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    Oaz2 ornithine decarboxylase antizyme 2 [ Mus musculus (house mouse) ]

    Gene ID: 18247, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Oaz2provided by MGI
    Official Full Name
    ornithine decarboxylase antizyme 2provided by MGI
    Primary source
    MGI:MGI:109492
    See related
    Ensembl:ENSMUSG00000040652 AllianceGenome:MGI:109492
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AZ2; AZ-2; Sez15; Oaz2-ps
    Summary
    The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo; however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2014]
    Expression
    Ubiquitous expression in lung adult (RPKM 83.1), CNS E18 (RPKM 58.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Oaz2 in Genome Data Viewer
    Location:
    9 C; 9 35.45 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (65583830..65597582)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (65676548..65690300)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_24463 Neighboring gene STARR-seq mESC enhancer starr_24464 Neighboring gene predicted pseudogene 10144 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:65469333-65469516 Neighboring gene STARR-seq mESC enhancer starr_24467 Neighboring gene RNA binding protein with multiple splicing 2 Neighboring gene STARR-positive B cell enhancer ABC_E9768 Neighboring gene STARR-seq mESC enhancer starr_24469 Neighboring gene zinc finger protein 609 Neighboring gene STARR-seq mESC enhancer starr_24471 Neighboring gene ATP synthase subunit f, mitochondrial-like Neighboring gene thyroid hormone receptor interactor 4 Neighboring gene ribosomal protein S2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Subcellular localization and phosphorylation of antizyme 2. Murai N, et al. J Cell Biochem, 2009 Nov 1. PMID 19725046
    2. Developmental alterations in expression and subcellular localization of antizyme and antizyme inhibitor and their functional importance in the murine mammary gland. Murakami Y, et al. Amino Acids, 2010 Feb. PMID 19997757
    3. A second mammalian antizyme: conservation of programmed ribosomal frameshifting. Ivanov IP, et al. Genomics, 1998 Sep 1. PMID 9782076
    4. Antizyme expression: a subversion of triplet decoding, which is remarkably conserved by evolution, is a sensor for an autoregulatory circuit. Ivanov IP, et al. Nucleic Acids Res, 2000 Sep 1. PMID 10954585, Free PMC Article
    5. Molecular characterization of seizure-related genes isolated by differential screening. Kajiwara K, et al. Biochem Biophys Res Commun, 1996 Feb 27. PMID 8645260

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The level of AZ2 mRNA decreased during mammary gland development.
      Title: Developmental alterations in expression and subcellular localization of antizyme and antizyme inhibitor and their functional importance in the murine mammary gland.
    2. The protein product is generated using polyamine-regulated programmed ribosomal frameshifting.
      Title: A second mammalian antizyme: conservation of programmed ribosomal frameshifting.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ornithine decarboxylase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ornithine decarboxylase inhibitor activity IGI
    Inferred from Genetic Interaction
    more info
    		  
    enables ornithine decarboxylase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ornithine decarboxylase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of polyamine transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		  
    involved_in polyamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within polyamine metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of intracellular protein transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in viral translational frameshifting IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ornithine decarboxylase antizyme 2
    Names
    ODC-Az 2
    antizyme 2
    seizure-related protein 15

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301307.1 → NP_001288236.1  ornithine decarboxylase antizyme 2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate, in-frame acceptor splice site at the second exon compared to variant 1. The resulting isoform (2) is one amino acid shorter than isoform 1.
      Source sequence(s)
      AK169243, BC083114, CJ072367
      Conserved Domains (1) summary
      pfam02100
      Location:97 → 180
      ODC_AZ; Ornithine decarboxylase antizyme

    2. NM_010952.3 → NP_035082.1  ornithine decarboxylase antizyme 2 isoform 1

      See identical proteins and their annotated locations for NP_035082.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK169243, BC083114
      Consensus CDS
      CCDS57683.1
      UniProtKB/Swiss-Prot
      O08608
      Related
      ENSMUSP00000136914.2, ENSMUST00000153700.9
      Conserved Domains (1) summary
      pfam02100
      Location:98 → 181
      ODC_AZ; Ornithine decarboxylase antizyme

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      65583830..65597582
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08608.2 GenPept UniProtKB/Swiss-Prot:O08608

    Gene LinkOut

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