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    Gp1bb glycoprotein Ib platelet subunit beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116727, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Gp1bbprovided by RGD
    Official Full Name
    glycoprotein Ib platelet subunit betaprovided by RGD
    Primary source
    RGD:621050
    See related
    AllianceGenome:RGD:621050
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including blood coagulation, intrinsic pathway; megakaryocyte development; and positive regulation of platelet activation. Predicted to be part of glycoprotein Ib-IX-V complex. Human ortholog(s) of this gene implicated in Bernard-Soulier syndrome. Orthologous to human GP1BB (glycoprotein Ib platelet subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 69.0), Brain (RPKM 61.9) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gp1bb in Genome Data Viewer
    Location:
    11q23
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (95882561..95883738)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (82378216..82379393)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (86520992..86522169)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480932 Neighboring gene uncharacterized LOC120095702 Neighboring gene uncharacterized LOC134481101 Neighboring gene septin 5 Neighboring gene T-box transcription factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Bernard-soulier syndrome with a homozygous 13 base pair deletion in the signal peptide-coding region of the platelet glycoprotein Ib(beta) gene. Watanabe R, et al. Blood Coagul Fibrinolysis, 2003 Jun. PMID 12945881
    2. Patients with Bernard-Soulier syndrome and different severity of the bleeding phenotype. Boeckelmann D, et al. Blood Cells Mol Dis, 2017 Sep. PMID 28131619
    3. Reciprocal expression of infant- and adult-preferring transcripts of CDCrel-1 septin gene in the rat neocortex. Toda S, et al. Biochem Biophys Res Commun, 2000 Jul 5. PMID 10873671
    4. Missense mutations of the glycoprotein (GP) Ib beta gene impairing the GPIb alpha/beta disulfide linkage in a family with giant platelet disorder. Kunishima S, et al. Blood, 1997 Apr 1. PMID 9116284
    5. Decreased thrombotic tendency in mouse models of the Bernard-Soulier syndrome. Strassel C, et al. Arterioscler Thromb Vasc Biol, 2007 Jan. PMID 17095718

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in blood coagulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in blood coagulation, intrinsic pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in megakaryocyte development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of platelet activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of glycoprotein Ib-IX-V complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    platelet glycoprotein Ib beta chain
    Names
    GP-Ib beta
    GPIb-beta
    GPIbB
    glycoprotein Ib (platelet), beta polypeptide
    glycoprotein Ib platelet beta subunit
    glycoprotein Ib, beta polypeptide

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053930.4 → NP_446382.1  platelet glycoprotein Ib beta chain precursor

      See identical proteins and their annotated locations for NP_446382.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/Swiss-Prot
      Q9JJM7
      Conserved Domains (3) summary
      smart00013
      Location:25 → 59
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:89 → 135
      LRRCT; Leucine rich repeat C-terminal domain
      sd00031
      Location:58 → 80
      LRR_1; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      95882561..95883738
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JJM7.1 GenPept UniProtKB/Swiss-Prot:Q9JJM7

    Gene LinkOut

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