Rapgef1 Rap guanine nucleotide exchange factor (GEF) 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rapgef1provided by MGI
Official Full Name: Rap guanine nucleotide exchange factor (GEF) 1provided by MGI
Primary source: MGI:MGI:104580
See related: Ensembl:ENSMUSG00000039844 AllianceGenome:MGI:104580
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C3G; Grf2; 4932418O06Rik
Summary: Enables guanyl-nucleotide exchange factor activity. Acts upstream of or within several processes, including activation of GTPase activity; negative regulation of signal transduction; and platelet-derived growth factor receptor signaling pathway. Predicted to be located in early endosome; perinuclear region of cytoplasm; and phagocytic vesicle membrane. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human RAPGEF1 (Rap guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 38.9), spleen adult (RPKM 34.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 B; 2 20.32 cM

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (29509732..29630376)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (29619720..29740364)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C3G Regulates STAT3, ERK, Adhesion Signaling, and Is Essential for Differentiation of Embryonic Stem Cells.
Title: C3G Regulates STAT3, ERK, Adhesion Signaling, and Is Essential for Differentiation of Embryonic Stem Cells.
Adapter Protein RapGEF1 Is Required for ERK1/2 Signaling in Response to Elevated Phosphate in Vascular Smooth Muscle Cells.
Title: Adapter Protein RapGEF1 Is Required for ERK1/2 Signaling in Response to Elevated Phosphate in Vascular Smooth Muscle Cells.
C3G contributes to platelet activation and aggregation by regulating major signaling pathways.
Title: C3G contributes to platelet activation and aggregation by regulating major signaling pathways.
C3G localizes to the mother centriole in a cenexin-dependent manner and regulates centrosome duplication and primary cilium length.
Title: C3G localizes to the mother centriole in a cenexin-dependent manner and regulates centrosome duplication and primary cilium length.
C3G is required in cortical neurons for both the specification of an axon and the initiation of radial migration by forming a leading process.
Title: C3G/Rapgef1 Is Required in Multipolar Neurons for the Transition to a Bipolar Morphology during Cortical Development.
results provide evidence that C3G plays an important role in myogenic differentiation by coordinating cell cycle exit, actin dynamics and survival signaling.
Title: C3G (RapGEF1), a regulator of actin dynamics promotes survival and myogenic differentiation of mouse mesenchymal cells.
C3G regulates sympathetic preganglionic neuron migration by acting downstream in the reelin signaling pathway.
Title: Migration of sympathetic preganglionic neurons in the spinal cord of a C3G-deficient mouse suggests that C3G acts in the reelin signaling pathway.
Data indicate that chemical rescue of c-Src provided a tool to dissect the spatiotemporal mechanism of activation of the Rap1 guanine exchange factor, C3G, one of the identified potential c-Src substrates that plays a role in focal adhesion signaling.
Title: Identification of targets of c-Src tyrosine kinase by chemical complementation and phosphoproteomics.
GEF and Dlx1/2 form part of a common signalling pathway during GABAergic neuronal development.
Title: Expression of the Rap1 guanine nucleotide exchange factor, MR-GEF, is altered in individuals with bipolar disorder.
Guanine nucleotide releasing factor 2 is a negative regulator of Mitogen-Activated Protein Kinase 14 in mouse embryonic fibroblasts and can promote cell survival or cell death depending on the stimuli.
Title: C3G down-regulates p38 MAPK activity in response to stress by Rap-1 independent mechanisms: involvement in cell death.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:224268 (e-PCR)
- UniSTS:224268

NoName (e-PCR)
- UniSTS:225096

Rapgef1 (e-PCR), detects polymorphism
- UniSTS:477295

Rapgef1 (e-PCR), detects polymorphism
- UniSTS:477296

UniSTS:234364 (e-PCR)
- UniSTS:234364

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IDA Inferred from Direct Assay more info	PubMed
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of ERK1 and ERK2 cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Rap protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of Ras protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within activation of GTPase activity	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nerve growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in establishment of endothelial barrier	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of Ras protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of neural precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nerve growth factor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of neural precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within platelet-derived growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Fc receptor mediated stimulatory signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of Fc receptor mediated stimulatory signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phagocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell junction assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in phagocytic vesicle membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rap guanine nucleotide exchange factor 1

Names: guanine nucleotide releasing factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039086.1 → NP_001034175.1 rap guanine nucleotide exchange factor 1 isoform 2

See identical proteins and their annotated locations for NP_001034175.1

Status: VALIDATED

Source sequence(s)

