VASP vasodilator stimulated phosphoprotein [Homo sapiens (human)] - Gene

Summary

Official Symbol: VASPprovided by HGNC
Official Full Name: vasodilator stimulated phosphoproteinprovided by HGNC
Primary source: HGNC:HGNC:12652
See related: Ensembl:ENSG00000125753 MIM:601703; AllianceGenome:HGNC:12652
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in appendix (RPKM 50.6), spleen (RPKM 48.4) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.32

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (45507479..45526983)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (48334741..48354257)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (46010737..46030241)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PKCzeta phosphorylates VASP to mediate chemotaxis in breast cancer cells.
Title: PKCζ phosphorylates VASP to mediate chemotaxis in breast cancer cells.
Expression of the phagocytic receptors alphaMbeta2 and alphaXbeta2 is controlled by RIAM, VASP and Vinculin in neutrophil-differentiated HL-60 cells.
Title: Expression of the phagocytic receptors α(M)β(2) and α(X)β(2) is controlled by RIAM, VASP and Vinculin in neutrophil-differentiated HL-60 cells.
Arp2/3 and Mena/VASP Require Profilin 1 for Actin Network Assembly at the Leading Edge.
Title: Arp2/3 and Mena/VASP Require Profilin 1 for Actin Network Assembly at the Leading Edge.
Up-regulation of SNHG15 facilitates cell proliferation, migration, invasion and suppresses cell apoptosis in breast cancer by regulating miR-411-5p/VASP axis.
Title: Up-regulation of SNHG15 facilitates cell proliferation, migration, invasion and suppresses cell apoptosis in breast cancer by regulating miR-411-5p/VASP axis.
RIAM-VASP Module Relays Integrin Complement Receptors in Outside-In Signaling Driving Particle Engulfment.
Title: RIAM-VASP Module Relays Integrin Complement Receptors in Outside-In Signaling Driving Particle Engulfment.
Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.
Title: Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.
Depletion of LAMP3 enhances PKA-mediated VASP phosphorylation to suppress invasion and metastasis in esophageal squamous cell carcinoma.
Title: Depletion of LAMP3 enhances PKA-mediated VASP phosphorylation to suppress invasion and metastasis in esophageal squamous cell carcinoma.
Transfer of HTLV-1 p8 and Gag to target T-cells depends on VASP, a novel interaction partner of p8.
Title: Transfer of HTLV-1 p8 and Gag to target T-cells depends on VASP, a novel interaction partner of p8.
ANGPTL3 inhibits renal cell carcinoma metastasis by inhibiting VASP phosphorylation.
Title: ANGPTL3 inhibits renal cell carcinoma metastasis by inhibiting VASP phosphorylation.
this study highlights the important roles of BLACAT1/miR-605-3p/VASP axis in glioma progression.
Title: LncRNA BLACAT1 regulates VASP expression via binding to miR-605-3p and promotes giloma development.

Submit: New GeneRIF Correction See all GeneRIFs (109)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235612

D19S1038 (e-PCR)
- UniSTS:75460

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables cadherin binding	HDA more info	PubMed
enables profilin binding	IBA Inferred from Biological aspect of Ancestor more info
enables profilin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin polymerization or depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in neural tube closure	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of actin filament polymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein homotetramerization	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	TAS Traceable Author Statement more info	PubMed
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in filopodium membrane	IEA Inferred from Electronic Annotation more info
located_in focal adhesion	HDA more info	PubMed
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IDA Inferred from Direct Assay more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in lamellipodium membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: vasodilator-stimulated phosphoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003370.4 → NP_003361.1 vasodilator-stimulated phosphoprotein

See identical proteins and their annotated locations for NP_003361.1

Status: REVIEWED

Source sequence(s)

BC038224, BG751094, Z46389

Consensus CDS

CCDS33051.1

UniProtKB/Swiss-Prot

B2RBT9, P50552, Q6PIZ1, Q93035

UniProtKB/TrEMBL

A0A024R0V4, A0A0S2Z4I9

Related

ENSP00000245932.5, ENST00000245932.11

Conserved Domains (2) summary

cd01207
Location:5 → 113

EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain

pfam08776
Location:342 → 376

VASP_tetra; VASP tetramerization domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

45507479..45526983

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005259200.3 → XP_005259257.1 vasodilator-stimulated phosphoprotein isoform X2

UniProtKB/TrEMBL

A0A0S2Z4I9

Conserved Domains (2) summary

cd01207
Location:5 → 113

EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain

pfam08776
Location:341 → 375

VASP_tetra; VASP tetramerization domain
XM_005259199.3 → XP_005259256.1 vasodilator-stimulated phosphoprotein isoform X1

See identical proteins and their annotated locations for XP_005259256.1

UniProtKB/TrEMBL

A0A0S2Z4I9

Related

ENSP00000516196.1, ENST00000705986.1

Conserved Domains (2) summary

cd01207
Location:5 → 113

EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain

pfam08776
Location:341 → 375

VASP_tetra; VASP tetramerization domain
XM_017027200.3 → XP_016882689.1 vasodilator-stimulated phosphoprotein isoform X3

UniProtKB/TrEMBL

A0A0S2Z4I9

Alternate T2T-CHM13v2.0

Genomic

NC_060943.1 Alternate T2T-CHM13v2.0

Range

48334741..48354257

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054321942.1 → XP_054177917.1 vasodilator-stimulated phosphoprotein isoform X2
XM_054321941.1 → XP_054177916.1 vasodilator-stimulated phosphoprotein isoform X1
XM_054321943.1 → XP_054177918.1 vasodilator-stimulated phosphoprotein isoform X3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001008736.1: Suppressed sequence

Description

NM_001008736.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.