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    Gabrg3 gamma-aminobutyric acid type A receptor, subunit gamma 3 [ Mus musculus (house mouse) ]

    Gene ID: 14407, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gabrg3provided by MGI
    Official Full Name
    gamma-aminobutyric acid type A receptor, subunit gamma 3provided by MGI
    Primary source
    MGI:MGI:95624
    See related
    Ensembl:ENSMUSG00000055026 AllianceGenome:MGI:95624
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gabrg-3; 6330406O05Rik; B230362M20Rik
    Summary
    Enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in several processes, including GABAergic synaptic transmission; chloride transmembrane transport; and inhibitory synapse assembly. Is active in GABA-ergic synapse and synaptic membrane. Is expressed in brain; dentate gyrus subgranular zone; dorsal striatum; lens; and ventral striatum. Orthologous to human GABRG3 (gamma-aminobutyric acid type A receptor subunit gamma3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 2.1), cortex adult (RPKM 2.0) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gabrg3 in Genome Data Viewer
    Location:
    7 B5; 7 33.48 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (56366211..57037173, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (56716463..57387215, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene HECT and RLD domain containing E3 ubiquitin protein ligase 2 Neighboring gene STARR-seq mESC enhancer starr_18966 Neighboring gene solute carrier family 1 (neutral amino acid transporter), member 5 pseudogene Neighboring gene oculocutaneous albinism II Neighboring gene STARR-seq mESC enhancer starr_18969 Neighboring gene predicted gene, 17984 Neighboring gene carbonic anhydrase 8 pseudogene Neighboring gene STARR-seq mESC enhancer starr_18970 Neighboring gene STARR-seq mESC enhancer starr_18971 Neighboring gene coronin, actin binding protein 1B pseudogene Neighboring gene STARR-seq mESC enhancer starr_18972 Neighboring gene vaccinia related kinase 3 pseudogene Neighboring gene predicted gene, 39017 Neighboring gene predicted gene 9962 Neighboring gene STARR-seq mESC enhancer starr_18974 Neighboring gene gamma-aminobutyric acid type A receptor subunit alpha 5 Neighboring gene STARR-seq mESC enhancer starr_18975 Neighboring gene STARR-seq mESC enhancer starr_18976 Neighboring gene microRNA 6389 Neighboring gene GABRB3, gamma-aminobutyric acid type A receptor subunit beta 3 Neighboring gene STARR-seq mESC enhancer starr_18977

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel gamma subunit of the GABAA receptor identified using the polymerase chain reaction. Wilson-Shaw D, et al. FEBS Lett, 1991 Jun 24. PMID 1647983
    2. Antagonism of fenfluramine-induced hyperthermia: a measure of central serotonin inhibition. Sulpizio A, et al. Life Sci, 1978 Apr 24. PMID 27681
    3. Postsynaptic clustering of gamma-aminobutyric acid type A receptors by the gamma3 subunit in vivo. Baer K, et al. Proc Natl Acad Sci U S A, 1999 Oct 26. PMID 10536013, Free PMC Article
    4. Phenotypic consequences of deletion of the gamma 3, alpha 5, or beta 3 subunit of the type A gamma-aminobutyric acid receptor in mice. Culiat CT, et al. Proc Natl Acad Sci U S A, 1994 Mar 29. PMID 8146195, Free PMC Article
    5. GABAA-receptor alpha-subunit is an essential prerequisite for receptor formation in vivo. Fritschy JM, et al. Neuroscience, 1997 Dec. PMID 9330366

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to GABA-A receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GABA-A receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables GABA-A receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables GABA-gated chloride ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GABA-gated chloride ion channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    contributes_to benzodiazepine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chloride channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in gamma-aminobutyric acid signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gamma-aminobutyric acid signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inhibitory synapse assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in synaptic transmission, GABAergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of GABA-A receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in GABA-ergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of chloride channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in dendrite membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    gamma-aminobutyric acid receptor subunit gamma-3
    Names
    GABAAR subunit gamma-3
    gamma-aminobutyric acid (GABA) A receptor, subunit gamma 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008074.3 → NP_032100.2  gamma-aminobutyric acid receptor subunit gamma-3 precursor

      See identical proteins and their annotated locations for NP_032100.2

      Status: VALIDATED

      Source sequence(s)
      AC102098, AC102129, AC116146, AK046263
      Consensus CDS
      CCDS21320.1
      UniProtKB/Swiss-Prot
      G5E8E8, P27681
      Related
      ENSMUSP00000067632.7, ENSMUST00000068911.13
      Conserved Domains (2) summary
      TIGR00860
      Location:50 → 464
      LIC; Cation transporter family protein
      cd19000
      Location:71 → 252
      LGIC_ECD_GABAAR_G; extracellular domain of gamma-aminobutyric acid receptor subunit gamma

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      56366211..57037173 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321978.3 → XP_017177467.1  gamma-aminobutyric acid receptor subunit gamma-3 isoform X1

      Conserved Domains (2) summary
      TIGR00860
      Location:50 → 465
      LIC; Cation transporter family protein
      cd19000
      Location:71 → 252
      LGIC_ECD_GABAAR_G; extracellular domain of gamma-aminobutyric acid receptor subunit gamma

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177273.1: Suppressed sequence

      Description
      NM_177273.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27681.2 GenPept UniProtKB/Swiss-Prot:P27681

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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