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    TRAM2 translocation associated membrane protein 2 [ Homo sapiens (human) ]

    Gene ID: 9697, updated on 2-May-2024

    Summary

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    Official Symbol
    TRAM2provided by HGNC
    Official Full Name
    translocation associated membrane protein 2provided by HGNC
    Primary source
    HGNC:HGNC:16855
    See related
    Ensembl:ENSG00000065308 MIM:608485; AllianceGenome:HGNC:16855
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    TRAM2 is a component of the translocon, a gated macromolecular channel that controls the posttranslational processing of nascent secretory and membrane proteins at the endoplasmic reticulum (ER) membrane.[supplied by OMIM, Jul 2004]
    Expression
    Broad expression in placenta (RPKM 12.1), testis (RPKM 6.9) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    6p12.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (52497408..52577060, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (52336220..52415808, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (52362206..52441858, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17283 Neighboring gene progestin and adipoQ receptor family member 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24676 Neighboring gene VISTA enhancer hs2064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24678 Neighboring gene Sharpr-MPRA regulatory region 10279 Neighboring gene uncharacterized LOC124901331 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:52285109-52285700 Neighboring gene EF-hand domain containing 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:52362612-52362813 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24679 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:52368564-52369763 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24680 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:52389524-52390029 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:52390030-52390534 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24681 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24682 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24683 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24684 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24685 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_92132 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:52438134-52438662 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24686 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17284 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17285 Neighboring gene TRAM2 antisense RNA 1 (head to head) Neighboring gene FOXA motif-containing MPRA enhancer 62 Neighboring gene uncharacterized LOC124901330

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A comprehensive enhancer screen identifies TRAM2 as a key and novel mediator of YAP oncogenesis. Li L, et al. Genome Biol, 2021 Jan 29. PMID 33514403, Free PMC Article
    2. Genomic organization of the KIAA0057 gene that encodes a TRAM-like protein and its exclusion as a polycystic kidney and hepatic disease 1 (PKHD1) candidate gene. Onuchic LF, et al. Mamm Genome, 1999 Dec. PMID 10594243
    3. Identification of TRAMs as sphingolipid-binding proteins using a photoactivatable and clickable short-chain ceramide analog. Deng Y, et al. J Biol Chem, 2021 Dec. PMID 34793833, Free PMC Article
    4. TRAM2 promotes the malignant progression of glioma through PI3K/AKT/mTOR pathway. Gao X, et al. Biochem Biophys Res Commun, 2022 Jan 1. PMID 34826698
    5. DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response. Zhong L, et al. J Biol Chem, 2015 Jun 19. PMID 25957402, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of TRAMs as sphingolipid-binding proteins using a photoactivatable and clickable short-chain ceramide analog.
      Title: Identification of TRAMs as sphingolipid-binding proteins using a photoactivatable and clickable short-chain ceramide analog.
    2. TRAM2 promotes the malignant progression of glioma through PI3K/AKT/mTOR pathway.
      Title: TRAM2 promotes the malignant progression of glioma through PI3K/AKT/mTOR pathway.
    3. A comprehensive enhancer screen identifies TRAM2 as a key and novel mediator of YAP oncogenesis.
      Title: A comprehensive enhancer screen identifies TRAM2 as a key and novel mediator of YAP oncogenesis.
    4. results support a role of DAP12 in stabilizing TREM2-CTF, thereby protecting against excessive pro-inflammatory responses.
      Title: DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response.
    5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    6. Observational study of gene-disease association. (HuGE Navigator)
      Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
    7. TRAM2, as a part of the translocon, is required for the biosynthesis of type I collagen by coupling the activity of SERCA2b with the activity of the translocon
      Title: TRAM2 protein interacts with endoplasmic reticulum Ca2+ pump Serca2b and is necessary for collagen type I synthesis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0057

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in collagen biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein insertion into ER membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein insertion into ER membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    translocating chain-associated membrane protein 2
    Names
    TRAM-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012288.4 → NP_036420.1  translocating chain-associated membrane protein 2

      See identical proteins and their annotated locations for NP_036420.1

      Status: REVIEWED

      Source sequence(s)
      AL049611, BC028121, D31762
      Consensus CDS
      CCDS34477.1
      UniProtKB/Swiss-Prot
      A8K6T6, Q15035
      UniProtKB/TrEMBL
      A0A024RD84
      Related
      ENSP00000182527.3, ENST00000182527.4
      Conserved Domains (2) summary
      smart00724
      Location:112 → 321
      TLC; TRAM, LAG1 and CLN8 homology domains
      pfam08390
      Location:49 → 110
      TRAM1; TRAM1-like protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      52497408..52577060 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011515005.3 → XP_011513307.1  translocating chain-associated membrane protein 2 isoform X1

      Conserved Domains (2) summary
      smart00724
      Location:75 → 284
      TLC; TRAM, LAG1 and CLN8 homology domains
      pfam08390
      Location:25 → 73
      TRAM1; TRAM1-like protein

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      52336220..52415808 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356881.1 → XP_054212856.1  translocating chain-associated membrane protein 2 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15035.1 GenPept UniProtKB/Swiss-Prot:Q15035

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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