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    Lair1 leukocyte-associated Ig-like receptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 52855, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Lair1provided by MGI
    Official Full Name
    leukocyte-associated Ig-like receptor 1provided by MGI
    Primary source
    MGI:MGI:105492
    See related
    Ensembl:ENSMUSG00000055541 AllianceGenome:MGI:105492
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lair-1; D7Bwg0421e; 5133400O11Rik
    Summary
    Predicted to be involved in immune response-regulating signaling pathway. Predicted to be active in plasma membrane. Orthologous to several human genes including LAIR1 (leukocyte associated immunoglobulin like receptor 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in spleen adult (RPKM 2.8), frontal lobe adult (RPKM 1.2) and 25 other tissues See more
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    Genomic context

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    See Lair1 in Genome Data Viewer
    Location:
    7 A1; 7 2.31 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (4010072..4076566, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (4007073..4073567, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 7363 Neighboring gene STARR-seq mESC enhancer starr_17916 Neighboring gene predicted gene 15928 Neighboring gene STARR-seq mESC enhancer starr_17917 Neighboring gene RIKEN cDNA 9430041J12 gene Neighboring gene predicted gene, 23741 Neighboring gene STARR-seq mESC enhancer starr_17919 Neighboring gene RIKEN cDNA D030047H15 gene Neighboring gene tweety family member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Impaired LAIR-1-mediated immune control due to collagen degradation in fibrosis. Carvalheiro T, et al. J Autoimmun, 2024 Jun. PMID 38696927
    2. Mouse leukocyte-associated Ig-like receptor-1 (mLAIR-1) functions as an inhibitory collagen-binding receptor on immune cells. Lebbink RJ, et al. Int Immunol, 2007 Aug. PMID 17702987
    3. Mice Lacking the Inhibitory Collagen Receptor LAIR-1 Exhibit a Mild Thrombocytosis and Hyperactive Platelets. Smith CW, et al. Arterioscler Thromb Vasc Biol, 2017 May. PMID 28336561
    4. The Role of Leukocyte-Associated Ig-like Receptor-1 in Suppressing Collagen-Induced Arthritis. Kim S, et al. J Immunol, 2017 Oct 15. PMID 28887430, Free PMC Article
    5. Leukocyte-Associated Ig-like Receptor 1 Inhibits T(h)1 Responses but Is Required for Natural and Induced Monocyte-Dependent T(h)17 Responses. Agashe VV, et al. J Immunol, 2018 Jul 15. PMID 29884698, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Impaired LAIR-1-mediated immune control due to collagen degradation in fibrosis.
      Title: Impaired LAIR-1-mediated immune control due to collagen degradation in fibrosis.
    2. Lupus autoantibodies initiate neuroinflammation sustained by continuous HMGB1:RAGE signaling and reversed by increased LAIR-1 expression.
      Title: Lupus autoantibodies initiate neuroinflammation sustained by continuous HMGB1:RAGE signaling and reversed by increased LAIR-1 expression.
    3. 1,25-Dihydroxyvitamin D3 and 20-Hydroxyvitamin D3 Upregulate LAIR-1 and Attenuate Collagen Induced Arthritis.
      Title: 1,25-Dihydroxyvitamin D3 and 20-Hydroxyvitamin D3 Upregulate LAIR-1 and Attenuate Collagen Induced Arthritis.
    4. Leukocyte-associated immunoglobulin-like receptor 1 inhibits T-cell signaling by decreasing protein phosphorylation in the T-cell signaling pathway.
      Title: Leukocyte-associated immunoglobulin-like receptor 1 inhibits T-cell signaling by decreasing protein phosphorylation in the T-cell signaling pathway.
    5. collagen degradation fragments inhibit osteoclast formation acting through LAIR-1, providing a novel mechanism for the physiologically-relevant negative control of osteoclastogenesis
      Title: Collagen type I degradation fragments act through the collagen receptor LAIR-1 to provide a negative feedback for osteoclast formation.
    6. absence of LAIR-1 in myocardial infarct mice does not influence infarct size, inflammation, fibrosis or adverse cardiac remodelling.
      Title: Leukocyte-Associated Immunoglobulin-like Receptor-1 is regulated in human myocardial infarction but its absence does not affect infarct size in mice.
    7. this study shows that LAIR1 inhibits Th1 Responses but Is required for natural and induced monocyte-dependent Th17 responses
      Title: Leukocyte-Associated Ig-like Receptor 1 Inhibits T(h)1 Responses but Is Required for Natural and Induced Monocyte-Dependent T(h)17 Responses.
    8. these data demonstrate that collagen can suppress the T cell cytokine response through the action of LAIR-1, and that LAIR-1-/- mice develop more severe arthritis
      Title: The Role of Leukocyte-Associated Ig-like Receptor-1 in Suppressing Collagen-Induced Arthritis.
    9. LAIR-1 in megakaryocytes leads to increased Src family kinase activity and downstream signaling in response to collagen that is transmitted to platelets, rendering them hyper-reactive specifically to agonists that signal through Syk tyrosine kinases.
      Title: Mice Lacking the Inhibitory Collagen Receptor LAIR-1 Exhibit a Mild Thrombocytosis and Hyperactive Platelets.
    10. The LAIR1-SHP-1-CAMK1-CREB pathway sustains the survival and self-renewal of AML stem cells.
      Title: The ITIM-containing receptor LAIR1 is essential for acute myeloid leukaemia development.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (4)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in immune response-regulating signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    leukocyte-associated immunoglobulin-like receptor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113474.1 → NP_001106945.1  leukocyte-associated immunoglobulin-like receptor 1 isoform a precursor

