DSPc; Protein tyrosine phosphatase, catalytic domain, undefined specificity

cd01213
Location:1741 → 1874

PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

pfam10409
Location:179 → 305

PTEN_C2; C2 domain of PTEN tumor-suppressor protein

cl26464
Location:627 → 1042

Atrophin-1; Atrophin-1 family
XM_047445647.1 → XP_047301603.1 tensin-1 isoform X15
XM_024453080.2 → XP_024308848.1 tensin-1 isoform X7

UniProtKB/TrEMBL

A0A994J515

Conserved Domains (5) summary

cd09927
Location:1669 → 1784

SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins

smart00404
Location:142 → 257

PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif

cd01213
Location:1806 → 1939

PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

pfam10409
Location:244 → 370

PTEN_C2; C2 domain of PTEN tumor-suppressor protein

cl26464
Location:692 → 1107

Atrophin-1; Atrophin-1 family
XM_047445643.1 → XP_047301599.1 tensin-1 isoform X11
XM_047445650.1 → XP_047301606.1 tensin-1 isoform X20
XM_047445648.1 → XP_047301604.1 tensin-1 isoform X18
XM_047445649.1 → XP_047301605.1 tensin-1 isoform X19
XM_017004814.2 → XP_016860303.1 tensin-1 isoform X17
XM_047445651.1 → XP_047301607.1 tensin-1 isoform X21
XM_017004815.2 → XP_016860304.1 tensin-1 isoform X17
XM_017004813.3 → XP_016860302.1 tensin-1 isoform X16

UniProtKB/TrEMBL

A0A994J515

Alternate T2T-CHM13v2.0

Genomic

NC_060926.1 Alternate T2T-CHM13v2.0

Range

218283109..218495456 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054343623.1 → XP_054199598.1 tensin-1 isoform X12

UniProtKB/TrEMBL

A0A2R8Y4T1
XM_054343616.1 → XP_054199591.1 tensin-1 isoform X6
XM_054343611.1 → XP_054199586.1 tensin-1 isoform X3
XM_054343624.1 → XP_054199599.1 tensin-1 isoform X13
XM_054343620.1 → XP_054199595.1 tensin-1 isoform X10
XM_054343618.1 → XP_054199593.1 tensin-1 isoform X8
XM_054343614.1 → XP_054199589.1 tensin-1 isoform X5
XM_054343607.1 → XP_054199582.1 tensin-1 isoform X31
XM_054343619.1 → XP_054199594.1 tensin-1 isoform X9
XM_054343613.1 → XP_054199588.1 tensin-1 isoform X4
XM_054343638.1 → XP_054199613.1 tensin-1 isoform X22
XM_054343625.1 → XP_054199600.1 tensin-1 isoform X37
XM_054343615.1 → XP_054199590.1 tensin-1 isoform X36

UniProtKB/TrEMBL

E9PF55
XM_054343621.1 → XP_054199596.1 tensin-1 isoform X11
XM_054343626.1 → XP_054199601.1 tensin-1 isoform X15
XM_054343617.1 → XP_054199592.1 tensin-1 isoform X7
XM_054343612.1 → XP_054199587.1 tensin-1 isoform X35
XM_054343603.1 → XP_054199578.1 tensin-1 isoform X27
XM_054343610.1 → XP_054199585.1 tensin-1 isoform X34
XM_054343609.1 → XP_054199584.1 tensin-1 isoform X33
XM_054343608.1 → XP_054199583.1 tensin-1 isoform X32
XM_054343600.1 → XP_054199575.1 tensin-1 isoform X24
XM_054343606.1 → XP_054199581.1 tensin-1 isoform X30
XM_054343605.1 → XP_054199580.1 tensin-1 isoform X29
XM_054343602.1 → XP_054199577.1 tensin-1 isoform X26
XM_054343604.1 → XP_054199579.1 tensin-1 isoform X28
XM_054343601.1 → XP_054199576.1 tensin-1 isoform X25
XM_054343599.1 → XP_054199574.1 tensin-1 isoform X23
XM_054343622.1 → XP_054199597.1 tensin-1 isoform X11
XM_054343628.1 → XP_054199603.1 tensin-1 isoform X17
XM_054343631.1 → XP_054199606.1 tensin-1 isoform X19
XM_054343630.1 → XP_054199605.1 tensin-1 isoform X18
XM_054343632.1 → XP_054199607.1 tensin-1 isoform X20
XM_054343629.1 → XP_054199604.1 tensin-1 isoform X17
XM_054343634.1 → XP_054199609.1 tensin-1 isoform X38
XM_054343633.1 → XP_054199608.1 tensin-1 isoform X21
XM_054343627.1 → XP_054199602.1 tensin-1 isoform X16
XM_054343636.1 → XP_054199611.1 tensin-1 isoform X40
XM_054343635.1 → XP_054199610.1 tensin-1 isoform X39
XM_054343637.1 → XP_054199612.1 tensin-1 isoform X41

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_018274.2: Suppressed sequence

Description

NM_018274.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.