Nfix nuclear factor I/X [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nfixprovided by MGI
Official Full Name: nuclear factor I/Xprovided by MGI
Primary source: MGI:MGI:97311
See related: Ensembl:ENSMUSG00000001911 AllianceGenome:MGI:97311
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CTF; NF1-X; NFI-X; NF-I/X
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including learning or memory; nervous system development; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including exit from mitosis; myeloid leukocyte differentiation; and nervous system development. Is active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study Scheuermann's disease and Sotos syndrome 2. Human ortholog(s) of this gene implicated in Marshall-Smith syndrome and Sotos syndrome 2. Orthologous to human NFIX (nuclear factor I X). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in lung adult (RPKM 15.5), limb E14.5 (RPKM 14.4) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C3; 8 41.02 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (85431341..85527086, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (84704712..84801238, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Function and regulation of nuclear factor 1 X-type on chondrocyte proliferation and differentiation.
Title: Function and regulation of nuclear factor 1 X-type on chondrocyte proliferation and differentiation.
Hydrocephalus in Nfix(-/-) Mice Is Underpinned by Changes in Ependymal Cell Physiology.
Title: Hydrocephalus in Nfix(-/-) Mice Is Underpinned by Changes in Ependymal Cell Physiology.
Deletion of NFIX results in defective progression through meiosis within the mouse testisdagger.
Title: Deletion of NFIX results in defective progression through meiosis within the mouse testis†.
Selective ablation of Nfix in macrophages attenuates muscular dystrophy by inhibiting fibro-adipogenic progenitor-dependent fibrosis.
Title: Selective ablation of Nfix in macrophages attenuates muscular dystrophy by inhibiting fibro-adipogenic progenitor-dependent fibrosis.
High-mobility group AT-Hook 1 mediates the role of nuclear factor I/X in osteogenic differentiation through activating canonical Wnt signaling.
Title: High-mobility group AT-Hook 1 mediates the role of nuclear factor I/X in osteogenic differentiation through activating canonical Wnt signaling.
Temporarily Epigenetic Repression in Bergmann Glia Regulates the Migration of Granule Cells.
Title: Temporarily Epigenetic Repression in Bergmann Glia Regulates the Migration of Granule Cells.
The Transcription Factor Nfix Requires RhoA-ROCK1 Dependent Phagocytosis to Mediate Macrophage Skewing during Skeletal Muscle Regeneration.
Title: The Transcription Factor Nfix Requires RhoA-ROCK1 Dependent Phagocytosis to Mediate Macrophage Skewing during Skeletal Muscle Regeneration.
MicroRNA-25-3p regulates osteoclasts through nuclear factor I X.
Title: MicroRNA-25-3p regulates osteoclasts through nuclear factor I X.
Removal of Nfix gene from either neural stem and progenitor cells, or neuroblasts, within the ventricular-subventricular zone culminated in neuroblast migration defects. Mechanistically, we identified aberrant neuroblast branching, due in part to increased expression of the guanylyl cyclase natriuretic peptide receptor 2 (Npr2), as a factor contributing to abnormal migration in Nfix-deficient adult mice.
Title: NFIX-Mediated Inhibition of Neuroblast Branching Regulates Migration Within the Adult Mouse Ventricular-Subventricular Zone.
The NFI transcription factors (Nfia, Nfib, and Nfix) are selectively expressed in late retinal progenitor cells and they control bipolar interneuron and Muller glia cell fate specification and promote proliferative quiescence.
Title: Single-Cell RNA-Seq Analysis of Retinal Development Identifies NFI Factors as Regulating Mitotic Exit and Late-Born Cell Specification.

