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    Tsp Thrombospondin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33941, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tspprovided by FlyBase
    Official Full Name
    Thrombospondinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031850
    Locus tag
    Dmel_CG11326
    See related
    AllianceGenome:FB:FBgn0031850
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11326; CT31613; D-TSP; Dmel\CG11326; DTSP; SP295; tsp; TSP
    Summary
    Enables heparin binding activity. Involved in cell adhesion mediated by integrin and muscle attachment. Located in collagen-containing extracellular matrix and muscle tendon junction. Part of protein-containing complex. Is expressed in several structures, including anlage in statu nascendi; embryonic/larval hypodermal muscle cell; endoderm anlage; epidermis; and head epidermis primordium. Human ortholog(s) of this gene implicated in carpal tunnel syndrome 2; multiple epiphyseal dysplasia 1; osteochondrodysplasia; and pseudoachondroplasia. Orthologous to several human genes including THBS3 (thrombospondin 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See Tsp in Genome Data Viewer
    Location:
    26F7-27A1; 2-22 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6686791..6709086, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6686791..6709086, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Na[+]/H[+] hydrogen exchanger 3 Neighboring gene uncharacterized protein Neighboring gene Adipokinetic hormone receptor Neighboring gene Apoptosis antagonizing transcription factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular evolution of the Thrombospondin superfamily. Tucker RP, et al. Semin Cell Dev Biol, 2024 Mar 1. PMID 37202276
    2. Characterisation of Drosophila thrombospondin defines an early origin of pentameric thrombospondins. Adams JC, et al. J Mol Biol, 2003 Apr 25. PMID 12691755
    3. Loss of thrombospondin reveals a possible role for the extracellular matrix in chordotonal cap cell elongation. Greenblatt Ben-El RT, et al. Int J Dev Biol, 2017. PMID 28621428
    4. A thrombospondin homologue in Drosophila melanogaster: cDNA and protein structure. Adolph KW. Gene, 2001 May 16. PMID 11376949
    5. Thrombospondin expression in myofibers stabilizes muscle membranes. Vanhoutte D, et al. Elife, 2016 Sep 26. PMID 27669143, Free PMC Article

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the conserved transmembrane Drosophila proteoglycan Kon-tiki (Kon, also known as Perdido) interacts with the alphaPS2betaPS integrin (alphaPS2 is encoded by inflated and betaPS by myospheroid) to mediate muscle-tendon adhesion.
      Title: Kon-tiki enhances PS2 integrin adhesion and localizes its ligand, Thrombospondin, in the myotendinous junction.
    2. thrombospondin may have a role with extracellular matrix in chordotonal cap cell elongation in Drosophila
      Title: Loss of thrombospondin reveals a possible role for the extracellular matrix in chordotonal cap cell elongation.
    3. Thrombospondin-mediated adhesion is essential for the formation of the myotendinous junction in Drosophila.
      Title: Thrombospondin-mediated adhesion is essential for the formation of the myotendinous junction in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heparin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell adhesion mediated by integrin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle attachment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in collagen-containing extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in collagen-containing extracellular matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in muscle tendon junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    thrombospondin
    Names
    CG11326-PA
    CG11326-PC
    CG11326-PD
    CG11326-PE
    CG11326-PF
    CG11326-PG
    CG11326-PH
    Tsp-PA
    Tsp-PC
    Tsp-PD
    Tsp-PE
    Tsp-PF
    Tsp-PG
    Tsp-PH

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6686791..6709086 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001144330.2 → NP_001137802.1  thrombospondin, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137802.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q968S4, Q9VM97
      Conserved Domains (9) summary
      smart00179
      Location:343 → 377
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:421 → 457
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00001
      Location:714 → 751
      TSP3; TSP3 repeat_long [structural motif]
      sd00002
      Location:656 → 690
      TSP3; TSP3 repeat_long [structural motif]
      sd00003
      Location:563 → 595
      TSP3_1C; TSP3 repeat_1C [structural motif]
      pfam02412
      Location:656 → 690
      TSP_3; Thrombospondin type 3 repeat
      pfam05735
      Location:841 → 1038
      TSP_C; Thrombospondin C-terminal region
      pfam07645
      Location:477 → 513
      EGF_CA; Calcium-binding EGF domain
      cd16081
      Location:245 → 286
      TSPcc_insect; Coiled coil region of thrombospondin in protostomes

