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    LIPE lipase E, hormone sensitive type [ Sus scrofa (pig) ]

    Gene ID: 397583, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LIPEprovided by VGNC
    Official Full Name
    lipase E, hormone sensitive typeprovided by VGNC
    Primary source
    VGNC:VGNC:98493
    See related
    Ensembl:ENSSSCG00000003018
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Sus scrofa
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
    Also known as
    HSL; REH
    Expression
    Biased expression in subcutaneous adipose (RPKM 331.9) and longissimus dorsi muscle (RPKM 13.7) See more
    Orthologs
    human mouse all
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    Genomic context

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    See LIPE in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current Sscrofa11.1 (GCF_000003025.6) 6 NC_010448.4 (49543671..49560126)
    105 previous assembly Sscrofa10.2 (GCF_000003025.5) 6 NC_010448.3 (45443742..45454621)

    Chromosome 6 - NC_010448.4Genomic Context describing neighboring genes Neighboring gene distal membrane arm assembly component 2 Neighboring gene CEA cell adhesion molecule 1 Neighboring gene enolase-phosphatase E1 pseudogene Neighboring gene cornifelin Neighboring gene multiple EGF like domains 8 Neighboring gene transmembrane protein 145

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
    • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
    • BioProject: PRJNA311523
    • Publication: PMID 27646534
    • Analysis date: Thu Dec 14 17:10:49 2017

    Bibliography

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    Related articles in PubMed

    1. The porcine hormone-sensitive lipase gene: sequence, structure, polymorphisms and linkage mapping. Harbitz I, et al. Anim Genet, 1999 Feb. PMID 10050278
    2. Differential responses of hormone-sensitive lipase gene to nutritional transition in adipose tissue, liver, and skeletal muscle of pigs. Liu CY, et al. Biochem Mol Biol Int, 1995 Jul. PMID 7549969
    3. FISH on metaphase and interphase chromosomes demonstrates the physical order of the genes for GPI, CRC, and LIPE in pigs. Chowdhary BP, et al. Cytogenet Cell Genet, 1995. PMID 7656591
    4. Chromosomal localization of the hormone sensitive lipase (LIPE) and insulin receptor (INSR) genes in pigs. Gu F, et al. Hereditas, 1992. PMID 1295851
    5. Effect of feed restriction on adipose tissue transcript concentrations in genetically lean and obese pigs. McNeel RL, et al. J Anim Sci, 2000 Apr. PMID 10784183

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables sterol ester esterase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables triacylglycerol lipase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in triglyceride catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hormone-sensitive lipase
    Names
    monoacylglycerol lipase LIPE
    retinyl ester hydrolase
    NP_999480.2
    XP_013844054.2
    XP_013844055.1
    XP_013844056.1
    XP_020949233.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214315.3 → NP_999480.2  hormone-sensitive lipase

      Status: PROVISIONAL

      Source sequence(s)
      AEMK02000041
      UniProtKB/TrEMBL
      A0A8D1PVS2, A0A8D1XXL4
      Conserved Domains (2) summary
      pfam06350
      Location:6 → 314
      HSL_N; Hormone-sensitive lipase (HSL) N-terminus
      cl21494
      Location:346 → 494
      Abhydrolase; alpha/beta hydrolases

    RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Sscrofa11.1 Primary Assembly

    Genomic

    1. NC_010448.4 Reference Sscrofa11.1 Primary Assembly

      Range
      49543671..49560126
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021093574.1 → XP_020949233.1  hormone-sensitive lipase isoform X2

      UniProtKB/TrEMBL
      A0A286ZT25, A0A4X1SKS6, A0A8D1MT16
      Related
      ENSSSCP00000003269.3, ENSSSCT00000003352.4
      Conserved Domains (2) summary
      pfam06350
      Location:52 → 360
      HSL_N; Hormone-sensitive lipase (HSL) N-terminus
      cl21494
      Location:392 → 540
      Abhydrolase; alpha/beta hydrolases

    2. XM_013988600.2 → XP_013844054.2  hormone-sensitive lipase isoform X1

      UniProtKB/TrEMBL
      A0A4X1SJC7, A0A8D1L7S7
      Conserved Domains (2) summary
      pfam06350
      Location:57 → 365
      HSL_N; Hormone-sensitive lipase (HSL) N-terminus
      cl21494
      Location:397 → 545
      Abhydrolase; alpha/beta hydrolases

    3. XM_013988602.2 → XP_013844056.1  hormone-sensitive lipase isoform X3

      UniProtKB/TrEMBL
      A0A8D1PVS2, A0A8D1XXL4
      Conserved Domains (2) summary
      pfam06350
      Location:6 → 314
      HSL_N; Hormone-sensitive lipase (HSL) N-terminus
      cl21494
      Location:346 → 494
      Abhydrolase; alpha/beta hydrolases

    4. XM_013988601.2 → XP_013844055.1  hormone-sensitive lipase isoform X3

      UniProtKB/TrEMBL
      A0A8D1PVS2, A0A8D1XXL4
      Conserved Domains (2) summary
      pfam06350
      Location:6 → 314
      HSL_N; Hormone-sensitive lipase (HSL) N-terminus
      cl21494
      Location:346 → 494
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q68J42.1 GenPept UniProtKB/Swiss-Prot:Q68J42

    Gene LinkOut

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