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    CYP4F2 cytochrome P450 family 4 subfamily F member 2 [ Homo sapiens (human) ]

    Gene ID: 8529, updated on 2-Nov-2024

    Summary

    Official Symbol
    CYP4F2provided by HGNC
    Official Full Name
    cytochrome P450 family 4 subfamily F member 2provided by HGNC
    Primary source
    HGNC:HGNC:2645
    See related
    Ensembl:ENSG00000186115 MIM:604426; AllianceGenome:HGNC:2645
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CPF2
    Summary
    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in liver (RPKM 63.5), small intestine (RPKM 42.7) and 2 other tissues See more
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    Genomic context

    See CYP4F2 in Genome Data Viewer
    Location:
    19p13.12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (15878023..15898074, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (16009384..16029310, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (15988833..16008884, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene C-type lectin domain family 4 member O, pseudogene Neighboring gene Sharpr-MPRA regulatory region 12980 Neighboring gene cytochrome P450 family 4 subfamily F member 36, pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr19:16002896-16004095 Neighboring gene RNA polymerase mitochondrial pseudogene Neighboring gene RNA polymerase mitochondrial pseudogene Neighboring gene inositol polyphosphate multikinase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide assessment of variability in human serum metabolism.
    EBI GWAS Catalog
    A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose.
    EBI GWAS Catalog
    A genome-wide association study of acenocoumarol maintenance dosage.
    EBI GWAS Catalog
    Genome-wide association study identifies common variants associated with circulating vitamin E levels.
    EBI GWAS Catalog
    Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanese.
    EBI GWAS Catalog
    Genome-wide association study identifies three common variants associated with serologic response to vitamin E supplementation in men.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies for circulating phylloquinone concentrations.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 20-aldehyde-leukotriene B4 20-monooxygenase activity TAS
    Traceable Author Statement
    more info
     
    enables 20-hydroxy-leukotriene B4 omega oxidase activity TAS
    Traceable Author Statement
    more info
     
    enables alkane 1-monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables alpha-tocopherol omega-hydroxylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables arachidonate epoxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables arachidonate omega-hydroxylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables aromatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables leukotriene-B4 20-monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables leukotriene-B4 20-monooxygenase activity TAS
    Traceable Author Statement
    more info
     
    enables long-chain fatty acid omega-hydroxylase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables monooxygenase activity TAS
    Traceable Author Statement
    more info
     
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in arachidonate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in blood coagulation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in epoxygenase P450 pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in fatty acid omega-oxidation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in icosanoid metabolic process TAS
    Traceable Author Statement
    more info
     
    involved_in leukotriene B4 catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in leukotriene metabolic process TAS
    Traceable Author Statement
    more info
     
    involved_in long-chain fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in menaquinone catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of icosanoid secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in omega-hydroxylase P450 pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in omega-hydroxylase P450 pathway TAS
    Traceable Author Statement
    more info
     
    involved_in phylloquinone catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phylloquinone catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of icosanoid secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in pressure natriuresis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in renal water homeostasis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in sodium ion homeostasis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in very long-chain fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in vitamin E metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in vitamin K catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in xenobiotic metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cytochrome P450 4F2
    Names
    20-HETE synthase
    20-hydroxyeicosatetraenoic acid synthase
    CYPIVF2
    arachidonic acid omega-hydroxylase
    cytochrome P450, family 4, subfamily F, polypeptide 2
    cytochrome P450, subfamily IVF, polypeptide 2
    cytochrome P450-LTB-omega
    docosahexaenoic acid omega-hydroxylase
    leukotriene-B(4) 20-monooxygenase 1
    leukotriene-B(4) omega-hydroxylase 1
    phylloquinone omega-hydroxylase CYP4F2
    NP_001073.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007971.2 RefSeqGene

      Range
      5001..25052
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001082.5NP_001073.3  cytochrome P450 4F2 precursor

      See identical proteins and their annotated locations for NP_001073.3

      Status: REVIEWED

      Source sequence(s)
      AC004791, AK290790, BC067439, DC362034, U02388
      Consensus CDS
      CCDS12336.1
      UniProtKB/Swiss-Prot
      A0A024R7K3, A8K425, B4DV75, P78329, Q16677, Q6NWT4, Q6NWT6, Q9NNZ0, Q9UIU8
      UniProtKB/TrEMBL
      A0A0A0MQR0
      Related
      ENSP00000221700.3, ENST00000221700.11
      Conserved Domains (2) summary
      pfam00067
      Location:52515
      p450; Cytochrome P450
      pfam13779
      Location:457
      DUF4175; Domain of unknown function (DUF4175)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      15878023..15898074 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      16009384..16029310 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)