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    Mrgprx2 MAS related GPR family member X2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 404640, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mrgprx2provided by RGD
    Official Full Name
    MAS related GPR family member X2provided by RGD
    Primary source
    RGD:738048
    See related
    AllianceGenome:RGD:738048
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mgrg6; MrgB1; Mrgprb1
    Summary
    Predicted to enable mast cell secretagogue receptor activity and neuropeptide binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway; mast cell degranulation; and positive regulation of cytokinesis. Predicted to be active in plasma membrane. Orthologous to human MRGPRX2 (MAS related GPR family member X2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See Mrgprx2 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (107252467..107271809, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (98116192..98135534, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (103743746..103760945, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene mas-related G-protein coupled receptor member B8-like Neighboring gene mas-related G-protein coupled receptor member B8-like Neighboring gene MAS-related G protein-coupled receptor, member X2-like Neighboring gene fatty acyl CoA reductase 1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mas-related gene X2 (MrgX2) is a novel G protein-coupled receptor for the antimicrobial peptide LL-37 in human mast cells: resistance to receptor phosphorylation, desensitization, and internalization. Subramanian H, et al. J Biol Chem, 2011 Dec 30. PMID 22069323, Free PMC Article
    2. MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion. Robas N, et al. J Biol Chem, 2003 Nov 7. PMID 12915402
    3. Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions. McNeil BD, et al. Nature, 2015 Mar 12. PMID 25517090, Free PMC Article
    4. G protein-coupled receptors participate in cytokinesis. Zhang X, et al. Cytoskeleton (Hoboken), 2012 Oct. PMID 22888021, Free PMC Article
    5. Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family. Zylka MJ, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12909716, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables mast cell secretagogue receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables neuropeptide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mast cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mast cell degranulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mas-related G-protein coupled receptor member X2
    Names
    MAS-related G protein-coupled receptor, member B1
    MAS-related GPR, member X2
    MAS-related gene B1
    Mas-related G protein-coupled receptor g6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002280.1 → NP_001002280.1  mas-related G-protein coupled receptor member X2

      See identical proteins and their annotated locations for NP_001002280.1

      Status: PROVISIONAL

      Source sequence(s)
      AF518239
      UniProtKB/TrEMBL
      Q7TN48
      Conserved Domains (2) summary
      pfam00001
      Location:25 → 256
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:21 → 187
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      107252467..107271809 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017589513.2 → XP_017445002.1  mas-related G-protein coupled receptor member X2 isoform X1

      UniProtKB/TrEMBL
      F7F3V7
    Nucleotide Protein Strain
    Heading Accession and Version

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