    2. NM_078771.3 → NP_523495.2  thrombospondin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523495.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q968S4, Q9VM97
      Related
      FBpp0078941
      Conserved Domains (9) summary
      smart00179
      Location:343 → 377
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:421 → 457
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00001
      Location:714 → 751
      TSP3; TSP3 repeat_long [structural motif]
      sd00002
      Location:656 → 690
      TSP3; TSP3 repeat_long [structural motif]
      sd00003
      Location:563 → 595
      TSP3_1C; TSP3 repeat_1C [structural motif]
      pfam02412
      Location:656 → 690
      TSP_3; Thrombospondin type 3 repeat
      pfam05735
      Location:841 → 1038
      TSP_C; Thrombospondin C-terminal region
      pfam07645
      Location:477 → 513
      EGF_CA; Calcium-binding EGF domain
      cd16081
      Location:245 → 286
      TSPcc_insect; Coiled coil region of thrombospondin in protostomes

    3. NM_001144331.2 → NP_001137803.1  thrombospondin, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137803.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z030
      Conserved Domains (7) summary
      cd00054
      Location:12 → 48
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00001
      Location:223 → 245
      TSP3; TSP3 repeat_short [structural motif]
      sd00002
      Location:247 → 281
      TSP3; TSP3 repeat_long [structural motif]
      sd00003
      Location:154 → 186
      TSP3_1C; TSP3 repeat_1C [structural motif]
      pfam02412
      Location:247 → 281
      TSP_3; Thrombospondin type 3 repeat
      pfam05735
      Location:432 → 629
      TSP_C; Thrombospondin C-terminal region
      pfam07645
      Location:68 → 104
      EGF_CA; Calcium-binding EGF domain

    4. NM_001273219.1 → NP_001260148.1  thrombospondin, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260148.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7Z030
      Conserved Domains (7) summary
      cd00054
      Location:12 → 48
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      sd00001
      Location:223 → 245
      TSP3; TSP3 repeat_short [structural motif]
      sd00002
      Location:247 → 281
      TSP3; TSP3 repeat_long [structural motif]
      sd00003
      Location:154 → 186
      TSP3_1C; TSP3 repeat_1C [structural motif]
      pfam02412
      Location:247 → 281
      TSP_3; Thrombospondin type 3 repeat
      pfam05735
      Location:432 → 629
      TSP_C; Thrombospondin C-terminal region
      pfam07645
      Location:68 → 104
      EGF_CA; Calcium-binding EGF domain

    5. NM_164703.2 → NP_723204.1  thrombospondin, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723204.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0I9, Q9U3W8
      Related
      FBpp0078940
      Conserved Domains (2) summary
      smart00179
      Location:343 → 377
      EGF_CA; Calcium-binding EGF-like domain
      cd16081
      Location:245 → 286
      TSPcc_insect; Coiled coil region of thrombospondin in protostomes

    6. NM_164702.2 → NP_723203.1  thrombospondin, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723203.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0I9, Q9U3W8
      Related
      FBpp0078942
      Conserved Domains (2) summary
      smart00179
      Location:343 → 377
      EGF_CA; Calcium-binding EGF-like domain
      cd16081
      Location:245 → 286
      TSPcc_insect; Coiled coil region of thrombospondin in protostomes

    7. NM_164704.2 → NP_723205.1  thrombospondin, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723205.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T0I9, Q9U3W8
      Related
      FBpp0078943
      Conserved Domains (2) summary
      smart00179
      Location:343 → 377
      EGF_CA; Calcium-binding EGF-like domain
      cd16081
      Location:245 → 286
      TSPcc_insect; Coiled coil region of thrombospondin in protostomes
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B7Z030 B7Z030
    Q8T0I9 Q8T0I9
    Q968S4 Q968S4
    Q9U3W8 Q9U3W8
    Q9VM97 Q9VM97

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