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    Gmps guanine monophosphate synthase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295088, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Gmpsprovided by RGD
    Official Full Name
    guanine monophosphate synthaseprovided by RGD
    Primary source
    RGD:1310063
    See related
    EnsemblRapid:ENSRNOG00000051151 AllianceGenome:RGD:1310063
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables GMP synthase activity and enzyme binding activity. Involved in GMP salvage; response to L-cysteine; and response to xenobiotic stimulus. Predicted to be active in cytosol. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in acute myelomonocytic leukemia. Orthologous to human GMPS (guanine monophosphate synthase). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Testes (RPKM 378.3), Heart (RPKM 362.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gmps in Genome Data Viewer
    Location:
    2q31
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (150587824..150641564)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (148441369..148491908)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (154555967..154590662)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 3 open reading frame 33 Neighboring gene solute carrier family 33 member 1 Neighboring gene vomeronasal 2 receptor 44 Neighboring gene vomeronasal 2 receptor, 45

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Enzymes of purine metabolism in cancer. Weber G. Clin Biochem, 1983 Feb. PMID 6861338
    2. Enzymic programs of rat bone marrow and the impact of acivicin and tiazofurin. Prajda N, et al. Biochem Pharmacol, 1988 Mar 1. PMID 3345200
    3. Oncolytic activity and mechanism of action of a novel L-cysteine derivative, L-cysteine, ethyl ester, S-(N-methylcarbamate) monohydrochloride. Jayaram HN, et al. Cancer Chemother Pharmacol, 1990. PMID 2347042
    4. Human GMP synthetase. Protein purification, cloning, and functional expression of cDNA. Hirst M, et al. J Biol Chem, 1994 Sep 23. PMID 8089153
    5. Enhanced in vitro growth of glomerular cells derived from rats with immune-mediated mesangial injury. Harendza SG, et al. Exp Nephrol, 1993 Jan-Feb. PMID 8081953

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GMP synthase (glutamine-hydrolyzing) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GMP synthase (glutamine-hydrolyzing) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GMP synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GMP synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GMP synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GMP synthase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in GMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in GMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within GMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in GMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in GMP salvage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glutamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to L-cysteine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    GMP synthase [glutamine-hydrolyzing]
    Names
    GMP synthase
    GMP synthetase
    glutamine amidotransferase
    guanine monophosphate synthetase
    NP_001019925.1
    XP_038957944.1
    XP_038957945.1
    XP_063137657.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024754.1 → NP_001019925.1  GMP synthase [glutamine-hydrolyzing]

      See identical proteins and their annotated locations for NP_001019925.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098016
      UniProtKB/Swiss-Prot
      Q4V7C6
      UniProtKB/TrEMBL
      A0A0G2K2C2
      Related
      ENSRNOP00000109550.1, ENSRNOT00000167462.1
      Conserved Domains (1) summary
      PRK00074
      Location:28 → 693
      guaA; GMP synthase; Reviewed

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      150587824..150641564
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039102016.2 → XP_038957944.1  GMP synthase [glutamine-hydrolyzing] isoform X1

      UniProtKB/TrEMBL
      A0A0G2K2C2, A0A8L2R0S7
      Conserved Domains (1) summary
      PRK00074
      Location:69 → 734
      guaA; GMP synthase; Reviewed

    2. XM_063281587.1 → XP_063137657.1  GMP synthase [glutamine-hydrolyzing] isoform X1

      UniProtKB/TrEMBL
      A0A8L2R0S7

    3. XM_039102017.2 → XP_038957945.1  GMP synthase [glutamine-hydrolyzing] isoform X2

      UniProtKB/TrEMBL
      A6JVP6
      Conserved Domains (1) summary
      PRK00074
      Location:28 → 520
      guaA; GMP synthase; Reviewed
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V7C6.1 GenPept UniProtKB/Swiss-Prot:Q4V7C6

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