      See identical proteins and their annotated locations for NP_001106945.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (a) encodes the longest isoform (a).
      Source sequence(s)
      AK033472, AK044465, AK050281, BY284244, BY515495
      Consensus CDS
      CCDS51969.1
      UniProtKB/Swiss-Prot
      Q80UN5, Q8BG84, Q8BHB6, Q8BRR6, Q8C6N8, Q8CEP5
      Related
      ENSMUSP00000083589.4, ENSMUST00000086401.10
      Conserved Domains (1) summary
      cl11960
      Location:27 → 118
      Ig; Immunoglobulin domain

    2. NM_001302675.1 → NP_001289604.1  leukocyte-associated immunoglobulin-like receptor 1 isoform e precursor

      See identical proteins and their annotated locations for NP_001289604.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (e) lacks an in-frame exon in the coding region compared to variant a. The encoded isoform (e) is shorter than isoform a.
      Source sequence(s)
      AC161037, AK033472, AY392766, BY284244, BY515495
      Consensus CDS
      CCDS80654.1
      Related
      ENSMUSP00000104241.3, ENSMUST00000108600.9
      Conserved Domains (1) summary
      cl11960
      Location:27 → 118
      Ig; Immunoglobulin domain

    3. NM_001302676.1 → NP_001289605.1  leukocyte-associated immunoglobulin-like receptor 1 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (c) lacks two in-frame exons in the coding region compared to variant a. It encodes isoform c, which is shorter than isoform a.
      Source sequence(s)
      AC161037, AK033472, BY204263, BY284244, BY515495
      UniProtKB/Swiss-Prot
      Q8BG84

    4. NM_001302677.1 → NP_001289606.1  leukocyte-associated immunoglobulin-like receptor 1 isoform d precursor

      See identical proteins and their annotated locations for NP_001289606.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (d) lacks two in-frame exons in the coding region compared to variant a. It encodes isoform d, which is shorter than isoform a.
      Source sequence(s)
      AC161037, AK033472, AY392765, BY284244, BY515495
      Consensus CDS
      CCDS85202.1
      UniProtKB/Swiss-Prot
      Q8BG84
      Related
      ENSMUSP00000145940.2, ENSMUST00000205296.2

