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    Xlr3a X-linked lymphocyte-regulated 3A [ Mus musculus (house mouse) ]

    Gene ID: 22445, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Xlr3aprovided by MGI
    Official Full Name
    X-linked lymphocyte-regulated 3Aprovided by MGI
    Primary source
    MGI:MGI:109506
    See related
    Ensembl:ENSMUSG00000057836 AllianceGenome:MGI:109506
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Xlr3
    Summary
    Predicted to be involved in meiotic cell cycle and spermatid development. Predicted to be active in synaptonemal complex. Is expressed in several structures, including blood; central nervous system; female reproductive system; sensory organ; and submandibular gland primordium. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in placenta adult (RPKM 19.3), liver E18 (RPKM 4.2) and 6 other tissues See more
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    Genomic context

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    See Xlr3a in Genome Data Viewer
    Location:
    X A7.3; X 37.29 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (72129899..72140701, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (73086293..73097095, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene paraneoplastic antigen MA3 Neighboring gene X-linked lymphocyte-regulated 4A Neighboring gene X-linked lymphocyte-regulated 5A Neighboring gene PWWP domain containing 4A Neighboring gene PWWP domain containing 4B Neighboring gene X-linked lymphocyte-regulated 5B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sequence and expression of murine cDNAs encoding Xlr3a and Xlr3b, defining a new X-linked lymphocyte-regulated Xlr gene subfamily. Bergsagel PL, et al. Gene, 1994 Dec 15. PMID 7821804
    2. Xlr3b is a new imprinted candidate for X-linked parent-of-origin effects on cognitive function in mice. Davies W, et al. Nat Genet, 2005 Jun. PMID 15908950
    3. Identification of a cluster of X-linked imprinted genes in mice. Raefski AS, et al. Nat Genet, 2005 Jun. PMID 15908953
    4. Histone H3 lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesis. Inagawa M, et al. Mech Dev, 2013 Nov-Dec. PMID 23892084
    5. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102490, MGC130195, MGC130233, MGC156362, MGC156363

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatid development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in synaptonemal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    X-linked lymphocyte-regulated protein 3A
    Names
    X-linked B-cell surface antigen 3a
    X-linked lymphocyte regulated 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110784.1 → NP_001104254.1  X-linked lymphocyte-regulated protein 3A

      See identical proteins and their annotated locations for NP_001104254.1

      Status: VALIDATED

      Source sequence(s)
      AW556788, BC107255, BQ885410, BX813330, CJ302076, DV662513
      Consensus CDS
      CCDS53092.1
      UniProtKB/Swiss-Prot
      Q61244, Q61806
      UniProtKB/TrEMBL
      Q99L59
      Related
      ENSMUSP00000074199.6, ENSMUST00000074619.6
      Conserved Domains (1) summary
      pfam04803
      Location:72 → 187
      Cor1; Cor1/Xlr/Xmr conserved region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      72129899..72140701 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247556.1 → XP_011245858.1  X-linked lymphocyte-regulated protein 3A isoform X1

      See identical proteins and their annotated locations for XP_011245858.1

      UniProtKB/Swiss-Prot
      Q60595, Q61244, Q61806
      UniProtKB/TrEMBL
      Q78PE0
      Related
      ENSMUSP00000110170.3, ENSMUST00000114524.9
      Conserved Domains (1) summary
      pfam04803
      Location:75 → 203
      Cor1; Cor1/Xlr/Xmr conserved region

    2. XM_011247557.1 → XP_011245859.1  X-linked lymphocyte-regulated protein 3A isoform X1

      See identical proteins and their annotated locations for XP_011245859.1

      UniProtKB/Swiss-Prot
      Q60595, Q61244, Q61806
      UniProtKB/TrEMBL
      Q78PE0
      Conserved Domains (1) summary
      pfam04803
      Location:75 → 203
      Cor1; Cor1/Xlr/Xmr conserved region

    3. XM_011247559.1 → XP_011245861.1  X-linked lymphocyte-regulated protein 3A isoform X3

      See identical proteins and their annotated locations for XP_011245861.1

      Conserved Domains (1) summary
      pfam04803
      Location:1 → 116
      Cor1; Cor1/Xlr/Xmr conserved region

    4. XM_011247558.3 → XP_011245860.1  X-linked lymphocyte-regulated protein 3A isoform X2

      See identical proteins and their annotated locations for XP_011245860.1

      Conserved Domains (1) summary
      pfam04803
      Location:75 → 179
      Cor1; Cor1/Xlr/Xmr conserved region

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_011726.1: Suppressed sequence

      Description
      NM_011726.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q60595.1 GenPept UniProtKB/Swiss-Prot:Q60595

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