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    selenoi.L selenoprotein I L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 108717272, updated on 4-Nov-2024

    Summary

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    Official Symbol
    selenoi.L
    Official Full Name
    selenoprotein I L homeolog
    Primary source
    Xenbase:XB-GENE-991200
    Locus tag
    XELAEV_18028366mg
    See related
    EnsemblRapid:ENSXLAG00005022779 AllianceGenome:Xenbase:XB-GENE-991200
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    ept1; seli; sepi; ept1.L
    Summary
    The multi-pass transmembrane protein encoded by this gene belongs to the CDP-alcohol phosphatidyltransferase class-I family. It catalyzes the transfer of phosphoethanolamine from CDP-ethanolamine to diacylglycerol to produce phosphatidylethanolamine, which is involved in the formation and maintenance of vesicular membranes, regulation of lipid metabolism, and protein folding. This protein is a selenoprotein, containing the rare selenocysteine (Sec) amino acid at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. A homeolog of this gene is found on chromosome 5S. [provided by RefSeq, Jul 2017]
    Orthologs
    human mouse all
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    Genomic context

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    See selenoi.L in Genome Data Viewer
    Location:
    chromosome: 5L
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 5L NC_054379.1 (168288579..168307504)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 5L NC_030732.1 (156925842..156944900)

    Chromosome 5L - NC_054379.1Genomic Context describing neighboring genes Neighboring gene fucolectin-1-like Neighboring gene fucolectin Neighboring gene dynein regulatory complex subunit 1 L homeolog Neighboring gene otoferlin L homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Selenoprotein Gene Nomenclature. Gladyshev VN, et al. J Biol Chem, 2016 Nov 11. PMID 27645994, Free PMC Article
    2. Composition and evolution of the vertebrate and mammalian selenoproteomes. Mariotti M, et al. PLoS One, 2012. PMID 22479358, Free PMC Article
    3. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC78842

    General protein information

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    Preferred Names
    ethanolaminephosphotransferase 1 L homeolog
    Names
    ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific)
    NP_001078947.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085478.2 → NP_001078947.2  ethanolaminephosphotransferase 1 L homeolog

      Status: REVIEWED

      Source sequence(s)
      BJ066727, BP700124, BU907135, CB591640, CK797970, CK805198, CN320942, CV074132, EB468548, JAGEVR010000051
      UniProtKB/TrEMBL
      A0A8J0PMN0, A0A974CUU0
      Related
      ENSXLAP00005067124.1, ENSXLAT00005068652.1
      Conserved Domains (1) summary
      cl00453
      Location:5 → 300
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054379.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      168288579..168307504
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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