Submit: New GeneRIF Correction See all GeneRIFs (38)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (8) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NFIX (e-PCR)
- UniSTS:504112

AU048500 (e-PCR)
- UniSTS:144950

UniSTS:474756 (e-PCR)
- UniSTS:474756

Nfix (e-PCR), detects polymorphism
- UniSTS:474756

M-10555 (e-PCR)
- UniSTS:186283

NoName (e-PCR)
- UniSTS:235948

Nfix (e-PCR), detects polymorphism
- UniSTS:507089

Nfix (e-PCR), detects polymorphism
- UniSTS:532434

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Rho protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within astrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in astrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in atrioventricular canal morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within brain morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in camera-type eye development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell proliferation in forebrain	IDA Inferred from Direct Assay more info	PubMed
involved_in cell proliferation in forebrain	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell quiescence	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell quiescence	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to BMP stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebellar Purkinje cell layer development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebellar cortex morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebellar granule cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cerebellar granule cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebellum development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cerebral cortex development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within collateral sprouting	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ear development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endochondral ossification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelium development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within exit from mitosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within forebrain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in forebrain radial glial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within generation of neurons	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in glial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glial cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gliogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in gliogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hippocampus development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in homeostasis of number of cells within a tissue	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lateral ventricle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lateral ventricle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in learning	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within macrophage differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuroblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory bulb development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within osteoclast differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within osteoclast proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to wounding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to wounding	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in skeletal muscle satellite cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in skeletal muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in skeletal muscle tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within social behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spinal cord development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within stem cell population maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tissue homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: nuclear factor 1 X-type

Names: CCAAT-box-binding transcription factor; TGGCA-binding protein; nuclear factor 1/X

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081981.3 → NP_001075450.1 nuclear factor 1 X-type isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) encodes isoform 3.

Source sequence(s)

AC145556, AC155163

Consensus CDS

CCDS40411.1

UniProtKB/TrEMBL

E9PUH7, Q5CZY4

Related

ENSMUSP00000105386.2, ENSMUST00000109764.8

Conserved Domains (3) summary

pfam00859
Location:205 → 494

CTF_NFI; CTF/NF-I family transcription modulation region

pfam10524
Location:2 → 38

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

cl00055
Location:60 → 162

MH1; N-terminal Mad Homology 1 (MH1) domain
NM_001081982.3 → NP_001075451.1 nuclear factor 1 X-type isoform 1

See identical proteins and their annotated locations for NP_001075451.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 5' UTR, initiates translation at an alternate start codon, and has multiple coding region differences, compared to variant 3. The encoded isoform (1) has a distinct N-terminus and is shorter than isoform 3.

Source sequence(s)

AC145556, AC155163

Consensus CDS

CCDS40413.1

UniProtKB/Swiss-Prot

O08519, P70257, P70258, Q64192, Q99L78, Q9R1G2

UniProtKB/TrEMBL

D3YZ00

Related

ENSMUSP00000096669.4, ENSMUST00000099070.10

Conserved Domains (3) summary

pfam00859
Location:213 → 418

CTF_NFI; CTF/NF-I family transcription modulation region

pfam10524
Location:9 → 46

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

cl00055
Location:68 → 170

MH1; N-terminal Mad Homology 1 (MH1) domain
NM_001297601.2 → NP_001284530.1 nuclear factor 1 X-type isoform 4

See identical proteins and their annotated locations for NP_001284530.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an alternate in-frame exon and another alternate exon compared to variant 3, that causes a frameshift. The resulting isoform (4) has a shorter and distinct C-terminus and lacks an alternate internal segment compared to isoform 3.

Source sequence(s)

AC145556, AC155163

Consensus CDS

CCDS80907.1

UniProtKB/TrEMBL

Q3TYK3

Related

ENSMUSP00000105384.2, ENSMUST00000109762.8

Conserved Domains (3) summary

pfam00859
Location:205 → 368

CTF_NFI; CTF/NF-I family transcription modulation region

pfam10524
Location:2 → 38

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

cl00055
Location:60 → 162

MH1; N-terminal Mad Homology 1 (MH1) domain
NM_001371052.1 → NP_001357981.1 nuclear factor 1 X-type isoform 5

Status: VALIDATED

Description

Transcript Variant: This variant (5) encodes the longest isoform (5).

