Ptp4E Protein tyrosine phosphatase 4E [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Ptp4Eprovided by FlyBase
Official Full Name: Protein tyrosine phosphatase 4Eprovided by FlyBase
Primary source: FLYBASE:FBgn0004368
Locus tag: Dmel_CG6899
See related: AllianceGenome:FB:FBgn0004368
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 4E; CG6899; CT21187; Dmel\CG6899; DPTP4E; ptp4E; PtP4E; PTP4E; R-PTP 4E
Summary: Enables transmembrane receptor protein tyrosine phosphatase activity. Involved in branching involved in open tracheal system development; negative regulation of signal transduction; and nervous system development. Located in apical plasma membrane; axon; and neuronal cell body. Is expressed in several structures, including adult head; embryonic ventral epidermis; epithelium; gut section; and hindgut anlage. Human ortholog(s) of this gene implicated in angiosarcoma; breast angiosarcoma; carcinoma (multiple); central nervous system cancer (multiple); and sarcoma. Orthologous to human PTPRB (protein tyrosine phosphatase receptor type B). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 4D7-4D7; 1-9 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (4939128..4955916)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (4833161..4849949)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ptp4E controls the presynaptic abundance and activity of the vesicular monoamine transporter, which packages monoamine transmitters for synaptic release.
Title: Drosophila Ptp4E regulates vesicular packaging for monoamine-neuropeptide co-transmission.
Results describe a unique tracheal tubulogenesis phenotype caused by loss of both Drosophila type III receptor tyrosine phosphatases (RPTPs), Ptp4E and Ptp10D.
Title: Receptor tyrosine phosphatases control tracheal tube geometries through negative regulation of Egfr signaling.
Unlike Ptp10D, Ptp4E appears to be a relatively minor player in the control of axon guidance
Title: Redundancy and compensation in axon guidance: genetic analysis of the Drosophila Ptp10D/Ptp4E receptor tyrosine phosphatase subfamily.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm1954 (e-PCR)
- UniSTS:5851

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables transmembrane receptor protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in branching involved in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in central nervous system development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in motor neuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of fibroblast growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in open tracheal system development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein tyrosine phosphatase 4E

Names: CG6899-PA; CG6899-PB; CG6899-PC; CG6899-PD; CG6899-PF; CG6899-PG; CG6899-PH; Ptp4E-PA; Ptp4E-PB; Ptp4E-PC; Ptp4E-PD; Ptp4E-PF; Ptp4E-PG; Ptp4E-PH

NP_001162669.1

EC 3.1.3.-

EC 3.1.3.48

NP_001162670.1

EC 3.1.3.-

EC 3.1.3.48

NP_001162671.2

EC 3.1.3.-

EC 3.1.3.48

NP_001162672.1

EC 3.1.3.-

EC 3.1.3.48

NP_001284875.1

EC 3.1.3.-

EC 3.1.3.48

NP_525076.2

EC 3.1.3.-

EC 3.1.3.48

NP_726967.1

EC 3.1.3.-

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

4939128..4955916

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001169198.2 → NP_001162669.1 protein tyrosine phosphatase 4E, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162669.1

Status: REVIEWED

UniProtKB/TrEMBL

Q24495, Q9W4F5

Conserved Domains (5) summary

smart00194
Location:1329 → 1582

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:1355 → 1582

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:620 → 706

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:247 → 328

fn3; Fibronectin type III domain

cl06408
Location:1106 → 1248

UP_III_II; Uroplakin IIIb, IIIa and II
NM_080337.3 → NP_525076.2 protein tyrosine phosphatase 4E, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_525076.2

Status: REVIEWED

UniProtKB/TrEMBL

Q24495, Q9W4F5

Related

FBpp0070692

Conserved Domains (5) summary

smart00194
Location:1329 → 1582

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:1355 → 1582

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:620 → 706

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:247 → 328

fn3; Fibronectin type III domain

cl06408
Location:1106 → 1248

UP_III_II; Uroplakin IIIb, IIIa and II
NM_001169200.2 → NP_001162671.2 protein tyrosine phosphatase 4E, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162671.2

Status: REVIEWED

UniProtKB/TrEMBL

E1JJE4, Q24495

Conserved Domains (5) summary

smart00194
Location:1329 → 1582

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:1355 → 1582

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:620 → 706

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:247 → 328

fn3; Fibronectin type III domain

cl06408
Location:1106 → 1248

UP_III_II; Uroplakin IIIb, IIIa and II
NM_001297946.1 → NP_001284875.1 protein tyrosine phosphatase 4E, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284875.1

Status: REVIEWED

UniProtKB/TrEMBL

Q24495, X2JCK2

Conserved Domains (5) summary

cd00063
Location:620 → 706

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14548
Location:1358 → 1579

R3-PTPc; catalytic domain of R3 subfamily receptor-type tyrosine-protein phosphatases and similar proteins

pfam00041
Location:902 → 978

fn3; Fibronectin type III domain

pfam18861
Location:1127 → 1247

PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J

cl21522
Location:345 → 417

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_167024.3 → NP_726967.1 protein tyrosine phosphatase 4E, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726967.1

Status: REVIEWED

UniProtKB/TrEMBL

Q24495, Q8IRS0

Related

FBpp0070693

Conserved Domains (5) summary

smart00194
Location:1329 → 1582

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:1355 → 1582

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:620 → 706

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:247 → 328

fn3; Fibronectin type III domain

cl06408
Location:1106 → 1248

UP_III_II; Uroplakin IIIb, IIIa and II
NM_001169201.2 → NP_001162672.1 protein tyrosine phosphatase 4E, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162672.1

Status: REVIEWED

UniProtKB/TrEMBL

Q24495, Q9W4F5

Conserved Domains (5) summary

smart00194
Location:1329 → 1582

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:1355 → 1582

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:620 → 706

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:247 → 328

fn3; Fibronectin type III domain

cl06408
Location:1106 → 1248

UP_III_II; Uroplakin IIIb, IIIa and II
NM_001169199.2 → NP_001162670.1 protein tyrosine phosphatase 4E, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001162670.1

Status: REVIEWED

UniProtKB/TrEMBL

Q24495, Q9W4F5

Conserved Domains (5) summary

smart00194
Location:1329 → 1582

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:1355 → 1582

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:620 → 706

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:247 → 328

fn3; Fibronectin type III domain

cl06408
Location:1106 → 1248

UP_III_II; Uroplakin IIIb, IIIa and II