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    supt16h.S SPT16 homolog, facilitates chromatin remodeling subunit S homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 399345, updated on 4-Nov-2024

    Summary

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    Official Symbol
    supt16h.S
    Official Full Name
    SPT16 homolog, facilitates chromatin remodeling subunit S homeolog
    Primary source
    Xenbase:XB-GENE-979310
    Locus tag
    XELAEV_18010282mg
    See related
    EnsemblRapid:ENSXLAG00005012577 AllianceGenome:Xenbase:XB-GENE-979310
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    supt16h
    Summary
    Predicted to enable nucleosome binding activity. Predicted to act upstream of or within DNA repair; DNA replication; and transcription elongation by RNA polymerase II. Predicted to be located in chromosome and nucleus. Predicted to be part of FACT complex. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with dysmorphic facies and thin corpus callosum. Orthologous to human SUPT16H (SPT16 homolog, facilitates chromatin remodeling subunit). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See supt16h.S in Genome Data Viewer
    Location:
    chromosome: 1S
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1S NC_054372.1 (131264468..131303307)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1S NC_030725.1 (116064229..116103076)

    Chromosome 1S - NC_054372.1Genomic Context describing neighboring genes Neighboring gene chromodomain helicase DNA binding protein 8 S homeolog Neighboring gene small nucleolar RNA U6-53/MBII-28 Neighboring gene protein kinase C delta type-like Neighboring gene RPGR interacting protein 1 S homeolog Neighboring gene platelet glycoprotein VI

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Incorporation of DUF/FACT into chromatin enhances the accessibility of nucleosomal DNA. Seo H, et al. Biochem Biophys Res Commun, 2003 Mar 28. PMID 12646158
    2. A DNA unwinding factor involved in DNA replication in cell-free extracts of Xenopus eggs. Okuhara K, et al. Curr Biol, 1999 Apr 8. PMID 10209116
    3. p97 ATPase, an ATPase involved in membrane fusion, interacts with DNA unwinding factor (DUF) that functions in DNA replication. Yamada T, et al. FEBS Lett, 2000 Jan 28. PMID 10682845
    4. Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation. Nishiyama A, et al. Nat Commun, 2020 Mar 6. PMID 32144273, Free PMC Article
    5. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables nucleosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within transcription elongation by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of FACT complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    FACT complex subunit SPT16
    Names
    DNA unwinding factor 140 kDa subunit
    DUF140
    facilitates chromatin transcription complex subunit spt16
    suppressor of Ty 16 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001090697.1 → NP_001084166.1  FACT complex subunit SPT16

      See identical proteins and their annotated locations for NP_001084166.1

      Status: PROVISIONAL

      Source sequence(s)
      AB004794
      UniProtKB/Swiss-Prot
      Q6GQJ6, Q9W603
      UniProtKB/TrEMBL
      A0A974DTX5, B7ZQW8
      Related
      ENSXLAP00005037021.1, ENSXLAT00005037930.1
      Conserved Domains (5) summary
      COG5406
      Location:5 → 1006
      COG5406; Nucleosome binding factor SPN, SPT16 subunit [Transcription, Replication, recombination and repair, Chromatin structure and dynamics]
      cd01091
      Location:181 → 421
      CDC68-like; Related to aminopeptidase P and aminopeptidase M, a member of this domain family is present in cell division control protein 68, a transcription factor.
      pfam08512
      Location:816 → 892
      Rtt106; Histone chaperone Rttp106-like
      pfam08644
      Location:537 → 692
      SPT16; FACT complex subunit (SPT16/CDC68)
      pfam14826
      Location:5 → 167
      FACT-Spt16_Nlob; FACT complex subunit SPT16 N-terminal lobe domain

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054372.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      131264468..131303307
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W603.2 GenPept UniProtKB/Swiss-Prot:Q9W603

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