Xiap X-linked inhibitor of apoptosis [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Xiapprovided by MGI
Official Full Name: X-linked inhibitor of apoptosisprovided by MGI
Primary source: MGI:MGI:107572
See related: Ensembl:ENSMUSG00000025860 AllianceGenome:MGI:107572
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Aipa; Api3; IAP3; MIHA; Birc4; ILP-1; 1110015C02Rik
Summary: The protein encoded by this gene is a member of the inhibitor of apoptosis (IAP) family of proteins. While first identified for its role in blocking apoptosis, this protein modulates many other signaling processes including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) pathways and inflammatory responses. This protein blocks apoptosis by binding and inhibiting target caspases after they have been activated. Binding occurs to some, but not all, caspases. This protein has several conserved regions, including baculoviral IAP repeat (BIR) motifs and a RING finger E3 ligase domain. In humans, mutations in this gene are linked to immunodeficiency in X-linked lymphoproliferative syndrome type-2 (XLP-2). A pseudogene of this gene is found on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Expression: Ubiquitous expression in cerebellum adult (RPKM 7.1), bladder adult (RPKM 6.9) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A4; X 23.19 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (41148483..41198541)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (42059613..42109664)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

XIAP-mediated degradation of IFT88 disrupts HSC cilia to stimulate HSC activation and liver fibrosis.
Title: XIAP-mediated degradation of IFT88 disrupts HSC cilia to stimulate HSC activation and liver fibrosis.
Overexpression of the X-Linked Inhibitor of Apoptosis Protein (XIAP) in Neurons Improves Cell Survival and the Functional Outcome after Traumatic Spinal Cord Injury.
Title: Overexpression of the X-Linked Inhibitor of Apoptosis Protein (XIAP) in Neurons Improves Cell Survival and the Functional Outcome after Traumatic Spinal Cord Injury.
XIAP promotes melanoma growth by inducing tumour neutrophil infiltration.
Title: XIAP promotes melanoma growth by inducing tumour neutrophil infiltration.
Deficiency in X-linked inhibitor of apoptosis protein promotes susceptibility to microbial triggers of intestinal inflammation.
Title: Deficiency in X-linked inhibitor of apoptosis protein promotes susceptibility to microbial triggers of intestinal inflammation.
XIAP prevents TNF-driven inflammation in the terminal ileum of mice. In Xiap-/- mice, TNFR1 signaling kills Paneth cells and TNFR1/TNFR2 signaling kills dendritic cells. Together this drives dysbiosis.
Title: XIAP restrains TNF-driven intestinal inflammation and dysbiosis by promoting innate immune responses of Paneth and dendritic cells.
MiR-96 promotes myocardial infarction-induced apoptosis by targeting XIAP.
Title: MiR-96 promotes myocardial infarction-induced apoptosis by targeting XIAP.
XIAP inhibits gentamicin-induced hair cell damage and ototoxicity through the caspase-3/9 pathway.
Title: XIAP inhibits gentamicin-induced hair cell damage and ototoxicity through the caspase-3/9 pathway.
Enteroendocrine Progenitor Cell-Enriched miR-7 Regulates Intestinal Epithelial Proliferation in an Xiap-Dependent Manner.
Title: Enteroendocrine Progenitor Cell-Enriched miR-7 Regulates Intestinal Epithelial Proliferation in an Xiap-Dependent Manner.
SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L.
Title: SIVA-1 regulates apoptosis and synaptic function by modulating XIAP interaction with the death receptor antagonist FAIM-L.
Effects of XIAP on high fat diet-induced hepatic steatosis: a mechanism involving NLRP3 inflammasome and oxidative stress.
Title: Effects of XIAP on high fat diet-induced hepatic steatosis: a mechanism involving NLRP3 inflammasome and oxidative stress.

Submit: New GeneRIF Correction See all GeneRIFs (75)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

U36842 (e-PCR)
- UniSTS:125736

Birc4 (e-PCR), detects polymorphism
- UniSTS:141106

Birc4 (e-PCR), detects polymorphism
- UniSTS:141107

U88990 (e-PCR)
- UniSTS:160880

DXMit104 (e-PCR), detects polymorphism
- UniSTS:131993

NoName (e-PCR)
- UniSTS:238017

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
enables endopeptidase regulator activity	IEA Inferred from Electronic Annotation more info
enables endopeptidase regulator activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase binding	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase binding	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in defense response to bacterium	IEA Inferred from Electronic Annotation more info
involved_in inhibition of cysteine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inhibition of cysteine-type endopeptidase activity involved in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleotide-binding oligomerization domain containing 1 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in nucleotide-binding oligomerization domain containing 2 signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein linear polyubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of type I interferon production	IEA Inferred from Electronic Annotation more info
involved_in protein K63-linked ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of apoptosis involved in tissue homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IC Inferred by Curator more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase XIAP

