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    Pde7b phosphodiesterase 7B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 140929, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Pde7bprovided by RGD
    Official Full Name
    phosphodiesterase 7Bprovided by RGD
    Primary source
    RGD:621016
    See related
    EnsemblRapid:ENSRNOG00000013436 AllianceGenome:RGD:621016
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables 3',5'-cyclic-AMP phosphodiesterase activity. Predicted to be involved in cAMP-mediated signaling. Predicted to be active in cytosol; nucleus; and perinuclear region of cytoplasm. Orthologous to human PDE7B (phosphodiesterase 7B). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Kidney (RPKM 117.0), Muscle (RPKM 90.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pde7b in Genome Data Viewer
    Location:
    1p12
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (16994072..17312828, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (15174001..15493267, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (15889845..16203909, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene BCL2-associated transcription factor 1 Neighboring gene mitochondrial fission regulator 2 Neighboring gene uncharacterized LOC134484964 Neighboring gene uncharacterized LOC134484963 Neighboring gene histidine-rich glycoprotein-like Neighboring gene uncharacterized LOC120098802 Neighboring gene small nucleolar RNA SNORA41

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Transcriptional activation of phosphodiesterase 7B1 by dopamine D1 receptor stimulation through the cyclic AMP/cyclic AMP-dependent protein kinase/cyclic AMP-response element binding protein pathway in primary striatal neurons. Sasaki T, et al. J Neurochem, 2004 Apr. PMID 15056290
    2. Novel alternative splice variants of rat phosphodiesterase 7B showing unique tissue-specific expression and phosphorylation. Sasaki T, et al. Biochem J, 2002 Jan 15. PMID 11772393, Free PMC Article
    3. Dopamine D1, D2 and mu-opioid receptors are co-expressed with adenylyl cyclase 5 and phosphodiesterase 7B mRNAs in striatal rat cells. de Gortari P, et al. Brain Res, 2010 Jan 15. PMID 19913519
    4. Cloning and characterization of the human and mouse PDE7B, a novel cAMP-specific cyclic nucleotide phosphodiesterase. Gardner C, et al. Biochem Biophys Res Commun, 2000 May 27. PMID 10872825
    5. Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. Conti M, et al. Annu Rev Biochem, 2007. PMID 17376027

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. All MOR, D1 and D2 positive cells containing AC5 mRNA simultaneously express PDE7B in striatal rat cells.
      Title: Dopamine D1, D2 and mu-opioid receptors are co-expressed with adenylyl cyclase 5 and phosphodiesterase 7B mRNAs in striatal rat cells.
    2. These data demonstrate the dopamine D1 receptor-mediated transcriptional activation of PDE7B through the cAMP/cAMP-dependent protein kinase/cAMP-response element binding protein pathway in striatal neurons
      Title: Transcriptional activation of phosphodiesterase 7B1 by dopamine D1 receptor stimulation through the cyclic AMP/cyclic AMP-dependent protein kinase/cyclic AMP-response element binding protein pathway in primary striatal neurons.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cAMP-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cAMP-mediated signaling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    3',5'-cyclic-AMP phosphodiesterase 7B
    Names
    cAMP-specific 3',5'-cyclic phosphodiesterase 7B
    NP_543170.1
    XP_008756813.1
    XP_008756814.1
    XP_038938754.1
    XP_038938792.1
    XP_038938818.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080894.2 → NP_543170.1  3',5'-cyclic-AMP phosphodiesterase 7B

      See identical proteins and their annotated locations for NP_543170.1

      Status: PROVISIONAL

      Source sequence(s)
      AB057409
      UniProtKB/TrEMBL
      A6JPD2, Q8VIE4
      Related
      ENSRNOP00000070401.1, ENSRNOT00000078586.3
      Conserved Domains (1) summary
      pfam00233
      Location:172 → 406
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      16994072..17312828 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039082826.2 → XP_038938754.1  3',5'-cyclic-AMP phosphodiesterase 7B isoform X2

      UniProtKB/TrEMBL
      A6JPD3
      Conserved Domains (1) summary
      pfam00233
      Location:224 → 427
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    2. XM_039082864.2 → XP_038938792.1  3',5'-cyclic-AMP phosphodiesterase 7B isoform X3

      UniProtKB/TrEMBL
      A0A8I6AIQ8, F1LN39, Q8VIE2
      Related
      ENSRNOP00000018556.6, ENSRNOT00000018556.8
      Conserved Domains (1) summary
      pfam00233
      Location:185 → 419
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    3. XM_008758591.4 → XP_008756813.1  3',5'-cyclic-AMP phosphodiesterase 7B isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZWQ4, A6JPD3
      Related
      ENSRNOP00000094058.2, ENSRNOT00000101303.2
      Conserved Domains (1) summary
      pfam00233
      Location:224 → 458
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    4. XM_039082890.2 → XP_038938818.1  3',5'-cyclic-AMP phosphodiesterase 7B isoform X4

      UniProtKB/TrEMBL
      A0A8I6A9G5, Q8VIE3
      Conserved Domains (1) summary
      pfam00233
      Location:85 → 319
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    5. XM_008758592.4 → XP_008756814.1  3',5'-cyclic-AMP phosphodiesterase 7B isoform X4

      See identical proteins and their annotated locations for XP_008756814.1

      UniProtKB/TrEMBL
      A0A8I6A9G5, Q8VIE3
      Related
      ENSRNOP00000088274.2, ENSRNOT00000117741.2
      Conserved Domains (1) summary
      pfam00233
      Location:85 → 319
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

    RNA

    1. XR_005488707.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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