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    chn charlatan [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36678, updated on 10-May-2024

    Summary

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    Official Symbol
    chnprovided by FlyBase
    Official Full Name
    charlatanprovided by FlyBase
    Primary source
    FLYBASE:FBgn0015371
    Locus tag
    Dmel_CG11798
    See related
    AllianceGenome:FB:FBgn0015371
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Liang-1.13; CG11798; chl; Chn; clone 1.13; Dmel\CG11798; EPIL#6; EPIL6; l(2)02064; l(2)k04218; taco
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in several processes, including larval somatic muscle development; nervous system development; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including ectoderm; ectoderm anlage; extended germ band embryo; imaginal disc; and presumptive embryonic/larval system. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See chn in Genome Data Viewer
    Location:
    51E1-51E2; 2-74 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15115236..15144783)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11002741..11032288)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44457 Neighboring gene RNA polymerase II, I and III subunit K Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A splicing variant of Charlatan, a Drosophila REST-like molecule, preferentially localizes to axons. Yamasaki Y, et al. Biochem Biophys Res Commun, 2021 Nov 12. PMID 34536827
    2. Robust specification of sensory neurons by dual functions of charlatan, a Drosophila NRSF/REST-like repressor of extramacrochaetae and hairy. Yamasaki Y, et al. Genes Cells, 2011 Aug. PMID 21762412
    3. Drosophila Cellular Immunity Against Parasitoid Wasps: A Complex and Time-Dependent Process. Kim-Jo C, et al. Front Physiol, 2019. PMID 31156469, Free PMC Article
    4. Hindsight modulates Delta expression during Drosophila cone cell induction. Pickup AT, et al. Development, 2009 Mar. PMID 19234063
    5. Drosophila as a model for intractable epilepsy: gilgamesh suppresses seizures in para(bss1) heterozygote flies. Howlett IC, et al. G3 (Bethesda), 2013 Aug 7. PMID 23797108, Free PMC Article

    See all (92) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gene expression profiling identifies the zinc-finger protein Charlatan as a regulator of intestinal stem cells in Drosophila.
      Title: Gene expression profiling identifies the zinc-finger protein Charlatan as a regulator of intestinal stem cells in Drosophila.
    2. Chn is a dual functional regulator of transcription.
      Title: Robust specification of sensory neurons by dual functions of charlatan, a Drosophila NRSF/REST-like repressor of extramacrochaetae and hairy.
    3. Data show that isolated plasmatocytes can be triggered to differentiate into lamellocytes in vitro, either in response to Chn over-expression, or following activation of the JAK/STAT pathway.
      Title: Lineage tracing of lamellocytes demonstrates Drosophila macrophage plasticity.
    4. under EGF signaling, double negative regulation mediated by the Ebi/SMRTER corepressor complex and an NRSF/REST-like factor, Chn, maintains inductive activity in developing photoreceptor cells by promoting Dl expression
      Title: An NRSF/REST-like repressor downstream of Ebi/SMRTER/Su(H) regulates eye development in Drosophila.
    5. mutation decreases the accumulation of Sc in proneural clusters, affecting notum macrochaetae, overexpression enhances ac/sc
      Title: Charlatan, a Zn-finger transcription factor, establishes a novel level of regulation of the proneural achaete/scute genes of Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: 15119372-15127796 mobile_element_type = transposon:Tirant{}833

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in embryonic development via the syncytial blastoderm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in eye development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval somatic muscle development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in larval somatic muscle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of compound eye cone cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peripheral nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in progression of morphogenetic furrow involved in compound eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus HDA PubMed 
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    charlatan
    Names
    CG11798-PA
    CG11798-PB
    CG11798-PC
    CG11798-PD
    CG11798-PE
    CG11798-PF
    CG11798-PG
    CG11798-PH
    CG11798-PI
    chn-PA
    chn-PB
    chn-PC
    chn-PD
    chn-PE
    chn-PF
    chn-PG
    chn-PH
    chn-PI

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15115236..15144783
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001043082.2 → NP_001036547.1  charlatan, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036547.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZH6, Q0E968, Q5BHY4, Q7YU81, Q8T065, Q95RE7, Q9V788
      Conserved Domains (1) summary
      sd00017
      Location:307 → 327
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_206119.2 → NP_995841.1  charlatan, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995841.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7YU81
      Conserved Domains (1) summary
      sd00017
      Location:307 → 327
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001259402.2 → NP_001246331.1  charlatan, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246331.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7A3
      Conserved Domains (1) summary
      sd00017
      Location:307 → 327
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_001259405.2 → NP_001246334.1  charlatan, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246334.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7Q9
      Conserved Domains (1) summary
      sd00017
      Location:307 → 327
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. NM_001043081.2 → NP_001036546.1  charlatan, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036546.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7YU81
      Conserved Domains (1) summary
      sd00017
      Location:307 → 327
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. NM_001259403.2 → NP_001246332.1  charlatan, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246332.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7A3
      Conserved Domains (1) summary
      sd00017
      Location:307 → 327
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. NM_001259401.2 → NP_001246330.1  charlatan, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246330.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7Z6
      Conserved Domains (1) summary
      sd00017
      Location:307 → 327
      ZF_C2H2; C2H2 Zn finger [structural motif]

    8. NM_001259404.2 → NP_001246333.1  charlatan, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246333.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K876
      Conserved Domains (1) summary
      sd00017
      Location:307 → 327
      ZF_C2H2; C2H2 Zn finger [structural motif]

    9. NM_137169.4 → NP_611013.1  charlatan, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611013.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7YU81
      Related
      FBpp0086546
      Conserved Domains (1) summary
      sd00017
      Location:307 → 327
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K7A3 A0A0B4K7A3
    A0A0B4K7Q9 A0A0B4K7Q9
    A0A0B4K7Z6 A0A0B4K7Z6
    A0A0B4K876 A0A0B4K876
    Q7YU81.3 Q7YU81

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