AK077034, AK147470, AK147696

Consensus CDS

CCDS38092.1

UniProtKB/TrEMBL

Q3UGX8

Related

ENSMUSP00000088680.6, ENSMUST00000091146.12

Conserved Domains (2) summary

smart00147
Location:977 → 1206

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:829 → 970

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
NM_001039087.2 → NP_001034176.1 rap guanine nucleotide exchange factor 1 isoform 1

See identical proteins and their annotated locations for NP_001034176.1

Status: VALIDATED

Source sequence(s)

AL845323

Consensus CDS

CCDS38091.1

UniProtKB/TrEMBL

Q3UHC1

Related

ENSMUSP00000092703.5, ENSMUST00000095087.11

Conserved Domains (2) summary

smart00147
Location:983 → 1212

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:835 → 976

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
NM_001362702.1 → NP_001349631.1 rap guanine nucleotide exchange factor 1 isoform 4

Status: VALIDATED

Source sequence(s)

AK077034, AK147468, BC129881

Consensus CDS

CCDS89458.1

UniProtKB/TrEMBL

A1L338, E0CXV1

Related

ENSMUSP00000121615.4, ENSMUST00000147755.10

Conserved Domains (4) summary

smart00147
Location:944 → 1173

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:796 → 937

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cl26464
Location:188 → 298

Atrophin-1; Atrophin-1 family

cl27601
Location:663 → 778

Pectinesterase; Pectinesterase
NM_054050.2 → NP_473391.1 rap guanine nucleotide exchange factor 1 isoform 3

See identical proteins and their annotated locations for NP_473391.1

Status: VALIDATED

Source sequence(s)

AF348669, AK077034, AK147470

Consensus CDS

CCDS15854.1

UniProtKB/TrEMBL

Q91ZZ2

Related

ENSMUSP00000099936.5, ENSMUST00000102872.11

Conserved Domains (2) summary

smart00147
Location:845 → 1074

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:697 → 838

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

29509732..29630376

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006497583.2 → XP_006497646.1 rap guanine nucleotide exchange factor 1 isoform X2

Conserved Domains (4) summary

smart00147
Location:1015 → 1244

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:867 → 1008

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

PHA03247
Location:226 → 336

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:677 → 877

PHA03307; transcriptional regulator ICP4; Provisional
XM_030246484.1 → XP_030102344.1 rap guanine nucleotide exchange factor 1 isoform X17

Conserved Domains (3) summary

smart00147
Location:897 → 1126

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:749 → 890

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

PHA03247
Location:226 → 336

PHA03247; large tegument protein UL36; Provisional
XM_036157277.1 → XP_036013170.1 rap guanine nucleotide exchange factor 1 isoform X4

Conserved Domains (4) summary

smart00147
Location:1014 → 1243

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:866 → 1007

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

PHA03247
Location:226 → 336

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:676 → 876

PHA03307; transcriptional regulator ICP4; Provisional
XM_036157284.1 → XP_036013177.1 rap guanine nucleotide exchange factor 1 isoform X8

Conserved Domains (4) summary

smart00147
Location:982 → 1211

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:834 → 975

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

PLN02217
Location:701 → 816

PLN02217; probable pectinesterase/pectinesterase inhibitor

PHA03247
Location:226 → 336

PHA03247; large tegument protein UL36; Provisional
XM_036157298.1 → XP_036013191.1 rap guanine nucleotide exchange factor 1 isoform X13

Conserved Domains (3) summary

smart00147
Location:945 → 1174

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:797 → 938

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

PHA03247
Location:191 → 751

PHA03247; large tegument protein UL36; Provisional
XM_030246482.1 → XP_030102342.1 rap guanine nucleotide exchange factor 1 isoform X11

Conserved Domains (4) summary

smart00147
Location:976 → 1205

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:828 → 969

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

PHA03247
Location:188 → 298

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:638 → 838

PHA03307; transcriptional regulator ICP4; Provisional
XM_030246487.1 → XP_030102347.1 rap guanine nucleotide exchange factor 1 isoform X22

Conserved Domains (3) summary

smart00147
Location:807 → 1036

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:659 → 800

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

PHA03247
Location:188 → 298

PHA03247; large tegument protein UL36; Provisional
XM_030246485.2 → XP_030102345.1 rap guanine nucleotide exchange factor 1 isoform X19

Conserved Domains (4) summary

smart00147
Location:886 → 1115

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:738 → 879

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

PHA03247
Location:97 → 207

PHA03247; large tegument protein UL36; Provisional

pfam05110
Location:566 → 704

AF-4; AF-4 proto-oncoprotein
XM_030246488.2 → XP_030102348.1 rap guanine nucleotide exchange factor 1 isoform X23

Conserved Domains (3) summary

smart00147
Location:768 → 997

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:620 → 761

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

PHA03247
Location:97 → 207

PHA03247; large tegument protein UL36; Provisional
XM_036157280.1 → XP_036013173.1 rap guanine nucleotide exchange factor 1 isoform X6

