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    Kng2 kininogen 2 [ Mus musculus (house mouse) ]

    Gene ID: 385643, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Kng2provided by MGI
    Official Full Name
    kininogen 2provided by MGI
    Primary source
    MGI:MGI:3027157
    See related
    Ensembl:ENSMUSG00000060459 AllianceGenome:MGI:3027157
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable cysteine-type endopeptidase inhibitor activity; hormone activity; and protease binding activity. Predicted to be involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; negative regulation of blood coagulation; and vasodilation. Predicted to be located in extracellular space and perikaryon. Predicted to be active in extracellular region. Human ortholog(s) of this gene implicated in hereditary angioedema and high molecular weight kininogen deficiency. Orthologous to human KNG1 (kininogen 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in liver E18 (RPKM 103.8), liver adult (RPKM 51.3) and 4 other tissues See more
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    Genomic context

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    See Kng2 in Genome Data Viewer
    Location:
    16 B1; 16 13.82 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (22804602..22847851, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (22985852..23029101, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene fetuin beta Neighboring gene STARR-seq mESC enhancer starr_40421 Neighboring gene STARR-seq mESC enhancer starr_40422 Neighboring gene histidine-rich glycoprotein Neighboring gene STARR-seq mESC enhancer starr_40423 Neighboring gene STARR-seq mESC enhancer starr_40424 Neighboring gene transportin 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40425 Neighboring gene tryptophan rich basic protein pseudogene Neighboring gene ribosomal protein S3 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A second expressed kininogen gene in mice. Shesely EG, et al. Physiol Genomics, 2006 Jul 12. PMID 16837654
    2. Structure and expression of two kininogen genes in mice. Cardoso CC, et al. Biol Chem, 2004 Mar-Apr. PMID 15134344
    3. Kininogen supports inflammation and bacterial spreading during Streptococccus Pyogenes Sepsis. Köhler J, et al. EBioMedicine, 2020 Aug. PMID 32707450, Free PMC Article
    4. Molecular characterization of mutant mouse strains generated from the EUCOMM/KOMP-CSD ES cell resource. Ryder E, et al. Mamm Genome, 2013 Aug. PMID 23912999, Free PMC Article
    5. Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Naba A, et al. Sci Rep, 2017 Jan 10. PMID 28071719, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC117836, MGC123404

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hormone activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in killing of cells of another organism ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of blood coagulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of blood coagulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vasodilation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kininogen 2
    Names
    Kininogen-II
    kininogen II

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001102409.1 → NP_001095879.1  kininogen 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001095879.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice pattern in the 3' coding region, compared to variant 1. The resulting isoform (2), also known as LMW kininogen-II, has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AA086752, BC139720, BY773346, CT027991
      Consensus CDS
      CCDS49801.1
      UniProtKB/TrEMBL
      Q6S9I0
      Related
      ENSMUSP00000111006.3, ENSMUST00000115349.9
      Conserved Domains (1) summary
      smart00043
      Location:263 → 370
      CY; Cystatin-like domain

    2. NM_001102410.1 → NP_001095880.1  kininogen 2 isoform 3 precursor

      See identical proteins and their annotated locations for NP_001095880.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice pattern in the 3' coding region, compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AA403606, BC139720, BY773346
      Consensus CDS
      CCDS49802.1
      UniProtKB/TrEMBL
      Q6S9I2
      Related
      ENSMUSP00000046867.7, ENSMUST00000039338.13
      Conserved Domains (1) summary
      smart00043
      Location:263 → 370
      CY; Cystatin-like domain

    3. NM_201375.2 → NP_958763.1  kininogen 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_958763.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1), also known as HMW kininogen-II.
      Source sequence(s)
      AA403606, BC139720, BY773346, CT027991
      Consensus CDS
      CCDS28072.1
      UniProtKB/TrEMBL
      Q6DMP4, Q6S9I3
      Related
      ENSMUSP00000097623.3, ENSMUST00000100046.9
      Conserved Domains (1) summary
      smart00043
      Location:263 → 370
      CY; Cystatin-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      22804602..22847851 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522324.1 → XP_006522387.1  kininogen 2 isoform X1

      Conserved Domains (1) summary
      smart00043
      Location:179 → 286
      CY; Cystatin-like domain
    Nucleotide Protein Strain
    Heading Accession and Version

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