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    Zfp27 zinc finger protein 27 [ Mus musculus (house mouse) ]

    Gene ID: 22689, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Zfp27provided by MGI
    Official Full Name
    zinc finger protein 27provided by MGI
    Primary source
    MGI:MGI:99174
    See related
    Ensembl:ENSMUSG00000062040 AllianceGenome:MGI:99174
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mkr-4; Zfp-27; mszf76
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; pancreas; reproductive system; spleen; and urinary system. Orthologous to human ZNF585A (zinc finger protein 585A) and ZNF585B (zinc finger protein 585B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 3.7), whole brain E14.5 (RPKM 3.3) and 28 other tissues See more
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    Genomic context

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    See Zfp27 in Genome Data Viewer
    Location:
    7 B1; 7 17.26 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (29592762..29605976, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (29893331..29906569, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 940 Neighboring gene STARR-positive B cell enhancer ABC_E8836 Neighboring gene STARR-positive B cell enhancer ABC_E10434 Neighboring gene zinc finger protein 420 Neighboring gene STARR-seq mESC enhancer starr_18494 Neighboring gene STARR-positive B cell enhancer ABC_E9288 Neighboring gene microRNA 7668 Neighboring gene zinc finger protein 383 Neighboring gene STARR-seq mESC enhancer starr_18496 Neighboring gene zinc finger protein 74 Neighboring gene RIKEN cDNA C230062I16 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:30738577-30738760

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Iron-inhibited autophagy via transcription factor ZFP27 in Parkinson's disease. Wang Y, et al. J Cell Mol Med, 2023 Nov. PMID 37668106, Free PMC Article
    2. Specific and ubiquitous expression of different Zn finger protein genes in the mouse. Chowdhury K, et al. Nucleic Acids Res, 1988 Nov 11. PMID 3143103, Free PMC Article
    3. Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR. Agata Y, et al. Gene, 1998 Jun 15. PMID 9630514
    4. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
    5. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Iron-inhibited autophagy via transcription factor ZFP27 in Parkinson's disease.
      Title: Iron-inhibited autophagy via transcription factor ZFP27 in Parkinson's disease.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 27
    Names
    protein mKR4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037707.1 → NP_001032796.1  zinc finger protein 27 isoform 1

      See identical proteins and their annotated locations for NP_001032796.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. All four variants encode the same protein.
      Source sequence(s)
      AC149283, BY740816, BY776985
      Consensus CDS
      CCDS21076.1
      UniProtKB/Swiss-Prot
      P10077, Q6PCZ6, Q8CED4
      Related
      ENSMUSP00000054012.9, ENSMUST00000053521.15
      Conserved Domains (5) summary
      COG5048
      Location:317 → 746
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:711 → 731
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:152 → 171
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:2 → 37
      KRAB; KRAB box
      pfam13465
      Location:752 → 775
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001285797.1 → NP_001272726.1  zinc finger protein 27 isoform 1

      See identical proteins and their annotated locations for NP_001272726.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. All four variants encode the same protein.
      Source sequence(s)
      AI854840, AK135293
      Consensus CDS
      CCDS21076.1
      UniProtKB/Swiss-Prot
      P10077, Q6PCZ6, Q8CED4
      Related
      ENSMUSP00000123953.2, ENSMUST00000162592.8
      Conserved Domains (5) summary
      COG5048
      Location:317 → 746
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:711 → 731
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:152 → 171
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:2 → 37
      KRAB; KRAB box
      pfam13465
      Location:752 → 775
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001285798.1 → NP_001272727.1  zinc finger protein 27 isoform 1

      See identical proteins and their annotated locations for NP_001272727.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. All four variants encode the same protein.
      Source sequence(s)
      AI854840, AK028500, AK135293
      Consensus CDS
      CCDS21076.1
      UniProtKB/Swiss-Prot
      P10077, Q6PCZ6, Q8CED4
      Conserved Domains (5) summary
      COG5048
      Location:317 → 746
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:711 → 731
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:152 → 171
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:2 → 37
      KRAB; KRAB box
      pfam13465
      Location:752 → 775
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001421813.1 → NP_001408742.1  zinc finger protein 27 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC149283
      UniProtKB/Swiss-Prot
      P10077, Q6PCZ6, Q8CED4
      Related
      ENSMUSP00000125232.2, ENSMUST00000159920.2

    5. NM_001421814.1 → NP_001408743.1  zinc finger protein 27 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC149283
      UniProtKB/Swiss-Prot
      P10077, Q6PCZ6, Q8CED4

    6. NM_001421815.1 → NP_001408744.1  zinc finger protein 27 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC149283
      UniProtKB/Swiss-Prot
      P10077, Q6PCZ6, Q8CED4

    7. NM_001421816.1 → NP_001408745.1  zinc finger protein 27 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC149283
      UniProtKB/Swiss-Prot
      P10077, Q6PCZ6, Q8CED4

    8. NM_001421817.1 → NP_001408746.1  zinc finger protein 27 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC149283
      UniProtKB/Swiss-Prot
      P10077, Q6PCZ6, Q8CED4

    9. NM_001421818.1 → NP_001408747.1  zinc finger protein 27 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC149283

    10. NM_011754.2 → NP_035884.2  zinc finger protein 27 isoform 1

      See identical proteins and their annotated locations for NP_035884.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. All four variants encode the same protein.
      Source sequence(s)
      AC149283, BB611831, BY776985
      Consensus CDS
      CCDS21076.1
      UniProtKB/Swiss-Prot
      P10077, Q6PCZ6, Q8CED4
      Related
      ENSMUSP00000124684.2, ENSMUST00000161904.8
      Conserved Domains (5) summary
      COG5048
      Location:317 → 746
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:711 → 731
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:152 → 171
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:2 → 37
      KRAB; KRAB box
      pfam13465
      Location:752 → 775
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      29592762..29605976 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242389.2 → XP_030098249.1  zinc finger protein 27 isoform X2

      Conserved Domains (5) summary
      smart00349
      Location:2 → 56
      KRAB; krueppel associated box
      COG5048
      Location:241 → 670
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:635 → 655
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:76 → 95
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:676 → 699
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10077.2 GenPept UniProtKB/Swiss-Prot:P10077

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