Conserved Domains (4) summary

smart00147
Location:984 → 1213

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:836 → 977

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

PHA03247
Location:195 → 305

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:646 → 846

PHA03307; transcriptional regulator ICP4; Provisional
XM_006497582.4 → XP_006497645.1 rap guanine nucleotide exchange factor 1 isoform X1

Conserved Domains (4) summary

smart00147
Location:1016 → 1245

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:868 → 1009

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

PHA03247
Location:227 → 337

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:678 → 878

PHA03307; transcriptional regulator ICP4; Provisional
XM_006497585.5 → XP_006497648.1 rap guanine nucleotide exchange factor 1 isoform X5

Conserved Domains (3) summary

smart00147
Location:984 → 1213

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:836 → 977

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

PHA03247
Location:230 → 790

PHA03247; large tegument protein UL36; Provisional
XM_006497589.4 → XP_006497652.1 rap guanine nucleotide exchange factor 1 isoform X16

Conserved Domains (3) summary

smart00147
Location:898 → 1127

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:750 → 891

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

PHA03247
Location:227 → 337

PHA03247; large tegument protein UL36; Provisional
XM_006497584.4 → XP_006497647.1 rap guanine nucleotide exchange factor 1 isoform X3

Conserved Domains (4) summary

smart00147
Location:1015 → 1244

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:867 → 1008

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

PHA03247
Location:227 → 337

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:677 → 877

PHA03307; transcriptional regulator ICP4; Provisional
XM_030246481.2 → XP_030102341.1 rap guanine nucleotide exchange factor 1 isoform X7

Conserved Domains (4) summary

smart00147
Location:983 → 1212

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:835 → 976

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

PLN02217
Location:702 → 817

PLN02217; probable pectinesterase/pectinesterase inhibitor

PHA03247
Location:227 → 337

PHA03247; large tegument protein UL36; Provisional
XM_006497590.4 → XP_006497653.1 rap guanine nucleotide exchange factor 1 isoform X18

Conserved Domains (3) summary

smart00147
Location:897 → 1126

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:749 → 890

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

PHA03247
Location:227 → 337

PHA03247; large tegument protein UL36; Provisional
XM_006497587.5 → XP_006497650.1 rap guanine nucleotide exchange factor 1 isoform X12

Conserved Domains (4) summary

smart00147
Location:964 → 1193

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:816 → 957

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

PHA03247
Location:227 → 337

PHA03247; large tegument protein UL36; Provisional

pfam05110
Location:644 → 782

AF-4; AF-4 proto-oncoprotein
XM_036157299.1 → XP_036013192.1 rap guanine nucleotide exchange factor 1 isoform X15

Conserved Domains (3) summary

smart00147
Location:932 → 1161

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:784 → 925

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

PHA03247
Location:228 → 738

PHA03247; large tegument protein UL36; Provisional
XM_006497592.4 → XP_006497655.1 rap guanine nucleotide exchange factor 1 isoform X20

UniProtKB/TrEMBL

A0A5F8MPI9

Related

ENSMUSP00000158995.2, ENSMUST00000238899.2

Conserved Domains (3) summary

smart00147
Location:846 → 1075

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:698 → 839

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

PHA03247
Location:227 → 337

PHA03247; large tegument protein UL36; Provisional
XM_006497586.5 → XP_006497649.1 rap guanine nucleotide exchange factor 1 isoform X9

Conserved Domains (4) summary

smart00147
Location:978 → 1207

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:830 → 971

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

PHA03247
Location:189 → 299

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:640 → 840

PHA03307; transcriptional regulator ICP4; Provisional
XM_036157288.1 → XP_036013181.1 rap guanine nucleotide exchange factor 1 isoform X10

Conserved Domains (4) summary

smart00147
Location:977 → 1206

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:829 → 970

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

PHA03247
Location:189 → 299

PHA03247; large tegument protein UL36; Provisional

PHA03307
Location:639 → 839

PHA03307; transcriptional regulator ICP4; Provisional
XM_030246483.2 → XP_030102343.1 rap guanine nucleotide exchange factor 1 isoform X14

Conserved Domains (4) summary

smart00147
Location:945 → 1174

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:797 → 938

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

PLN02217
Location:664 → 779

PLN02217; probable pectinesterase/pectinesterase inhibitor

PHA03247
Location:189 → 299

PHA03247; large tegument protein UL36; Provisional
XM_036157304.1 → XP_036013197.1 rap guanine nucleotide exchange factor 1 isoform X21

Conserved Domains (3) summary

smart00147
Location:808 → 1037

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:660 → 801

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

PHA03247
Location:189 → 299

PHA03247; large tegument protein UL36; Provisional