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    GBP4 guanylate binding protein 4 [ Homo sapiens (human) ]

    Gene ID: 115361, updated on 2-Nov-2024

    Summary

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    Official Symbol
    GBP4provided by HGNC
    Official Full Name
    guanylate binding protein 4provided by HGNC
    Primary source
    HGNC:HGNC:20480
    See related
    Ensembl:ENSG00000162654 MIM:612466; AllianceGenome:HGNC:20480
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Mpa2
    Summary
    Guanylate-binding proteins, such as GBP4, are induced by interferon and hydrolyze GTP to both GDP and GMP (Vestal, 2005 [PubMed 16108726]).[supplied by OMIM, Dec 2008]
    Expression
    Broad expression in lung (RPKM 16.3), lymph node (RPKM 13.8) and 23 other tissues See more
    Orthologs
    all
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    Genomic context

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    See GBP4 in Genome Data Viewer
    Location:
    1p22.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (89181144..89198942, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (89024523..89042320, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (89646827..89664625, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112268267 Neighboring gene Sharpr-MPRA regulatory region 4932 Neighboring gene guanylate binding protein 2 Neighboring gene uncharacterized LOC105378842 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:89614414-89615613 Neighboring gene guanylate binding protein 7 Neighboring gene uncharacterized LOC107985076 Neighboring gene Sharpr-MPRA regulatory region 13956 Neighboring gene guanylate binding protein family member 6 pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr1:89725724-89726225 Neighboring gene guanylate binding protein 5 Neighboring gene intraflagellar transport associated protein pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Guanylate binding protein 4 shapes an inflamed tumor microenvironment and identifies immuno-hot tumors. Zhou W, et al. J Cancer Res Clin Oncol, 2024 Feb 12. PMID 38347243, Free PMC Article
    2. The guanylate-binding proteins (GBPs): proinflammatory cytokine-induced members of the dynamin superfamily with unique GTPase activity. Vestal DJ. J Interferon Cytokine Res, 2005 Aug. PMID 16108726
    3. Cloning, expression, and characterization of a novel guanylate-binding protein, GBP3 in murine erythroid progenitor cells. Han BH, et al. Biochim Biophys Acta, 1998 May 19. PMID 9659399
    4. Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner. Britzen-Laurent N, et al. PLoS One, 2010 Dec 7. PMID 21151871, Free PMC Article
    5. Unique features of different members of the human guanylate-binding protein family. Tripal P, et al. J Interferon Cytokine Res, 2007 Jan. PMID 17266443

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Guanylate binding protein 4 shapes an inflamed tumor microenvironment and identifies immuno-hot tumors.
      Title: Guanylate binding protein 4 shapes an inflamed tumor microenvironment and identifies immuno-hot tumors.
    2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: New genetic associations detected in a host response study to hepatitis B vaccine.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120-treated vaginal epithelial cells show upregulation of guanylate binding protein 4 (GBP4) expression as compared to untreated control PubMed
    Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of guanylate binding protein 4 (GBP4) in primary human brain microvascular endothelial cells PubMed
    Vif vif HIV-1 Vif upregulates the expression of guanylate binding protein 4 (GBP4) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: GBP5

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to type II interferon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to type II interferon IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to protozoan IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    guanylate-binding protein 4
    Names
    GBP-4
    GTP-binding protein 4
    guanine nucleotide-binding protein 4
    NP_443173.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_052941.5 → NP_443173.2  guanylate-binding protein 4

      See identical proteins and their annotated locations for NP_443173.2

      Status: VALIDATED

      Source sequence(s)
      AC104459, AF288814, BC008421, BC070055, CA309701
      Consensus CDS
      CCDS721.1
      UniProtKB/Swiss-Prot
      B2R630, Q05D63, Q6NSL0, Q86T99, Q96PP9
      Related
      ENSP00000359490.5, ENST00000355754.7
      Conserved Domains (3) summary
      pfam02841
      Location:298 → 594
      GBP_C; Guanylate-binding protein, C-terminal domain
      pfam02263
      Location:33 → 296
      GBP; Guanylate-binding protein, N-terminal domain
      cd16269
      Location:304 → 594
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      89181144..89198942 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      89024523..89042320 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96PP9.2 GenPept UniProtKB/Swiss-Prot:Q96PP9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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