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    AICDA activation induced cytidine deaminase [ Canis lupus familiaris (dog) ]

    Gene ID: 442983, updated on 17-Aug-2024

    Summary

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    Official Symbol
    AICDAprovided by VGNC
    Official Full Name
    activation induced cytidine deaminaseprovided by VGNC
    Primary source
    VGNC:VGNC:37733
    See related
    Ensembl:ENSCAFG00845029609
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Canis lupus familiaris (sub-species: familiaris)
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
    Also known as
    AID
    Orthologs
    human mouse all
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    Genomic context

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    See AICDA in Genome Data Viewer
    Location:
    chromosome: 27
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current ROS_Cfam_1.0 (GCF_014441545.1) 27 NC_051831.1 (37413568..37423269)
    106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 27 NC_006609.4 (9542544..9552236, complement)
    106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 27 NC_049248.1 (9029099..9038784, complement)
    106 current UMICH_Zoey_3.1 (GCF_005444595.1) 27 NC_049287.1 (37294310..37303981)
    106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 27 NC_049768.1 (37329570..37339245)

    Chromosome 27 - NC_051831.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene ribosomal modification protein rimK like family member B Neighboring gene uncharacterized LOC119866427 Neighboring gene microfibril associated protein 5 Neighboring gene U6 spliceosomal RNA Neighboring gene apolipoprotein B mRNA editing enzyme catalytic subunit 1 Neighboring gene developmental pluripotency associated 3 Neighboring gene growth differentiation factor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of canine activation-induced cytidine deaminase (AID) cDNA and its expression in normal tissues. Ohmori K, et al. J Vet Med Sci, 2004 Jun. PMID 15240955
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cytidine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA cytosine deamination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cytidine to uridine editing IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P-body IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    single-stranded DNA cytosine deaminase
    Names
    cytidine aminohydrolase
    NP_001003380.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003380.1 → NP_001003380.1  single-stranded DNA cytosine deaminase

      See identical proteins and their annotated locations for NP_001003380.1

      Status: PROVISIONAL

      Source sequence(s)
      AB122019
      UniProtKB/Swiss-Prot
      Q75W64
      UniProtKB/TrEMBL
      A0A8C0JQE4
      Related
      ENSCAFP00845041144.1, ENSCAFT00845052443.1
      Conserved Domains (3) summary
      cd01283
      Location:5 → 129
      cytidine_deaminase; Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on ...
      pfam05240
      Location:124 → 165
      APOBEC_C; APOBEC-like C-terminal domain
      pfam08210
      Location:11 → 178
      APOBEC_N; APOBEC-like N-terminal domain

    RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ROS_Cfam_1.0

    Genomic

    1. NC_051831.1 Reference ROS_Cfam_1.0

      Range
      37413568..37423269
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UMICH_Zoey_3.1

    Genomic

    1. NC_049287.1 Alternate UMICH_Zoey_3.1

      Range
      37294310..37303981
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UNSW_CanFamBas_1.0

    Genomic

    1. NC_049768.1 Alternate UNSW_CanFamBas_1.0

      Range
      37329570..37339245
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate UU_Cfam_GSD_1.0

    Genomic

    1. NC_049248.1 Alternate UU_Cfam_GSD_1.0

      Range
      9029099..9038784 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Dog10K_Boxer_Tasha Primary Assembly

    Genomic

    1. NC_006609.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

      Range
      9542544..9552236 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q75W64.1 GenPept UniProtKB/Swiss-Prot:Q75W64

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials