ASB15 ankyrin repeat and SOCS box containing 15 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ASB15provided by HGNC
Official Full Name: ankyrin repeat and SOCS box containing 15provided by HGNC
Primary source: HGNC:HGNC:19767
See related: Ensembl:ENSG00000146809 MIM:619757; AllianceGenome:HGNC:19767
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: This gene encodes a member of the suppressor of cytokine signaling box superfamily. The proteins in this superfamily participate in the ubiquitin-proteasome system for the degradation of proteins in the cell cycle and signal transduction pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Expression: Biased expression in heart (RPKM 6.0), kidney (RPKM 2.1) and 2 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q31.32

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (123567008..123639481)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (124883774..124956264)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (123241875..123279535)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genome-wide association study reveals two novel risk alleles for incident obstructive sleep apnea in the EPISONO cohort.
Title: Genome-wide association study reveals two novel risk alleles for incident obstructive sleep apnea in the EPISONO cohort.
The apparent occurrence of an unusual TG 3' splice site in intron 9 is critically discussed.
Title: Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.
ASB15 gene, consisting of 12 exons, was identified by using bio-informatics.
Title: Identification and characterization of ankyrin repeat and SOCS box-containing gene ASB15 in silico.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH98583 (e-PCR)
- UniSTS:85533

NoName (e-PCR)
- UniSTS:482990

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Golgi to lysosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in retrograde transport, endosome to Golgi	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
is_active_in endosome membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ankyrin repeat and SOCS box protein 15

Names: epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_034019.2 RefSeqGene

Range

39815..77475

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001290258.2 → NP_001277187.1 ankyrin repeat and SOCS box protein 15

See identical proteins and their annotated locations for NP_001277187.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC006333, AF403033, AK125360, BC100874, CR749595

Consensus CDS

CCDS34742.1

UniProtKB/Swiss-Prot

Q3ZCP3, Q3ZCP5, Q68D37, Q8WXK1

UniProtKB/TrEMBL

A0A384NYV2

Related

ENSP00000416433.1, ENST00000451215.6

Conserved Domains (4) summary

COG0666
Location:25 → 205

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00204
Location:138 → 263

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:178 → 207

ANK; ANK repeat [structural motif]

cl02533
Location:532 → 587

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
NM_080928.4 → NP_563616.3 ankyrin repeat and SOCS box protein 15

See identical proteins and their annotated locations for NP_563616.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AC006333, AF403033, AK125360, BC100874, CR749595

Consensus CDS

CCDS34742.1

UniProtKB/Swiss-Prot

Q3ZCP3, Q3ZCP5, Q68D37, Q8WXK1

UniProtKB/TrEMBL

A0A384NYV2

Related

ENSP00000275699.3, ENST00000275699.4

Conserved Domains (4) summary

COG0666
Location:25 → 205

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00204
Location:138 → 263

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:178 → 207

ANK; ANK repeat [structural motif]

cl02533
Location:532 → 587

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000007.14 Reference GRCh38.p14 Primary Assembly

Range

123567008..123639481

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011515819.3 → XP_011514121.1 ankyrin repeat and SOCS box protein 15 isoform X2

See identical proteins and their annotated locations for XP_011514121.1

UniProtKB/Swiss-Prot

Q3ZCP3, Q3ZCP5, Q68D37, Q8WXK1

UniProtKB/TrEMBL

A0A384NYV2

Related

ENSP00000397655.1, ENST00000451558.5

Conserved Domains (4) summary

COG0666
Location:25 → 205

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00204
Location:138 → 263

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:178 → 207

ANK; ANK repeat [structural motif]

cl02533
Location:532 → 587

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
XM_017011757.2 → XP_016867246.1 ankyrin repeat and SOCS box protein 15 isoform X2

UniProtKB/Swiss-Prot

Q3ZCP3, Q3ZCP5, Q68D37, Q8WXK1

UniProtKB/TrEMBL

A0A384NYV2

Conserved Domains (4) summary

COG0666
Location:25 → 205

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00204
Location:138 → 263

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:178 → 207

ANK; ANK repeat [structural motif]

cl02533
Location:532 → 587

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
XM_011515818.3 → XP_011514120.1 ankyrin repeat and SOCS box protein 15 isoform X2

