SNF4Agamma SNF4/AMP-activated protein kinase gamma subunit [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: SNF4Agammaprovided by FlyBase
Official Full Name: SNF4/AMP-activated protein kinase gamma subunitprovided by FlyBase
Primary source: FLYBASE:FBgn0264357
Locus tag: Dmel_CG17299
See related: AllianceGenome:FB:FBgn0264357
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 0050/42; 0127/19; AMPgamma; AMPK; AMPK-gamma; AMPKgamma; anon-WO0118547.338; anon-WO0118547.575; anon-WO0257455.21; CG17299; CG5806; Dmel\CG17299; EP3015b; FBgn0025803; l(3)S005042; l(3)S012719; loe; loeI; snf4; SNF4; SNF4a; SNF4A; SNF4A-gamma; SNF4Ag; SNF4gamma; Snfg; Snfgamma
Summary: Predicted to enable AMP binding activity; protein kinase binding activity; and protein kinase regulator activity. Involved in several processes, including behavioral response to starvation; cholesterol homeostasis; and sequestering of triglyceride. Located in cytoplasm and nucleus. Is expressed in several structures, including adult head; adult ventral nerve cord; anterior endoderm; embryonic/larval midgut primordium; and larval midline neurons. Used to study neurodegenerative disease. Human ortholog(s) of this gene implicated in Wolff-Parkinson-White syndrome; glycogen storage disease; hypertrophic cardiomyopathy 6; and lethal congenital glycogen storage disease of heart. Orthologous to several human genes including PRKAG2 (protein kinase AMP-activated non-catalytic subunit gamma 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 93C1-93C5; 3-71 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (21140739..21214269)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (16966461..17039991)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study finds that AMP-activated protein kinase (SNF4Agamma) regulates circadian rhythm by affecting CLOCK in drosophila. Study shows that the AMPKgamma subunit of AMPK, a central regulator of cellular metabolism, copurifies with the CLK/CYC complex in Drosophila S2 cells.
Title: AMP-Activated Protein Kinase Regulates Circadian Rhythm by Affecting CLOCK in Drosophila.
AMPK gamma and alpha mutants altered lipid metabolism and showed persistent starvation behaviors.
Title: Altered metabolism and persistent starvation behaviors caused by reduced AMPK function in Drosophila.
Results demonstrate that SNF4Agamma has an essential role in the regulation of autophagy in Drosophila larval fat body cells.
Title: SNF4Agamma, the Drosophila AMPK gamma subunit is required for regulation of developmental and stress-induced autophagy.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0584 (e-PCR)
- UniSTS:74287

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables AMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in behavioral response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to glucose starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cholesterol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of gluconeogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of carbon utilization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sequestering of triglyceride	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of nucleotide-activated protein kinase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: SNF4/AMP-activated protein kinase gamma subunit

Names: AMP-activated protein kinase gamma subunit; CG17299-PA; CG17299-PB; CG17299-PC; CG17299-PE; CG17299-PF; CG17299-PG; CG17299-PI; CG17299-PJ; CG17299-PK; CG17299-PM; CG17299-PN; CG17299-PO; CG17299-PP; CG17299-PQ; CG17299-PR; CG17299-PS; SNF4/AMP-activated protein kinase gamma; SNF4Agamma-PA; SNF4Agamma-PB; SNF4Agamma-PC; SNF4Agamma-PE; SNF4Agamma-PF; SNF4Agamma-PG; SNF4Agamma-PI; SNF4Agamma-PJ; SNF4Agamma-PK; SNF4Agamma-PM; SNF4Agamma-PN; SNF4Agamma-PO; SNF4Agamma-PP; SNF4Agamma-PQ; SNF4Agamma-PR; SNF4Agamma-PS; lethal (3) S005042; lethal (3) S012719; lochrig; loechrig

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

21140739..21214269

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_169946.2 → NP_732594.1 SNF4/AMP-activated protein kinase gamma subunit, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732594.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7JQX9

Related

FBpp0083421

Conserved Domains (3) summary

COG0517
Location:570 → 688

CBS; CBS domain [Signal transduction mechanisms]

cd04618
Location:488 → 616

CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

cd04641
Location:644 → 762

CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
NM_080509.3 → NP_536757.2 SNF4/AMP-activated protein kinase gamma subunit, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_536757.2

Status: REVIEWED

UniProtKB/TrEMBL

Q7JQX9

Related

FBpp0083422

Conserved Domains (3) summary

COG0517
Location:570 → 688

CBS; CBS domain [Signal transduction mechanisms]

cd04618
Location:488 → 616

CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

cd04641
Location:644 → 762

CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
NM_001170200.2 → NP_001163671.1 SNF4/AMP-activated protein kinase gamma subunit, isoform R [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163671.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8SZS7, Q9VDD2

Conserved Domains (3) summary

COG0517
Location:1023 → 1141

CBS; CBS domain [Signal transduction mechanisms]

cd04618
Location:941 → 1069

CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

cd04641
Location:1097 → 1215

CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
NM_169947.3 → NP_732598.1 SNF4/AMP-activated protein kinase gamma subunit, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732598.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8SZS7, Q9VDD2

