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    SC35 SR family splicing factor SC35 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 53444, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SC35provided by FlyBase
    Official Full Name
    SR family splicing factor SC35provided by FlyBase
    Primary source
    FLYBASE:FBgn0265298
    Locus tag
    Dmel_CG5442
    See related
    AllianceGenome:FB:FBgn0265298
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Posey284; CG15494; cg5442; CG5442; CG5542; Dmel\CG5442; dSC35; SC-35; sc35; Sc35
    Summary
    Enables mRNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome; regulation of mRNA 3'-end processing; and regulation of transcriptional start site selection at RNA polymerase II promoter. Located in chromatin and nuclear speck. Is expressed in several structures, including adult heart; anterior endoderm; embryonic/larval midgut primordium; ganglia; and mesoderm. Human ortholog(s) of this gene implicated in acute myeloid leukemia; congestive heart failure; hepatocellular carcinoma; and myelodysplastic syndrome. Orthologous to several human genes including SRSF2 (serine and arginine rich splicing factor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

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    See SC35 in Genome Data Viewer
    Location:
    33E4-33E4; 2-46 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12431075..12434665, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12431075..12434665, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene tRNA methyltransferase 1 Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene eukaryotic translation release factor 3 Neighboring gene Organic anion transporting polypeptide 33Ea Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phosphorylation status of the Kep1 protein alters its affinity for its protein binding partner alternative splicing factor ASF/SF2. Robard C, et al. Biochem J, 2006 Nov 15. PMID 16834570, Free PMC Article
    2. Spargel/dPGC-1 is a new downstream effector in the insulin-TOR signaling pathway in Drosophila. Mukherjee S, et al. Genetics, 2013 Oct. PMID 23934892, Free PMC Article
    3. The splicing regulators Tra and Tra2 are unusually potent activators of pre-mRNA splicing. Sciabica KS, et al. Nucleic Acids Res, 2006. PMID 17135210, Free PMC Article
    4. Omega speckles - a novel class of nuclear speckles containing hnRNPs associated with noncoding hsr-omega RNA in Drosophila. Prasanth KV, et al. J Cell Sci, 2000 Oct. PMID 10984439
    5. The SR protein B52/SRp55 regulates splicing of the period thermosensitive intron and mid-day siesta in Drosophila. Zhang Z, et al. Sci Rep, 2018 Jan 30. PMID 29382842, Free PMC Article

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of alternative mRNA splicing, via spliceosome HMP PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcriptional start site selection at RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SR family splicing factor SC35
    Names
    CG5442-PA
    CG5442-PB
    CG5442-PC
    CG5442-PD
    SC35-PA
    SC35-PB
    SC35-PC
    SC35-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      12431075..12434665 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201865.2 → NP_001188794.1  SR family splicing factor SC35, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188794.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1C547, Q9V3T8, Q9VK86
      Conserved Domains (2) summary
      COG0724
      Location:24 → 100
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12311
      Location:25 → 97
      RRM_SRSF2_SRSF8; RNA recognition motif in serine/arginine-rich splicing factor SRSF2, SRSF8 and similar proteins

    2. NM_001259076.2 → NP_001246005.1  SR family splicing factor SC35, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246005.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1C547, Q9V3T8, Q9VK86
      Conserved Domains (2) summary
      COG0724
      Location:24 → 100
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12311
      Location:25 → 97
      RRM_SRSF2_SRSF8; RNA recognition motif in serine/arginine-rich splicing factor SRSF2, SRSF8 and similar proteins

    3. NM_205967.2 → NP_995689.1  SR family splicing factor SC35, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995689.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTD2

    4. NM_144355.4 → NP_652612.1  SR family splicing factor SC35, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652612.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C1C547, Q9V3T8, Q9VK86
      Related
      FBpp0088838
      Conserved Domains (2) summary
      COG0724
      Location:24 → 100
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12311
      Location:25 → 97
      RRM_SRSF2_SRSF8; RNA recognition motif in serine/arginine-rich splicing factor SRSF2, SRSF8 and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KTD2 Q7KTD2
    Q9V3T8 Q9V3T8

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