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    Galk2 galactokinase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296117, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Galk2provided by RGD
    Official Full Name
    galactokinase 2provided by RGD
    Primary source
    RGD:1308691
    See related
    EnsemblRapid:ENSRNOG00000009289 AllianceGenome:RGD:1308691
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable galactokinase activity. Predicted to be involved in galactose metabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to human GALK2 (galactokinase 2). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Kidney (RPKM 207.2), Adrenal (RPKM 119.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Galk2 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (133563524..133696423)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (113110057..113243014)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (118137097..118268838)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene SECIS binding protein 2-like Neighboring gene TATA element modulatory factor 1, pseudogene 1 Neighboring gene COP9 signalosome subunit 2 Neighboring gene family with sequence similarity 227, member B Neighboring gene fibroblast growth factor 7 Neighboring gene DTW domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Comparison of the enzymatic activities of human galactokinase GALK1 and a related human galactokinase protein GK2. Ai Y, et al. Biochem Biophys Res Commun, 1995 Jul 17. PMID 7542884
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N-acetylgalactosamine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables galactokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables galactokinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables galactokinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in galactose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in galactose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    N-acetylgalactosamine kinase
    Names
    galNAc kinase
    NP_001013941.1
    XP_006234968.1
    XP_017447065.1
    XP_038960484.1
    XP_038960485.1
    XP_038960486.1
    XP_038960488.1
    XP_038960489.1
    XP_038960490.1
    XP_063139392.1
    XP_063139393.1
    XP_063139394.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013919.2 → NP_001013941.1  N-acetylgalactosamine kinase isoform 1

      See identical proteins and their annotated locations for NP_001013941.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q5XIG6
      Conserved Domains (3) summary
      PLN02521
      Location:18 → 455
      PLN02521; galactokinase
      pfam08544
      Location:350 → 430
      GHMP_kinases_C; GHMP kinases C terminal
      pfam10509
      Location:24 → 73
      GalKase_gal_bdg; Galactokinase galactose-binding signature

    2. NM_001430088.1 → NP_001417017.1  N-acetylgalactosamine kinase isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    3. NM_001430089.1 → NP_001417018.1  N-acetylgalactosamine kinase isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A0G2JTQ5

    4. NM_001430090.1 → NP_001417019.1  N-acetylgalactosamine kinase isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    5. NM_001430091.1 → NP_001417020.1  N-acetylgalactosamine kinase isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8L2UPK8

    6. NM_001430092.1 → NP_001417021.1  N-acetylgalactosamine kinase isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    7. NM_001430093.1 → NP_001417022.1  N-acetylgalactosamine kinase isoform 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HPX9

    RNA

    1. NR_190852.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      133563524..133696423
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104560.2 → XP_038960488.1  N-acetylgalactosamine kinase isoform X5

      Conserved Domains (1) summary
      PLN02521
      Location:2 → 431
      PLN02521; galactokinase

    2. XM_063283324.1 → XP_063139394.1  N-acetylgalactosamine kinase isoform X6

    3. XM_063283323.1 → XP_063139393.1  N-acetylgalactosamine kinase isoform X4

    4. XM_039104557.2 → XP_038960485.1  N-acetylgalactosamine kinase isoform X3

      Related
      ENSRNOP00000068802.1, ENSRNOT00000083356.3
      Conserved Domains (1) summary
      PLN02521
      Location:7 → 444
      PLN02521; galactokinase

    5. XM_017591576.3 → XP_017447065.1  N-acetylgalactosamine kinase isoform X7

      Related
      ENSRNOP00000069500.2, ENSRNOT00000079023.3

    6. XM_039104558.2 → XP_038960486.1  N-acetylgalactosamine kinase isoform X9

      Conserved Domains (1) summary
      PLN02521
      Location:29 → 384
      PLN02521; galactokinase

    7. XM_039104556.2 → XP_038960484.1  N-acetylgalactosamine kinase isoform X2

      Related
      ENSRNOP00000108122.1, ENSRNOT00000135446.1
      Conserved Domains (1) summary
      PLN02521
      Location:18 → 394
      PLN02521; galactokinase

    8. XM_006234906.5 → XP_006234968.1  N-acetylgalactosamine kinase isoform X8

      Related
      ENSRNOP00000109188.1, ENSRNOT00000161790.1
      Conserved Domains (2) summary
      PLN02521
      Location:1 → 395
      PLN02521; galactokinase
      pfam08544
      Location:290 → 370
      GHMP_kinases_C; GHMP kinases C terminal

    9. XM_063283322.1 → XP_063139392.1  N-acetylgalactosamine kinase isoform X1

      Related
      ENSRNOP00000012447.6, ENSRNOT00000012447.8

    10. XM_039104562.2 → XP_038960490.1  N-acetylgalactosamine kinase isoform X10

      Conserved Domains (1) summary
      PLN02521
      Location:1 → 267
      PLN02521; galactokinase

    11. XM_039104561.2 → XP_038960489.1  N-acetylgalactosamine kinase isoform X10

      Conserved Domains (1) summary
      PLN02521
      Location:1 → 267
      PLN02521; galactokinase

    RNA

    1. XR_005501815.2 RNA Sequence

    2. XR_005501816.2 RNA Sequence

    3. XR_005501813.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIG6.1 GenPept UniProtKB/Swiss-Prot:Q5XIG6

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