Source sequence(s)

AC145556, AC155163

UniProtKB/TrEMBL

Q5CZY4

Conserved Domains (3) summary

pfam00859
Location:216 → 505

CTF_NFI; CTF/NF-I family transcription modulation region

pfam10524
Location:13 → 49

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

cl00055
Location:71 → 173

MH1; N-terminal Mad Homology 1 (MH1) domain
NM_001371053.1 → NP_001357982.1 nuclear factor 1 X-type isoform 6

Status: VALIDATED

Source sequence(s)

AC145556, AC155163

UniProtKB/TrEMBL

D3YZ00

Conserved Domains (3) summary

pfam10524
Location:9 → 46

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

pfam00859
Location:213 → 502

CTF_NFI; CTF/NF-I family transcription modulation region

cl00055
Location:68 → 170

MH1; N-terminal Mad Homology 1 (MH1) domain
NM_001371054.1 → NP_001357983.1 nuclear factor 1 X-type isoform 7

Status: VALIDATED

Source sequence(s)

AC145556, AC155163

UniProtKB/TrEMBL

Q5CZY4

Conserved Domains (3) summary

pfam10524
Location:6 → 42

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

pfam00859
Location:209 → 498

CTF_NFI; CTF/NF-I family transcription modulation region

cl00055
Location:64 → 166

MH1; N-terminal Mad Homology 1 (MH1) domain
NM_001371055.1 → NP_001357984.1 nuclear factor 1 X-type isoform 8

Status: VALIDATED

Source sequence(s)

AC145556, AC155163

UniProtKB/TrEMBL

Q5CZY4

Conserved Domains (3) summary

pfam00859
Location:205 → 453

CTF_NFI; CTF/NF-I family transcription modulation region

pfam10524
Location:2 → 38

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

cl00055
Location:60 → 162

MH1; N-terminal Mad Homology 1 (MH1) domain
NM_001371056.1 → NP_001357985.1 nuclear factor 1 X-type isoform 9

Status: VALIDATED

Source sequence(s)

AC145556, AC155163

UniProtKB/Swiss-Prot

O08519, P70257, P70258, Q64192, Q99L78, Q9R1G2

UniProtKB/TrEMBL

D3YZ00

Conserved Domains (3) summary

pfam00859
Location:216 → 421

CTF_NFI; CTF/NF-I family transcription modulation region

pfam10524
Location:9 → 49

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

cl00055
Location:71 → 173

MH1; N-terminal Mad Homology 1 (MH1) domain
NM_001371057.1 → NP_001357986.1 nuclear factor 1 X-type isoform 10

Status: VALIDATED

Source sequence(s)

AC145556, AC155163

UniProtKB/Swiss-Prot

O08519, P70257, P70258, Q64192, Q99L78, Q9R1G2

UniProtKB/TrEMBL

D3YZ00

Conserved Domains (3) summary

pfam00859
Location:205 → 410

CTF_NFI; CTF/NF-I family transcription modulation region

pfam10524
Location:2 → 38

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

cl00055
Location:60 → 162

MH1; N-terminal Mad Homology 1 (MH1) domain
NM_001371058.1 → NP_001357987.1 nuclear factor 1 X-type isoform 11

Status: VALIDATED

Source sequence(s)

AC145556, AC155163

UniProtKB/Swiss-Prot

O08519, P70257, P70258, Q64192, Q99L78, Q9R1G2

UniProtKB/TrEMBL

D3YZ00

Conserved Domains (3) summary

pfam00859
Location:205 → 409

CTF_NFI; CTF/NF-I family transcription modulation region

pfam10524
Location:2 → 38

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

cl00055
Location:60 → 162

MH1; N-terminal Mad Homology 1 (MH1) domain
NM_001371059.1 → NP_001357988.1 nuclear factor 1 X-type isoform 12

Status: VALIDATED

Source sequence(s)

AC145556, AC155163

UniProtKB/Swiss-Prot

O08519, P70257, P70258, Q64192, Q99L78, Q9R1G2

UniProtKB/TrEMBL

D3YZ00

Conserved Domains (3) summary

pfam00859
Location:209 → 414

CTF_NFI; CTF/NF-I family transcription modulation region

pfam10524
Location:6 → 42

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

cl00055
Location:64 → 166

MH1; N-terminal Mad Homology 1 (MH1) domain
NM_001371060.1 → NP_001357989.1 nuclear factor 1 X-type isoform 13

Status: VALIDATED

Source sequence(s)