Names: IAP homolog A; RING-type E3 ubiquitin transferase XIAP; X-linked IAP; baculoviral IAP repeat-containing protein 4; inhibitor of apoptosis protein 3

NP_001288568.1

EC 2.3.2.27

NP_001288570.1

EC 2.3.2.27

NP_033818.2

EC 2.3.2.27

XP_006541488.1

EC 2.3.2.27

XP_006541490.1

EC 2.3.2.27

XP_011249278.1

EC 2.3.2.27

XP_011249279.1

EC 2.3.2.27

XP_017173848.1

EC 2.3.2.27

XP_017173849.1

EC 2.3.2.27

XP_017173850.1

EC 2.3.2.27

XP_017173851.1

EC 2.3.2.27

XP_030107060.1

EC 2.3.2.27

XP_030107062.1

EC 2.3.2.27

XP_030107063.1

EC 2.3.2.27

XP_036017678.1

EC 2.3.2.27

XP_036017679.1

EC 2.3.2.27

XP_036017680.1

EC 2.3.2.27

XP_036017681.1

EC 2.3.2.27

XP_036017682.1

EC 2.3.2.27

XP_036017683.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001301639.1 → NP_001288568.1 E3 ubiquitin-protein ligase XIAP

See identical proteins and their annotated locations for NP_001288568.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AI848625, AK041844, AK147447, BC138528, BG091082, CD548741, CK389763, CN527460, CN535777

Consensus CDS

CCDS30098.1

UniProtKB/Swiss-Prot

A2BGY6, O08865, Q60989

Related

ENSMUSP00000110747.3, ENSMUST00000115095.9

Conserved Domains (4) summary

smart00238
Location:162 → 232

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:28 → 95

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd14395
Location:369 → 418

UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

cd16714
Location:435 → 496

RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
NM_001301641.1 → NP_001288570.1 E3 ubiquitin-protein ligase XIAP

See identical proteins and their annotated locations for NP_001288570.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AI848625, AK041844, AK147447, BC138528, BG091082, BX530028, CD548741, CK389763, CN527460, CN535777

Consensus CDS

CCDS30098.1

UniProtKB/Swiss-Prot

A2BGY6, O08865, Q60989

Related

ENSMUSP00000061074.4, ENSMUST00000055483.10

Conserved Domains (4) summary

smart00238
Location:162 → 232

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:28 → 95

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd14395
Location:369 → 418

UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

cd16714
Location:435 → 496

RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
NM_009688.3 → NP_033818.2 E3 ubiquitin-protein ligase XIAP

See identical proteins and their annotated locations for NP_033818.2

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AI848625, AK041844, AK147447, BC138528, BG091082, CD548741, CJ111937, CJ126958, CK389763, CN527460, CN535777

Consensus CDS

CCDS30098.1

UniProtKB/Swiss-Prot

A2BGY6, O08865, Q60989

Related

ENSMUSP00000110746.2, ENSMUST00000115094.8

Conserved Domains (4) summary

smart00238
Location:162 → 232

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:28 → 95

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd14395
Location:369 → 418

UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

cd16714
Location:435 → 496

RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

RNA

NR_125870.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.

Source sequence(s)

AI848625, AK041844, AK147447, BB663325, BC138528, BG091082, CD548741, CK389763, CN527460, CN535777

Related

ENSMUST00000145065.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

41148483..41198541

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017318359.3 → XP_017173848.1 E3 ubiquitin-protein ligase XIAP isoform X2

UniProtKB/Swiss-Prot

A2BGY6, O08865, Q60989

Conserved Domains (4) summary

smart00238
Location:162 → 232

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:28 → 95

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd14395
Location:369 → 418

UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

cd16714
Location:435 → 496

RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
XM_017318362.3 → XP_017173851.1 E3 ubiquitin-protein ligase XIAP isoform X2

UniProtKB/Swiss-Prot

A2BGY6, O08865, Q60989

Conserved Domains (4) summary

smart00238
Location:162 → 232

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:28 → 95

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd14395
Location:369 → 418

UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

cd16714
Location:435 → 496

RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
XM_017318360.3 → XP_017173849.1 E3 ubiquitin-protein ligase XIAP isoform X2

UniProtKB/Swiss-Prot

A2BGY6, O08865, Q60989

Conserved Domains (4) summary

smart00238
Location:162 → 232

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:28 → 95

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd14395
Location:369 → 418

UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

cd16714
Location:435 → 496

RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
XM_030251203.2 → XP_030107063.1 E3 ubiquitin-protein ligase XIAP isoform X2

UniProtKB/Swiss-Prot

A2BGY6, O08865, Q60989

Conserved Domains (4) summary

smart00238
Location:162 → 232

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:28 → 95

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd14395
Location:369 → 418

UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

cd16714
Location:435 → 496

RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
XM_036161787.1 → XP_036017680.1 E3 ubiquitin-protein ligase XIAP isoform X2

