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    Slc26a9 solute carrier family 26, member 9 [ Mus musculus (house mouse) ]

    Gene ID: 320718, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Slc26a9provided by MGI
    Official Full Name
    solute carrier family 26, member 9provided by MGI
    Primary source
    MGI:MGI:2444594
    See related
    Ensembl:ENSMUSG00000042268 AllianceGenome:MGI:2444594
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E030002L01Rik
    Summary
    Enables chloride channel activity; chloride:bicarbonate antiporter activity; and identical protein binding activity. Involved in monoatomic anion transport. Acts upstream of or within bicarbonate transport; chloride transport; and regulation of pH. Located in apical plasma membrane. Is expressed in several structures, including adrenal gland; nervous system; respiratory system; and sensory organ. Orthologous to human SLC26A9 (solute carrier family 26 member 9). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in stomach adult (RPKM 21.9) and lung adult (RPKM 13.8) See more
    Orthologs
    human all
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    Genomic context

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    See Slc26a9 in Genome Data Viewer
    Location:
    1 E4; 1 57.18 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (131671760..131699242)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (131744022..131771504)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RAB7B, member RAS oncogene family Neighboring gene predicted gene, 30104 Neighboring gene STARR-seq mESC enhancer starr_02224 Neighboring gene peptidase M20 domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_02225 Neighboring gene STARR-positive B cell enhancer ABC_E8960 Neighboring gene solute carrier family 41, member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Hydrokinetic pancreatic function and insulin secretion are moduled by Cl(-) uniporter Slc26a9 in mice. Li T, et al. Acta Physiol (Oxf), 2022 Jan. PMID 34525257
    2. Deletion of the chloride transporter Slc26a9 causes loss of tubulovesicles in parietal cells and impairs acid secretion in the stomach. Xu J, et al. Proc Natl Acad Sci U S A, 2008 Nov 18. PMID 19004773, Free PMC Article
    3. Slc26a9--anion exchanger, channel and Na+ transporter. Chang MH, et al. J Membr Biol, 2009 Apr. PMID 19365592, Free PMC Article
    4. Damage to the gastric epithelium activates cellular bicarbonate secretion via SLC26A9 Cl(-)/HCO(3)(-). Demitrack ES, et al. Am J Physiol Gastrointest Liver Physiol, 2010 Jul. PMID 20413716, Free PMC Article
    5. Cryo-EM structures and functional characterization of murine Slc26a9 reveal mechanism of uncoupled chloride transport. Walter JD, et al. Elife, 2019 Jul 24. PMID 31339488, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SLC26A9 deficiency causes gastric intraepithelial neoplasia in mice and aggressive gastric cancer in humans.
      Title: SLC26A9 deficiency causes gastric intraepithelial neoplasia in mice and aggressive gastric cancer in humans.
    2. Hydrokinetic pancreatic function and insulin secretion are moduled by Cl(-) uniporter Slc26a9 in mice.
      Title: Hydrokinetic pancreatic function and insulin secretion are moduled by Cl(-) uniporter Slc26a9 in mice.
    3. conformational transitions of Slc26a9, supporting a rapid alternate-access mechanism which mediates uncoupled chloride transport with negligible bicarbonate or sulfate permeability, is reported.
      Title: Cryo-EM structures and functional characterization of murine Slc26a9 reveal mechanism of uncoupled chloride transport.
    4. The chloride channel/transporter Slc26a9 regulates the systemic arterial pressure and renal chloride excretion.
      Title: The chloride channel/transporter Slc26a9 regulates the systemic arterial pressure and renal chloride excretion.
    5. SLC26A9 is activated in airway inflammation. Slc26a9-deficient mice exhibited IL-13-induced airway mucus obstruction. SLC26A9-mediated Cl- secretion is essential for preventing airway obstruction in allergic airway disease.
      Title: SLC26A9-mediated chloride secretion prevents mucus obstruction in airway inflammation.
    6. Cellular HCO(3)(-) secretion, likely through SLC26A9, is the dominant mechanism whereby gastric mucosal surface pH transiently increases in response to photodamage.
      Title: Damage to the gastric epithelium activates cellular bicarbonate secretion via SLC26A9 Cl(-)/HCO(3)(-).
    7. Slc26a9 has three discrete physiological modes: nCl(-)-HCO(3)(-) exchanger, Cl(-) channel, and Na(+)-anion cotransporter.
      Title: Slc26a9--anion exchanger, channel and Na+ transporter.
    8. Slc26a9 plays an essential role in gastric acid secretion via effects on the viability of tubulovesicles/secretory canaliculi and by regulating chloride secretion in parietal cells.
      Title: Deletion of the chloride transporter Slc26a9 causes loss of tubulovesicles in parietal cells and impairs acid secretion in the stomach.
    9. Slc26a9 functions as an electrogenic nCl-/HCO3- exchanger, suggesting a role in pulmonary and gastric HCO3- secretion and/or CO2 transport.
      Title: Physiology of electrogenic SLC26 paralogues.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables bicarbonate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables bicarbonate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chloride channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chloride channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chloride transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chloride:bicarbonate antiporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables oxalate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables solute:inorganic anion antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sulfate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within bicarbonate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chloride transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within chloride transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chloride transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monoatomic anion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic anion transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of pH IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sulfate transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier family 26 member 9
    Names
    SLC26A9 anion transporter/exchanger
    anion transporter/exchanger protein 9
    anion transporter/exchanger-9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177243.4 → NP_796217.2  solute carrier family 26 member 9

      See identical proteins and their annotated locations for NP_796217.2

      Status: VALIDATED

      Source sequence(s)
      AK078966, AK086815
      Consensus CDS
      CCDS15273.1
      UniProtKB/Swiss-Prot
      Q8BU91, Q8BVC3
      UniProtKB/TrEMBL
      A0A0R4J0F7
      Related
      ENSMUSP00000036916.4, ENSMUST00000049027.10
      Conserved Domains (1) summary
      TIGR00815
      Location:57 → 733
      sulP; high affinity sulphate transporter 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      131671760..131699242
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529700.2 → XP_006529763.1  solute carrier family 26 member 9 isoform X1

      See identical proteins and their annotated locations for XP_006529763.1

      UniProtKB/Swiss-Prot
      Q8BU91, Q8BVC3
      UniProtKB/TrEMBL
      A0A0R4J0F7
      Conserved Domains (1) summary
      TIGR00815
      Location:57 → 733
      sulP; high affinity sulphate transporter 1

    2. XM_030254980.1 → XP_030110840.1  solute carrier family 26 member 9 isoform X2

      Conserved Domains (1) summary
      TIGR00815
      Location:7 → 457
      sulP; high affinity sulphate transporter 1

    3. XM_006529701.1 → XP_006529764.1  solute carrier family 26 member 9 isoform X2

      Conserved Domains (1) summary
      TIGR00815
      Location:7 → 457
      sulP; high affinity sulphate transporter 1

    RNA

    1. XR_387176.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BU91.1 GenPept UniProtKB/Swiss-Prot:Q8BU91

    Gene LinkOut

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