Related

FBpp0083423

Conserved Domains (3) summary

COG0517
Location:1023 → 1141

CBS; CBS domain [Signal transduction mechanisms]

cd04618
Location:941 → 1069

CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

cd04641
Location:1097 → 1215

CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
NM_001170201.2 → NP_001163672.1 SNF4/AMP-activated protein kinase gamma subunit, isoform S [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163672.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8SZS7, Q9VDD2

Conserved Domains (3) summary

COG0517
Location:1023 → 1141

CBS; CBS domain [Signal transduction mechanisms]

cd04618
Location:941 → 1069

CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

cd04641
Location:1097 → 1215

CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
NM_001104385.2 → NP_001097855.1 SNF4/AMP-activated protein kinase gamma subunit, isoform N [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097855.1

Status: REVIEWED

UniProtKB/TrEMBL

A1A6Y3, A1A703

Conserved Domains (3) summary

COG0517
Location:237 → 355

CBS; CBS domain [Signal transduction mechanisms]

cd04618
Location:155 → 283

CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

cd04641
Location:311 → 429

CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
NM_001104384.3 → NP_001097854.1 SNF4/AMP-activated protein kinase gamma subunit, isoform M [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097854.1

Status: REVIEWED

UniProtKB/TrEMBL

A1A6Y3, A1A703

Conserved Domains (3) summary

COG0517
Location:237 → 355

CBS; CBS domain [Signal transduction mechanisms]

cd04618
Location:155 → 283

CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

cd04641
Location:311 → 429

CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
NM_001043271.3 → NP_001036736.2 SNF4/AMP-activated protein kinase gamma subunit, isoform O [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036736.2

Status: REVIEWED

UniProtKB/TrEMBL

A1A6Y3, A1A703

Conserved Domains (3) summary

COG0517
Location:237 → 355

CBS; CBS domain [Signal transduction mechanisms]

cd04618
Location:155 → 283

CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

cd04641
Location:311 → 429

CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
NM_001170198.2 → NP_001163669.1 SNF4/AMP-activated protein kinase gamma subunit, isoform P [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163669.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8I0B2, Q8SXT8

Conserved Domains (3) summary

COG0517
Location:529 → 647

CBS; CBS domain [Signal transduction mechanisms]

cd04618
Location:447 → 575

CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

cd04641
Location:603 → 721

CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
NM_169948.3 → NP_732599.1 SNF4/AMP-activated protein kinase gamma subunit, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732599.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8I0B2, Q8SXT8

Related

FBpp0083424

Conserved Domains (3) summary

COG0517
Location:529 → 647

CBS; CBS domain [Signal transduction mechanisms]

cd04618
Location:447 → 575

CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

cd04641
Location:603 → 721

CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
NM_001043273.3 → NP_001036738.1 SNF4/AMP-activated protein kinase gamma subunit, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036738.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8I0B2, Q8SXT8

Conserved Domains (3) summary

COG0517
Location:529 → 647

CBS; CBS domain [Signal transduction mechanisms]

cd04618
Location:447 → 575

CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

cd04641
Location:603 → 721

CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
NM_169949.3 → NP_732600.1 SNF4/AMP-activated protein kinase gamma subunit, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732600.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8I0B2, Q8SXT8

Related

FBpp0083425

Conserved Domains (3) summary

COG0517
Location:529 → 647

CBS; CBS domain [Signal transduction mechanisms]

cd04618
Location:447 → 575

CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

cd04641
Location:603 → 721

CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
NM_001170199.2 → NP_001163670.1 SNF4/AMP-activated protein kinase gamma subunit, isoform Q [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163670.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8I0B2, Q8SXT8

Conserved Domains (3) summary

COG0517
Location:529 → 647

CBS; CBS domain [Signal transduction mechanisms]

cd04618
Location:447 → 575

CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

cd04641
Location:603 → 721

CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
NM_001043272.2 → NP_001036737.1 SNF4/AMP-activated protein kinase gamma subunit, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036737.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8I0B2, Q8SXT8

Conserved Domains (3) summary

COG0517
Location:529 → 647

CBS; CBS domain [Signal transduction mechanisms]

cd04618
Location:447 → 575

CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

cd04641
Location:603 → 721

CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
NM_169950.3 → NP_732601.1 SNF4/AMP-activated protein kinase gamma subunit, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732601.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8I0A1, Q8I0K6

Related

FBpp0083427

Conserved Domains (3) summary

COG0517
Location:437 → 555

CBS; CBS domain [Signal transduction mechanisms]

cd04618
Location:355 → 483

CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

cd04641
Location:511 → 629

CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...
NM_001043274.2 → NP_001036739.1 SNF4/AMP-activated protein kinase gamma subunit, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036739.1

Status: REVIEWED

UniProtKB/TrEMBL

Q0KI34, Q8IGX0

Conserved Domains (3) summary

COG0517
Location:161 → 279

CBS; CBS domain [Signal transduction mechanisms]

cd04618
Location:79 → 207

CBS_pair_5; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

cd04641
Location:235 → 353

CBS_pair_28; The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called ...

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
A1A703		A1A703
O96613		O96613
Q0KI34		Q0KI34
Q7JQX9		Q7JQX9
Q7KNS9		Q7KNS9
Q8I0A1		Q8I0A1
Q8I0B2		Q8I0B2
Q8I0K6		Q8I0K6
Q8IGX0		Q8IGX0
Q8SXT8		Q8SXT8
Q9VDD2		Q9VDD2