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    ZNF257 zinc finger protein 257 [ Homo sapiens (human) ]

    Gene ID: 113835, updated on 2-Nov-2024

    Summary

    Official Symbol
    ZNF257provided by HGNC
    Official Full Name
    zinc finger protein 257provided by HGNC
    Primary source
    HGNC:HGNC:13498
    See related
    Ensembl:ENSG00000197134 MIM:606957; AllianceGenome:HGNC:13498
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BMZF4; BMZF-4
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 1.5), lymph node (RPKM 1.1) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ZNF257 in Genome Data Viewer
    Location:
    19p12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (22052484..22091480)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (22190878..22229875)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (22235286..22274282)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 208 Neighboring gene uncharacterized LOC124904672 Neighboring gene BCL2 interacting protein 3 pseudogene 28 Neighboring gene uncharacterized LOC112268248 Neighboring gene BCL2 interacting protein 3 pseudogene 29 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:22322832-22323332 Neighboring gene zinc finger protein 92 pseudogene 2 Neighboring gene polycomb group ring finger 7 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    zinc finger protein 257
    Names
    bone marrow zinc finger 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001316996.2NP_001303925.1  zinc finger protein 257 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' end and begins translation from a downstream AUG compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AC011482, BC036446, DB001158
      UniProtKB/Swiss-Prot
      Q9Y2Q1
      Conserved Domains (4) summary
      smart00349
      Location:132
      KRAB; krueppel associated box
      COG5048
      Location:125442
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:286306
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:271295
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001316997.2NP_001303926.1  zinc finger protein 257 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate exon in the 3' end and begins translation from a downstream AUG compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
      Source sequence(s)
      AC011482, BC036446, BU155753, DB001158
      UniProtKB/Swiss-Prot
      Q9Y2Q1
      Conserved Domains (3) summary
      COG5048
      Location:81396
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:242262
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:227251
      zf-H2C2_2; Zinc-finger double domain
    3. NM_001316998.2NP_001303927.1  zinc finger protein 257 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate internal exons and begins translation from a downstream AUG compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
      Source sequence(s)
      AC011482, BC036446, DB134269
      UniProtKB/Swiss-Prot
      Q9Y2Q1
      Conserved Domains (3) summary
      COG5048
      Location:81396
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:242262
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:227251
      zf-H2C2_2; Zinc-finger double domain
    4. NM_033468.4NP_258429.2  zinc finger protein 257 isoform a

      See identical proteins and their annotated locations for NP_258429.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AC011482, BC036446, DB001158
      Consensus CDS
      CCDS46030.1
      UniProtKB/Swiss-Prot
      B3KPS4, E9PG34, Q8NE34, Q9Y2Q1
      Related
      ENSP00000470209.1, ENST00000594947.6
      Conserved Domains (5) summary
      smart00349
      Location:464
      KRAB; krueppel associated box
      COG5048
      Location:157474
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:318338
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:443
      KRAB; KRAB box
      pfam13465
      Location:303327
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      22052484..22091480
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047438121.1XP_047294077.1  zinc finger protein 257 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      22190878..22229875
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319696.1XP_054175671.1  zinc finger protein 257 isoform X1