    5. NM_001302681.1 → NP_001289610.1  leukocyte-associated immunoglobulin-like receptor 1 isoform f

      See identical proteins and their annotated locations for NP_001289610.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (f) differs in the 5' UTR, uses an alternate splice site at an internal exon, and initiates translation at an alternate start codon compared to variant a. The encoded isoform (f) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AC161037, AK033472, AK054158, AY392763, BY284244, BY515495
      Conserved Domains (1) summary
      cl11960
      Location:22 → 113
      Ig; Immunoglobulin domain

    6. NM_001302682.1 → NP_001289611.1  leukocyte-associated immunoglobulin-like receptor 1 isoform g

      See identical proteins and their annotated locations for NP_001289611.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (g) differs in the 5' UTR, initiates translation at an alternate start codon, and has multiple coding region differences, one of which results in a frameshift in the 3' coding region compared to variant a. The encoded isoform (g) has a distinct N-terminus and a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC161037, AK033472, AK054158, BY284244, BY515495
      UniProtKB/Swiss-Prot
      Q8BG84
      Conserved Domains (1) summary
      cl11960
      Location:22 → 113
      Ig; Immunoglobulin domain

    7. NM_001302683.1 → NP_001289612.1  leukocyte-associated immunoglobulin-like receptor 1 isoform h

      See identical proteins and their annotated locations for NP_001289612.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (h) differs in the 5'UTR, has multiple coding region differences, and initiates translation at an alternate start codon compared to variant a. The encoded isoform (h) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AC161037, AK033472, AK043664, BY284244, BY515495
      UniProtKB/Swiss-Prot
      Q8BG84

    8. NM_178611.6 → NP_848726.1  leukocyte-associated immunoglobulin-like receptor 1 isoform b

      See identical proteins and their annotated locations for NP_848726.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (b) lacks an in-frame exon in the coding region compared to variant a. It encodes isoform b, which is shorter than isoform a.
      Source sequence(s)
      AK033472, AK050281, BY284244, BY515495
      Consensus CDS
      CCDS20729.1
      UniProtKB/Swiss-Prot
      Q8BG84
      Related
      ENSMUSP00000070712.6, ENSMUST00000068865.13

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      4010072..4076566 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540179.5 → XP_006540242.1  leukocyte-associated immunoglobulin-like receptor 1 isoform X2

      See identical proteins and their annotated locations for XP_006540242.1

      Conserved Domains (1) summary
      cl11960
      Location:22 → 113
      Ig; Immunoglobulin domain

    2. XM_006540176.4 → XP_006540239.1  leukocyte-associated immunoglobulin-like receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_006540239.1

      UniProtKB/Swiss-Prot
      Q80UN5, Q8BG84, Q8BHB6, Q8BRR6, Q8C6N8, Q8CEP5
      Conserved Domains (1) summary
      cl11960
      Location:27 → 118
      Ig; Immunoglobulin domain

    3. XM_006540175.4 → XP_006540238.1  leukocyte-associated immunoglobulin-like receptor 1 isoform X1

      See identical proteins and their annotated locations for XP_006540238.1

      UniProtKB/Swiss-Prot
      Q80UN5, Q8BG84, Q8BHB6, Q8BRR6, Q8C6N8, Q8CEP5
      Conserved Domains (1) summary
      cl11960
      Location:27 → 118
      Ig; Immunoglobulin domain

    4. XM_036153240.1 → XP_036009133.1  leukocyte-associated immunoglobulin-like receptor 1 isoform X3

      Conserved Domains (2) summary
      cd00096
      Location:18 → 21
      Ig; Ig strand A [structural motif]
      cl11960
      Location:18 → 106
      Ig; Immunoglobulin domain

    5. XM_006540183.5 → XP_006540246.1  leukocyte-associated immunoglobulin-like receptor 1 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BG84.1 GenPept UniProtKB/Swiss-Prot:Q8BG84

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