Gpr157 G protein-coupled receptor 157 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gpr157provided by RGD
Official Full Name: G protein-coupled receptor 157provided by RGD
Primary source: RGD:1311096
See related: EnsemblRapid:ENSRNOG00000017528 AllianceGenome:RGD:1311096
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway; circadian behavior; and radial glial cell differentiation. Predicted to be located in ciliary membrane. Predicted to be active in plasma membrane. Orthologous to human GPR157 (G protein-coupled receptor 157). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 55.8), Heart (RPKM 51.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (165833651..165849376)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (160550703..160566432)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (167109691..167125380)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in circadian behavior	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in radial glial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in radial glial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in ciliary membrane	ISO Inferred from Sequence Orthology more info
located_in ciliary membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: G-protein coupled receptor 157

Names: probable G-protein coupled receptor 157

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012107.1 → NP_001012107.1 G-protein coupled receptor 157

See identical proteins and their annotated locations for NP_001012107.1

Status: PROVISIONAL

Source sequence(s)

BC090013

UniProtKB/Swiss-Prot

Q5FVG1

UniProtKB/TrEMBL

A6IUC6

Related

ENSRNOP00000052398.1, ENSRNOT00000055536.3

Conserved Domains (1) summary

cl21561
Location:92 → 163

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

165833651..165849376

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039110103.1 → XP_038966031.1 G-protein coupled receptor 157 isoform X1

Conserved Domains (2) summary

cd14964
Location:80 → 104

7tm_GPCRs; TM helix 3 [structural motif]

cl28897
Location:62 → 159

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily