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    Slc25a40 solute carrier family 25, member 40 [ Mus musculus (house mouse) ]

    Gene ID: 319653, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Slc25a40provided by MGI
    Official Full Name
    solute carrier family 25, member 40provided by MGI
    Primary source
    MGI:MGI:2442486
    See related
    Ensembl:ENSMUSG00000054099 AllianceGenome:MGI:2442486
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    B230315F11Rik
    Summary
    Predicted to enable glutathione transmembrane transporter activity. Involved in erythrocyte development. Located in mitochondrion. Orthologous to human SLC25A40 (solute carrier family 25 member 40). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 5.3), CNS E18 (RPKM 3.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc25a40 in Genome Data Viewer
    Location:
    5 A1; 5 3.43 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (8472730..8504840)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (8422730..8454839)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene a disintegrin and metallopeptidase domain 22 Neighboring gene STARR-seq mESC enhancer starr_12382 Neighboring gene predicted gene, 23993 Neighboring gene STARR-seq mESC enhancer starr_12383 Neighboring gene STARR-seq mESC enhancer starr_12384 Neighboring gene ribosomal protein L19 pseudogene Neighboring gene STARR-seq mESC enhancer starr_12387 Neighboring gene DBF4 zinc finger Neighboring gene STARR-positive B cell enhancer mm9_chr5:8489752-8490052 Neighboring gene STARR-seq mESC enhancer starr_12390 Neighboring gene RUN domain containing 3B Neighboring gene ATP-binding cassette, sub-family B member 1A Neighboring gene predicted gene, 31157

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells. Wang Y, et al. Nature, 2021 Nov. PMID 34707288, Free PMC Article
    2. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables glutathione transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutathione transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in erythrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glutathione transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in import into the mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial glutathione transporter SLC25A40; probable mitochondrial glutathione transporter SLC25A40

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289595.1 → NP_001276524.1  mitochondrial glutathione transporter SLC25A40 isoform a

      See identical proteins and their annotated locations for NP_001276524.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AK044260, AK079538, AK084797, BY368313
      Consensus CDS
      CCDS39010.1
      UniProtKB/Swiss-Prot
      Q3UVZ5, Q8BGP6, Q8BXT8
      Related
      ENSMUSP00000130630.2, ENSMUST00000170496.6
      Conserved Domains (1) summary
      pfam00153
      Location:14 → 135
      Mito_carr; Mitochondrial carrier protein

    2. NM_001289596.1 → NP_001276525.1  mitochondrial glutathione transporter SLC25A40 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus than isoform a.
      Source sequence(s)
      AK044260, AK079538, BY368313
      UniProtKB/Swiss-Prot
      Q8BGP6
      Conserved Domains (1) summary
      pfam00153
      Location:171 → 268
      Mito_carr; Mitochondrial carrier protein

    3. NM_178766.5 → NP_848881.2  mitochondrial glutathione transporter SLC25A40 isoform a

      See identical proteins and their annotated locations for NP_848881.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 encode the same isoform (a).
      Source sequence(s)
      AK044260, AK045863, AK079538, BY368313
      Consensus CDS
      CCDS39010.1
      UniProtKB/Swiss-Prot
      Q3UVZ5, Q8BGP6, Q8BXT8
      Related
      ENSMUSP00000067611.4, ENSMUST00000066921.10
      Conserved Domains (1) summary
      pfam00153
      Location:14 → 135
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      8472730..8504840
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503592.5 → XP_006503655.3  probable mitochondrial glutathione transporter SLC25A40 isoform X2

      Conserved Domains (1) summary
      pfam00153
      Location:86 → 207
      Mito_carr; Mitochondrial carrier protein

    2. XM_006503591.5 → XP_006503654.1  probable mitochondrial glutathione transporter SLC25A40 isoform X1

      See identical proteins and their annotated locations for XP_006503654.1

      UniProtKB/Swiss-Prot
      Q3UVZ5, Q8BGP6, Q8BXT8
      Conserved Domains (1) summary
      pfam00153
      Location:14 → 135
      Mito_carr; Mitochondrial carrier protein

    3. XM_030254570.2 → XP_030110430.1  probable mitochondrial glutathione transporter SLC25A40 isoform X5

      Conserved Domains (1) summary
      pfam00153
      Location:14 → 135
      Mito_carr; Mitochondrial carrier protein

    4. XM_030254569.2 → XP_030110429.1  probable mitochondrial glutathione transporter SLC25A40 isoform X4

      Conserved Domains (1) summary
      pfam00153
      Location:171 → 268
      Mito_carr; Mitochondrial carrier protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGP6.1 GenPept UniProtKB/Swiss-Prot:Q8BGP6

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