AC145556, AC155163

Conserved Domains (2) summary

pfam00859
Location:166 → 370

CTF_NFI; CTF/NF-I family transcription modulation region

cl00055
Location:21 → 123

MH1; N-terminal Mad Homology 1 (MH1) domain
NM_001371061.1 → NP_001357990.1 nuclear factor 1 X-type isoform 14

Status: VALIDATED

Source sequence(s)

AC145556, AC155163

Conserved Domains (3) summary

pfam00859
Location:205 → 382

CTF_NFI; CTF/NF-I family transcription modulation region

pfam10524
Location:2 → 38

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

cl00055
Location:60 → 162

MH1; N-terminal Mad Homology 1 (MH1) domain
NM_001371062.1 → NP_001357991.1 nuclear factor 1 X-type isoform 15

Status: VALIDATED

Description

Transcript Variant: This variant (15), as well as variant 16, encodes isoform 15.

Source sequence(s)

AC145556, AC155163

Conserved Domains (2) summary

pfam00859
Location:166 → 371

CTF_NFI; CTF/NF-I family transcription modulation region

cl00055
Location:21 → 123

MH1; N-terminal Mad Homology 1 (MH1) domain
NM_001371063.1 → NP_001357992.1 nuclear factor 1 X-type isoform 15

Status: VALIDATED

Description

Transcript Variant: This variant (16), as well as variant 15, encodes isoform 15.

Source sequence(s)

AC145556, AC155163

Conserved Domains (2) summary

pfam00859
Location:166 → 371

CTF_NFI; CTF/NF-I family transcription modulation region

cl00055
Location:21 → 123

MH1; N-terminal Mad Homology 1 (MH1) domain
NM_010906.4 → NP_035036.1 nuclear factor 1 X-type isoform 2

See identical proteins and their annotated locations for NP_035036.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, initiates translation at an alternate start codon, and has multiple coding region differences, compared to variant 3. The encoded isoform (1) has a distinct N-terminus and is shorter than isoform 3.

Source sequence(s)

AC145556, AC155163

Consensus CDS

CCDS40412.1

UniProtKB/Swiss-Prot

P70257

UniProtKB/TrEMBL

Q3TYK3, Q5CZY4

Related

ENSMUSP00000076005.7, ENSMUST00000076715.13

Conserved Domains (3) summary

pfam00859
Location:213 → 390

CTF_NFI; CTF/NF-I family transcription modulation region

pfam10524
Location:9 → 46

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

cl00055
Location:68 → 170

MH1; N-terminal Mad Homology 1 (MH1) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

85431341..85527086 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153804.1 → XP_036009697.1 nuclear factor 1 X-type isoform X15

UniProtKB/Swiss-Prot

O08519, P70257, P70258, Q64192, Q99L78, Q9R1G2

UniProtKB/TrEMBL

D3YZ00

Conserved Domains (3) summary

pfam10524
Location:9 → 46

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

pfam00859
Location:213 → 418

CTF_NFI; CTF/NF-I family transcription modulation region

cl00055
Location:68 → 170

MH1; N-terminal Mad Homology 1 (MH1) domain
XM_036153796.1 → XP_036009689.1 nuclear factor 1 X-type isoform X5

Conserved Domains (2) summary

pfam00859
Location:166 → 371

CTF_NFI; CTF/NF-I family transcription modulation region

cl00055
Location:21 → 123

MH1; N-terminal Mad Homology 1 (MH1) domain
XM_036153797.1 → XP_036009690.1 nuclear factor 1 X-type isoform X6

Conserved Domains (2) summary

pfam00859
Location:166 → 370

CTF_NFI; CTF/NF-I family transcription modulation region

cl00055
Location:21 → 123

MH1; N-terminal Mad Homology 1 (MH1) domain
XM_036153805.1 → XP_036009698.1 nuclear factor 1 X-type isoform X16

UniProtKB/Swiss-Prot

O08519, P70257, P70258, Q64192, Q99L78, Q9R1G2

UniProtKB/TrEMBL

D3YZ00

Conserved Domains (3) summary

pfam10524
Location:2 → 38

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

pfam00859
Location:205 → 410

CTF_NFI; CTF/NF-I family transcription modulation region

cl00055
Location:60 → 162

MH1; N-terminal Mad Homology 1 (MH1) domain
XM_036153799.1 → XP_036009692.1 nuclear factor 1 X-type isoform X10