See identical proteins and their annotated locations for XP_011514120.1

UniProtKB/Swiss-Prot

Q3ZCP3, Q3ZCP5, Q68D37, Q8WXK1

UniProtKB/TrEMBL

A0A384NYV2

Conserved Domains (4) summary

COG0666
Location:25 → 205

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00204
Location:138 → 263

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:178 → 207

ANK; ANK repeat [structural motif]

cl02533
Location:532 → 587

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
XM_011515817.3 → XP_011514119.1 ankyrin repeat and SOCS box protein 15 isoform X2

See identical proteins and their annotated locations for XP_011514119.1

UniProtKB/Swiss-Prot

Q3ZCP3, Q3ZCP5, Q68D37, Q8WXK1

UniProtKB/TrEMBL

A0A384NYV2

Conserved Domains (4) summary

COG0666
Location:25 → 205

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00204
Location:138 → 263

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:178 → 207

ANK; ANK repeat [structural motif]

cl02533
Location:532 → 587

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
XM_005250146.5 → XP_005250203.1 ankyrin repeat and SOCS box protein 15 isoform X2

See identical proteins and their annotated locations for XP_005250203.1

UniProtKB/Swiss-Prot

Q3ZCP3, Q3ZCP5, Q68D37, Q8WXK1

UniProtKB/TrEMBL

A0A384NYV2

Conserved Domains (4) summary

COG0666
Location:25 → 205

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00204
Location:138 → 263

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:178 → 207

ANK; ANK repeat [structural motif]

cl02533
Location:532 → 587

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
XM_011515820.3 → XP_011514122.1 ankyrin repeat and SOCS box protein 15 isoform X2

See identical proteins and their annotated locations for XP_011514122.1

UniProtKB/Swiss-Prot

Q3ZCP3, Q3ZCP5, Q68D37, Q8WXK1

UniProtKB/TrEMBL

A0A384NYV2

Conserved Domains (4) summary

COG0666
Location:25 → 205

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00204
Location:138 → 263

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:178 → 207

ANK; ANK repeat [structural motif]

cl02533
Location:532 → 587

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
XM_011515816.3 → XP_011514118.1 ankyrin repeat and SOCS box protein 15 isoform X1

Conserved Domains (4) summary

cd00204
Location:144 → 269

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:121 → 213

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:184 → 213

ANK; ANK repeat [structural motif]

cl02533
Location:538 → 593

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
XM_011515821.3 → XP_011514123.1 ankyrin repeat and SOCS box protein 15 isoform X3

Conserved Domains (4) summary

cd00204
Location:131 → 249

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:135 → 226

Ank_2; Ankyrin repeats (3 copies)

sd00045
Location:131 → 160

ANK; ANK repeat [structural motif]

cl02533
Location:485 → 540

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
XM_017011756.3 → XP_016867245.1 ankyrin repeat and SOCS box protein 15 isoform X2

UniProtKB/Swiss-Prot

Q3ZCP3, Q3ZCP5, Q68D37, Q8WXK1

UniProtKB/TrEMBL

A0A384NYV2

Conserved Domains (4) summary

COG0666
Location:25 → 205

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

cd00204
Location:138 → 263

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

sd00045
Location:178 → 207

ANK; ANK repeat [structural motif]

cl02533
Location:532 → 587

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
XM_017011758.2 → XP_016867247.1 ankyrin repeat and SOCS box protein 15 isoform X4

Alternate T2T-CHM13v2.0

Genomic

NC_060931.1 Alternate T2T-CHM13v2.0

Range

124883774..124956264

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054357296.1 → XP_054213271.1 ankyrin repeat and SOCS box protein 15 isoform X2
XM_054357298.1 → XP_054213273.1 ankyrin repeat and SOCS box protein 15 isoform X2
XM_054357294.1 → XP_054213269.1 ankyrin repeat and SOCS box protein 15 isoform X2
XM_054357292.1 → XP_054213267.1 ankyrin repeat and SOCS box protein 15 isoform X2
XM_054357293.1 → XP_054213268.1 ankyrin repeat and SOCS box protein 15 isoform X2
XM_054357295.1 → XP_054213270.1 ankyrin repeat and SOCS box protein 15 isoform X2
XM_054357291.1 → XP_054213266.1 ankyrin repeat and SOCS box protein 15 isoform X1
XM_054357299.1 → XP_054213274.1 ankyrin repeat and SOCS box protein 15 isoform X3
XM_054357297.1 → XP_054213272.1 ankyrin repeat and SOCS box protein 15 isoform X2
XM_054357300.1 → XP_054213275.1 ankyrin repeat and SOCS box protein 15 isoform X4