UniProtKB/Swiss-Prot

A2BGY6, O08865, Q60989

Conserved Domains (4) summary

smart00238
Location:162 → 232

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:28 → 95

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd14395
Location:369 → 418

UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

cd16714
Location:435 → 496

RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
XM_036161786.1 → XP_036017679.1 E3 ubiquitin-protein ligase XIAP isoform X2

UniProtKB/Swiss-Prot

A2BGY6, O08865, Q60989

Conserved Domains (4) summary

smart00238
Location:162 → 232

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:28 → 95

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd14395
Location:369 → 418

UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

cd16714
Location:435 → 496

RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
XM_030251202.2 → XP_030107062.1 E3 ubiquitin-protein ligase XIAP isoform X2

UniProtKB/Swiss-Prot

A2BGY6, O08865, Q60989

Conserved Domains (4) summary

smart00238
Location:162 → 232

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:28 → 95

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd14395
Location:369 → 418

UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

cd16714
Location:435 → 496

RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
XM_036161788.1 → XP_036017681.1 E3 ubiquitin-protein ligase XIAP isoform X3

Conserved Domains (3) summary

smart00238
Location:214 → 284

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:80 → 147

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd14395
Location:421 → 470

UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
XM_011250976.4 → XP_011249278.1 E3 ubiquitin-protein ligase XIAP isoform X1

Conserved Domains (4) summary

smart00238
Location:214 → 284

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:80 → 147

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd14395
Location:421 → 470

UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

cd16714
Location:487 → 548

RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
XM_036161790.1 → XP_036017683.1 E3 ubiquitin-protein ligase XIAP isoform X4

Conserved Domains (3) summary

smart00238
Location:162 → 232

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:28 → 95

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd14395
Location:369 → 418

UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
XM_017318361.2 → XP_017173850.1 E3 ubiquitin-protein ligase XIAP isoform X2

UniProtKB/Swiss-Prot

A2BGY6, O08865, Q60989

Conserved Domains (4) summary

smart00238
Location:162 → 232

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:28 → 95

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd14395
Location:369 → 418

UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

cd16714
Location:435 → 496

RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
XM_006541427.3 → XP_006541490.1 E3 ubiquitin-protein ligase XIAP isoform X2

See identical proteins and their annotated locations for XP_006541490.1

UniProtKB/Swiss-Prot

A2BGY6, O08865, Q60989

Conserved Domains (4) summary

smart00238
Location:162 → 232

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:28 → 95

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd14395
Location:369 → 418

UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

cd16714
Location:435 → 496

RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
XM_006541425.3 → XP_006541488.1 E3 ubiquitin-protein ligase XIAP isoform X2

See identical proteins and their annotated locations for XP_006541488.1

UniProtKB/Swiss-Prot

A2BGY6, O08865, Q60989

Conserved Domains (4) summary

smart00238
Location:162 → 232

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:28 → 95

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd14395
Location:369 → 418

UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

cd16714
Location:435 → 496

RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
XM_036161785.1 → XP_036017678.1 E3 ubiquitin-protein ligase XIAP isoform X2

UniProtKB/Swiss-Prot

A2BGY6, O08865, Q60989

Conserved Domains (4) summary

smart00238
Location:162 → 232

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:28 → 95

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd14395
Location:369 → 418

UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

cd16714
Location:435 → 496

RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
XM_030251200.2 → XP_030107060.1 E3 ubiquitin-protein ligase XIAP isoform X2

UniProtKB/Swiss-Prot

A2BGY6, O08865, Q60989

Conserved Domains (4) summary

smart00238
Location:162 → 232

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:28 → 95

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd14395
Location:369 → 418

UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

cd16714
Location:435 → 496

RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
XM_036161789.1 → XP_036017682.1 E3 ubiquitin-protein ligase XIAP isoform X4

Conserved Domains (3) summary

smart00238
Location:162 → 232

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:28 → 95

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd14395
Location:369 → 418

UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins
XM_011250977.4 → XP_011249279.1 E3 ubiquitin-protein ligase XIAP isoform X2

See identical proteins and their annotated locations for XP_011249279.1

UniProtKB/Swiss-Prot

A2BGY6, O08865, Q60989

Conserved Domains (4) summary

smart00238
Location:162 → 232

BIR; Baculoviral inhibition of apoptosis protein repeat

cd00022
Location:28 → 95

BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...

cd14395
Location:369 → 418

UBA_BIRC4_8; UBA domain found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins

cd16714
Location:435 → 496

RING-HC_BIRC4_8; RING finger, HC subclass, found in E3 ubiquitin-protein ligase XIAP, baculoviral IAP repeat-containing protein 8 (BIRC8) and similar proteins