UniProtKB/TrEMBL

Q5CZY4

Conserved Domains (3) summary

pfam10524
Location:6 → 42

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

pfam00859
Location:209 → 498

CTF_NFI; CTF/NF-I family transcription modulation region

cl00055
Location:64 → 166

MH1; N-terminal Mad Homology 1 (MH1) domain
XM_036153802.1 → XP_036009695.1 nuclear factor 1 X-type isoform X13

UniProtKB/Swiss-Prot

O08519, P70257, P70258, Q64192, Q99L78, Q9R1G2

UniProtKB/TrEMBL

D3YZ00

Conserved Domains (3) summary

pfam10524
Location:9 → 46

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

pfam00859
Location:213 → 417

CTF_NFI; CTF/NF-I family transcription modulation region

cl00055
Location:68 → 170

MH1; N-terminal Mad Homology 1 (MH1) domain
XM_036153809.1 → XP_036009702.1 nuclear factor 1 X-type isoform X19

Conserved Domains (2) summary

pfam00859
Location:166 → 370

CTF_NFI; CTF/NF-I family transcription modulation region

cl00055
Location:21 → 123

MH1; N-terminal Mad Homology 1 (MH1) domain
XM_036153807.1 → XP_036009700.1 nuclear factor 1 X-type isoform X18

Conserved Domains (2) summary

pfam00859
Location:166 → 371

CTF_NFI; CTF/NF-I family transcription modulation region

cl00055
Location:21 → 123

MH1; N-terminal Mad Homology 1 (MH1) domain
XM_036153808.1 → XP_036009701.1 nuclear factor 1 X-type isoform X18

Conserved Domains (2) summary

pfam00859
Location:166 → 371

CTF_NFI; CTF/NF-I family transcription modulation region

cl00055
Location:21 → 123

MH1; N-terminal Mad Homology 1 (MH1) domain
XM_036153803.1 → XP_036009696.1 nuclear factor 1 X-type isoform X14

UniProtKB/Swiss-Prot

O08519, P70257, P70258, Q64192, Q99L78, Q9R1G2

UniProtKB/TrEMBL

D3YZ00

Conserved Domains (3) summary

pfam10524
Location:6 → 42

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

pfam00859
Location:209 → 413

CTF_NFI; CTF/NF-I family transcription modulation region

cl00055
Location:64 → 166

MH1; N-terminal Mad Homology 1 (MH1) domain
XM_036153798.1 → XP_036009691.1 nuclear factor 1 X-type isoform X9

UniProtKB/TrEMBL

D3YZ00

Related

ENSMUSP00000115691.2, ENSMUST00000126806.2

Conserved Domains (3) summary

pfam10524
Location:9 → 46

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

pfam00859
Location:213 → 501

CTF_NFI; CTF/NF-I family transcription modulation region

cl00055
Location:68 → 170

MH1; N-terminal Mad Homology 1 (MH1) domain
XM_030243342.2 → XP_030099202.1 nuclear factor 1 X-type isoform X1

UniProtKB/TrEMBL

Q5CZY4

Conserved Domains (2) summary

pfam00859
Location:166 → 455

CTF_NFI; CTF/NF-I family transcription modulation region

cl00055
Location:21 → 123

MH1; N-terminal Mad Homology 1 (MH1) domain
XM_006530755.5 → XP_006530818.2 nuclear factor 1 X-type isoform X1

UniProtKB/TrEMBL

Q5CZY4

Conserved Domains (2) summary

pfam00859
Location:166 → 455

CTF_NFI; CTF/NF-I family transcription modulation region

cl00055
Location:21 → 123

MH1; N-terminal Mad Homology 1 (MH1) domain
XM_011248326.4 → XP_011246628.2 nuclear factor 1 X-type isoform X8

Conserved Domains (2) summary

pfam00859
Location:166 → 329

CTF_NFI; CTF/NF-I family transcription modulation region

cl00055
Location:21 → 123

MH1; N-terminal Mad Homology 1 (MH1) domain
XM_006530758.5 → XP_006530821.2 nuclear factor 1 X-type isoform X4

