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    prcp prolylcarboxypeptidase (angiotensinase C) [ Danio rerio (zebrafish) ]

    Gene ID: 436967, updated on 2-Nov-2024

    Summary

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    Official Symbol
    prcpprovided by ZNC
    Official Full Name
    prolylcarboxypeptidase (angiotensinase C)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040718-447
    See related
    Ensembl:ENSDARG00000037883 AllianceGenome:ZFIN:ZDB-GENE-040718-447
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:91816
    Summary
    Predicted to enable dipeptidyl-peptidase activity. Predicted to be involved in angiogenesis involved in wound healing; negative regulation of systemic arterial blood pressure; and regulation of blood vessel endothelial cell migration. Predicted to act upstream of or within proteolysis. Is expressed in blood cell; vascular endothelium; and vein. Orthologous to human PRCP (prolylcarboxypeptidase). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See prcp in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (11218246..11303691, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (11295851..11381489, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 181 member B Neighboring gene uncharacterized LOC137487721 Neighboring gene RAB30, member RAS oncogene family Neighboring gene NADH:ubiquinone oxidoreductase subunit C2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Structural libraries of protein models for multiple species to understand evolution of the renin-angiotensin system. Prokop JW, et al. Gen Comp Endocrinol, 2015 May 1. PMID 25260253, Free PMC Article
    2. Global analysis of the haematopoietic and endothelial transcriptome during zebrafish development. Cannon JE, et al. Mech Dev, 2013 Feb. PMID 23072875, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dipeptidyl-peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type exopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in angiogenesis involved in wound healing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of systemic arterial blood pressure IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of blood vessel endothelial cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    lysosomal Pro-X carboxypeptidase
    NP_001002694.1
    XP_009289787.1
    XP_009289788.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002694.1 → NP_001002694.1  lysosomal Pro-X carboxypeptidase precursor

      See identical proteins and their annotated locations for NP_001002694.1

      Status: PROVISIONAL

      Source sequence(s)
      BC076507
      UniProtKB/TrEMBL
      A0A8M1N154, Q6DG46
      Related
      ENSDARP00000077802.3, ENSDART00000083367.5
      Conserved Domains (1) summary
      cl21494
      Location:54 → 476
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      11218246..11303691 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009291512.4 → XP_009289787.1  lysosomal Pro-X carboxypeptidase isoform X1

      UniProtKB/TrEMBL
      A0A8M3ASI7
      Conserved Domains (1) summary
      cl21494
      Location:54 → 507
      Abhydrolase; alpha/beta hydrolases

    2. XM_009291513.4 → XP_009289788.1  lysosomal Pro-X carboxypeptidase isoform X2

      UniProtKB/TrEMBL
      A0A8M3APM0
      Conserved Domains (1) summary
      cl21494
      Location:54 → 362
      Abhydrolase; alpha/beta hydrolases

    RNA

    1. XR_658287.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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