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    OVOS2 alpha-2-macroglobulin like 1 pseudogene [ Homo sapiens (human) ]

    Gene ID: 144203, updated on 17-Sep-2024

    Summary

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    Gene symbol
    OVOS2
    Gene description
    alpha-2-macroglobulin like 1 pseudogene
    See related
    Ensembl:ENSG00000177359
    Gene type
    pseudo
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Biased expression in testis (RPKM 5.2), small intestine (RPKM 0.8) and 3 other tissues See more
    Orthologs
    all
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    Genomic context

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    See OVOS2 in Genome Data Viewer
    Location:
    12p11.21
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (31111652..31201235, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (30986156..31077760, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (31264586..31354169, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr12:31181720-31181949 Neighboring gene DDX11 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 7044 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:31226445-31226976 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:31227509-31228038 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:31232984-31233540 Neighboring gene DEAD/H-box helicase 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:31256969-31257468 Neighboring gene MPRA-validated peak1651 silencer Neighboring gene uncharacterized LOC124902912 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:31270198-31270728 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:31270729-31271258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:31273911-31274440 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:31373729-31374473 Neighboring gene uncharacterized LOC107987168 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:31381449-31382006 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_28233 Neighboring gene MT-ND5 pseudogene 43

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Expression analysis of ovostatin 2 reveals its involvement in proliferation, invasion and angiogenesis of cutaneous malignant melanoma. Huang YX, et al. J Dermatol, 2013 Nov. PMID 24112097
    2. Novel association strategy with copy number variation for identifying new risk Loci of human diseases. Chen X, et al. PLoS One, 2010 Aug 20. PMID 20808825, Free PMC Article
    3. A genomic analysis of rat proteases and protease inhibitors. Puente XS, et al. Genome Res, 2004 Apr. PMID 15060002, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. expression significantly increased incrementally from benign nevi to cutaneous malignant melanoma
      Title: Expression analysis of ovostatin 2 reveals its involvement in proliferation, invasion and angiogenesis of cutaneous malignant melanoma.
    2. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Novel association strategy with copy number variation for identifying new risk Loci of human diseases.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Other Names

    • ovostatin homolog 2

    Clone Names

    • DKFZp686C0338

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_153414.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC008010, AC008013, AC024940, AW246438, BC039117, BN000357, BU732570, DV080134, EG328042
      Related
      ENST00000641844.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      31111652..31201235 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187587.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      173..92029 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      30986156..31077760 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001080502.1: Suppressed sequence

      Description
      NM_001080502.1: This RefSeq was removed because currently there is insufficient support for the transcript and protein.

    2. NM_173498.1: Suppressed sequence

      Description
      NM_173498.1: This RefSeq was removed because there is insufficient support for the transcript and protein.
    Nucleotide Protein
    Heading Accession and Version

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