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    LOC102723996 ICOS ligand [ Homo sapiens (human) ]

    Gene ID: 102723996, updated on 17-Jun-2024

    Summary

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    Gene symbol
    LOC102723996
    Gene description
    ICOS ligand
    See related
    Ensembl:ENSG00000277117
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Annotation information
    Note: GeneID:102723996 is on a scaffold that is thought to be a false duplication and thus this gene is likely redundant with GeneID:23308. [10 Jun 2021]
    Expression
    Ubiquitous expression in brain (RPKM 4.3), lymph node (RPKM 3.5) and 23 other tissues See more
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    Genomic context

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    See LOC102723996 in Genome Data Viewer
    Location:
    21p12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (5022531..5046683)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379484 Neighboring gene DNA (cytosine-5)-methyltransferase 3-like Neighboring gene uncharacterized LOC124905052 Neighboring gene uncharacterized LOC124900468 Neighboring gene putative proline-rich protein 21 Neighboring gene uncharacterized CH507-9B2.8

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000021.9 Chromosome 21 Reference GRCh38.p14 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See studies and variants in dbVar

    Genotypes

    General protein information

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    Preferred Names
    ICOS ligand

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363770.2 → NP_001350699.1  ICOS ligand precursor

      Status: VALIDATED

      Source sequence(s)
      FP565260
      UniProtKB/Swiss-Prot
      A8MUZ1, O75144, Q9HD18, Q9NRQ1
      UniProtKB/TrEMBL
      A0A8V8TQ42, A0N0L8
      Related
      ENST00000623960.4
      Conserved Domains (2) summary
      pfam07686
      Location:20 → 131
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:153 → 212
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      5022531..5046683
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047440643.1 → XP_047296599.1  ICOS ligand isoform X5

    2. XM_011546078.3 → XP_011544380.1  ICOS ligand isoform X2

      See identical proteins and their annotated locations for XP_011544380.1

      UniProtKB/TrEMBL
      A0A2R8Y5W7
      Conserved Domains (2) summary
      pfam07686
      Location:20 → 131
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:153 → 225
      Ig; Immunoglobulin domain

    3. XM_047440644.1 → XP_047296600.1  ICOS ligand isoform X5

    4. XM_047440646.1 → XP_047296602.1  ICOS ligand isoform X7

      UniProtKB/TrEMBL
      A0A8V8TQ42

    5. XM_006723899.3 → XP_006723962.1  ICOS ligand isoform X1

      UniProtKB/TrEMBL
      K4DIA0
      Conserved Domains (2) summary
      pfam07686
      Location:20 → 131
      V-set; Immunoglobulin V-set domain
      cl11960
      Location:153 → 225
      Ig; Immunoglobulin domain

    6. XM_011546079.2 → XP_011544381.1  ICOS ligand isoform X3

      See identical proteins and their annotated locations for XP_011544381.1

      UniProtKB/TrEMBL
      A0A8V8TQ42, A0A8V8TQV9
      Conserved Domains (3) summary
      cd00096
      Location:154 → 162
      Ig; Ig strand B [structural motif]
      cd20935
      Location:23 → 135
      IgV_B7-H2; Immunoglobulin Variable (IgV) domain of B7-H2 (B7 homolog 2)
      cl11960
      Location:149 → 224
      Ig; Immunoglobulin domain

    7. XM_047440645.1 → XP_047296601.1  ICOS ligand isoform X6

    8. XM_047440647.1 → XP_047296603.1  ICOS ligand isoform X8

      UniProtKB/TrEMBL
      A0A8V8TQ42

    9. XM_047440648.1 → XP_047296604.1  ICOS ligand isoform X8

      UniProtKB/TrEMBL
      A0A8V8TQ42

    10. XM_047440642.1 → XP_047296598.1  ICOS ligand isoform X4

    Nucleotide Protein
    Heading Accession and Version

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