UniProtKB/TrEMBL

Q5CZY4

Conserved Domains (2) summary

pfam00859
Location:166 → 413

CTF_NFI; CTF/NF-I family transcription modulation region

cl00055
Location:21 → 123

MH1; N-terminal Mad Homology 1 (MH1) domain
XM_006530756.5 → XP_006530819.2 nuclear factor 1 X-type isoform X2

UniProtKB/TrEMBL

Q5CZY4

Conserved Domains (2) summary

pfam00859
Location:166 → 454

CTF_NFI; CTF/NF-I family transcription modulation region

cl00055
Location:21 → 123

MH1; N-terminal Mad Homology 1 (MH1) domain
XM_006530760.5 → XP_006530823.2 nuclear factor 1 X-type isoform X7

Conserved Domains (2) summary

pfam00859
Location:166 → 330

CTF_NFI; CTF/NF-I family transcription modulation region

cl00055
Location:21 → 123

MH1; N-terminal Mad Homology 1 (MH1) domain
XM_006530757.5 → XP_006530820.2 nuclear factor 1 X-type isoform X3

UniProtKB/TrEMBL

Q5CZY4

Conserved Domains (2) summary

pfam00859
Location:166 → 414

CTF_NFI; CTF/NF-I family transcription modulation region

cl00055
Location:21 → 123

MH1; N-terminal Mad Homology 1 (MH1) domain
XM_030243347.2 → XP_030099207.1 nuclear factor 1 X-type isoform X1

UniProtKB/TrEMBL

Q5CZY4

Conserved Domains (2) summary

pfam00859
Location:166 → 455

CTF_NFI; CTF/NF-I family transcription modulation region

cl00055
Location:21 → 123

MH1; N-terminal Mad Homology 1 (MH1) domain
XM_030243345.2 → XP_030099205.1 nuclear factor 1 X-type isoform X1

UniProtKB/TrEMBL

Q5CZY4

Conserved Domains (2) summary

pfam00859
Location:166 → 455

CTF_NFI; CTF/NF-I family transcription modulation region

cl00055
Location:21 → 123

MH1; N-terminal Mad Homology 1 (MH1) domain
XM_036153801.1 → XP_036009694.1 nuclear factor 1 X-type isoform X2

UniProtKB/TrEMBL

Q5CZY4

Conserved Domains (2) summary

pfam00859
Location:166 → 454

CTF_NFI; CTF/NF-I family transcription modulation region

cl00055
Location:21 → 123

MH1; N-terminal Mad Homology 1 (MH1) domain
XM_030243343.2 → XP_030099203.1 nuclear factor 1 X-type isoform X1

UniProtKB/TrEMBL

Q5CZY4

Conserved Domains (2) summary

pfam00859
Location:166 → 455

CTF_NFI; CTF/NF-I family transcription modulation region

cl00055
Location:21 → 123

MH1; N-terminal Mad Homology 1 (MH1) domain
XM_036153800.1 → XP_036009693.1 nuclear factor 1 X-type isoform X12

UniProtKB/TrEMBL

Q5CZY4

Conserved Domains (3) summary

pfam10524
Location:2 → 38

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

pfam00859
Location:205 → 493

CTF_NFI; CTF/NF-I family transcription modulation region

cl00055
Location:60 → 162

MH1; N-terminal Mad Homology 1 (MH1) domain
XM_030243341.2 → XP_030099201.1 nuclear factor 1 X-type isoform X11

UniProtKB/TrEMBL

Q5CZY4

Conserved Domains (3) summary

pfam00859
Location:209 → 497

CTF_NFI; CTF/NF-I family transcription modulation region

pfam10524
Location:6 → 42

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

cl00055
Location:64 → 166

MH1; N-terminal Mad Homology 1 (MH1) domain
XM_036153806.1 → XP_036009699.1 nuclear factor 1 X-type isoform X17

Conserved Domains (3) summary

pfam10524
Location:9 → 49

NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

pfam00859
Location:216 → 380

CTF_NFI; CTF/NF-I family transcription modulation region

cl00055
Location:71 → 173

MH1; N-terminal Mad Homology 1 (MH1) domain