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    Eci2 enoyl-Coenzyme A delta isomerase 2 [ Mus musculus (house mouse) ]

    Gene ID: 23986, updated on 3-Nov-2024

    Summary

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    Official Symbol
    Eci2provided by MGI
    Official Full Name
    enoyl-Coenzyme A delta isomerase 2provided by MGI
    Primary source
    MGI:MGI:1346064
    See related
    Ensembl:ENSMUSG00000021417 AllianceGenome:MGI:1346064
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Drs1; Peci; Acbd2; Hca88
    Summary
    Enables delta(3)-delta(2)-enoyl-CoA isomerase activity. Predicted to be involved in fatty acid beta-oxidation. Located in mitochondrion and peroxisome. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human ECI2 (enoyl-CoA delta isomerase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 30.7), liver adult (RPKM 24.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Eci2 in Genome Data Viewer
    Location:
    13 A3.3; 13 14.23 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (35161731..35211098, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (34977748..35027115, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene testis expressed 56 Neighboring gene STARR-seq mESC enhancer starr_34165 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene enoyl-Coenzyme A delta isomerase 3 Neighboring gene predicted gene, 16984 Neighboring gene STARR-seq mESC enhancer starr_34167 Neighboring gene STARR-seq mESC enhancer starr_34168 Neighboring gene predicted gene, 46408 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:35127596-35127929 Neighboring gene STARR-seq mESC enhancer starr_34169 Neighboring gene predicted gene, 40910 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:35221416-35221651 Neighboring gene STARR-positive B cell enhancer mm9_chr13:35223226-35223527 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:35223796-35223979 Neighboring gene STARR-seq mESC enhancer starr_34170 Neighboring gene RIKEN cDNA 4930529N20 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of PECI, a novel monofunctional Delta(3), Delta(2)-enoyl-CoA isomerase of mammalian peroxisomes. Geisbrecht BV, et al. J Biol Chem, 1999 Jul 30. PMID 10419495
    2. Identification and characterization of Eci3, a murine kidney-specific Δ3,Δ2-enoyl-CoA isomerase. van Weeghel M, et al. FASEB J, 2014 Mar. PMID 24344334
    3. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, et al. J Biol Chem, 2004 Jan 2. PMID 14561759
    4. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Kim SC, et al. Mol Cell, 2006 Aug. PMID 16916647
    5. The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease. Willnow T, et al. Organogenesis, 2005 Apr. PMID 19521566, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables delta(3)-delta(2)-enoyl-CoA isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables delta(3)-delta(2)-enoyl-CoA isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables delta(3)-delta(2)-enoyl-CoA isomerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables delta(3)-delta(2)-enoyl-CoA isomerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables fatty-acyl-CoA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables intramolecular oxidoreductase activity, transposing C=C bonds ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid beta-oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid beta-oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fatty acid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fatty acid catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisomal matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisomal matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisomal matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    enoyl-CoA delta isomerase 2
    Names
    D3,D2-enoyl-CoA isomerase
    delta(3),delta(2)-enoyl-CoA isomerase
    dodecenoyl-CoA isomerase
    enoyl-CoA delta isomerase 2, mitochondrial
    peroxisomal 3,2-trans-enoyl-CoA isomerase
    peroxisomal delta3, delta2-enoyl-Coenzyme A isomerase
    NP_001103801.1
    NP_035998.2
    XP_006516736.1
    XP_006516737.1
    XP_006516738.1
    XP_006516739.1
    XP_006516740.1
    XP_030103124.1
    XP_030103125.1
    XP_030103126.1
    XP_036013943.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110331.1 → NP_001103801.1  enoyl-CoA delta isomerase 2 isoform a

      See identical proteins and their annotated locations for NP_001103801.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AK009478, BQ176032, BY037058
      Consensus CDS
      CCDS49234.1
      UniProtKB/Swiss-Prot
      Q99M61, Q9D785, Q9WUR2
      UniProtKB/TrEMBL
      Q3TCD4
      Related
      ENSMUSP00000131735.2, ENSMUST00000171229.8
      Conserved Domains (2) summary
      pfam00887
      Location:38 → 113
      ACBP; Acyl CoA binding protein
      cl23717
      Location:139 → 389
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

    2. NM_011868.3 → NP_035998.2  enoyl-CoA delta isomerase 2 isoform b

      See identical proteins and their annotated locations for NP_035998.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream initiation codon, compared to variant 1. The resulting protein (isoform b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.
      Source sequence(s)
      AK009478, BQ176032, BY037058, CX242291
      Consensus CDS
      CCDS26450.1
      UniProtKB/TrEMBL
      Q3TCD4
      Related
      ENSMUSP00000021854.7, ENSMUST00000021854.14
      Conserved Domains (2) summary
      pfam00887
      Location:5 → 80
      ACBP; Acyl CoA binding protein
      cl23717
      Location:106 → 356
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

    RNA

    1. NR_073427.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 5' exon structure compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK009478, BQ176032, BY037058, BY238570
      Related
      ENSMUST00000110251.9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      35161731..35211098 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516677.2 → XP_006516740.1  enoyl-CoA delta isomerase 2 isoform X1

      See identical proteins and their annotated locations for XP_006516740.1

      UniProtKB/TrEMBL
      Q3TCD4
      Conserved Domains (2) summary
      pfam00887
      Location:5 → 80
      ACBP; Acyl CoA binding protein
      cl23717
      Location:106 → 356
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

    2. XM_006516676.4 → XP_006516739.1  enoyl-CoA delta isomerase 2 isoform X1

      See identical proteins and their annotated locations for XP_006516739.1

      UniProtKB/TrEMBL
      Q3TCD4
      Conserved Domains (2) summary
      pfam00887
      Location:5 → 80
      ACBP; Acyl CoA binding protein
      cl23717
      Location:106 → 356
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

    3. XM_030247264.1 → XP_030103124.1  enoyl-CoA delta isomerase 2 isoform X1

      UniProtKB/TrEMBL
      Q3TCD4
      Conserved Domains (2) summary
      pfam00887
      Location:5 → 80
      ACBP; Acyl CoA binding protein
      cl23717
      Location:106 → 356
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

    4. XM_006516674.4 → XP_006516737.1  enoyl-CoA delta isomerase 2 isoform X1

      See identical proteins and their annotated locations for XP_006516737.1

      UniProtKB/TrEMBL
      Q3TCD4
      Related
      ENSMUSP00000137411.2, ENSMUST00000178421.8
      Conserved Domains (2) summary
      pfam00887
      Location:5 → 80
      ACBP; Acyl CoA binding protein
      cl23717
      Location:106 → 356
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

    5. XM_006516675.3 → XP_006516738.1  enoyl-CoA delta isomerase 2 isoform X1

      See identical proteins and their annotated locations for XP_006516738.1

      UniProtKB/TrEMBL
      Q3TCD4
      Conserved Domains (2) summary
      pfam00887
      Location:5 → 80
      ACBP; Acyl CoA binding protein
      cl23717
      Location:106 → 356
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

    6. XM_030247265.2 → XP_030103125.1  enoyl-CoA delta isomerase 2 isoform X2

      Conserved Domains (1) summary
      cl23717
      Location:1 → 224
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

    7. XM_006516673.4 → XP_006516736.1  enoyl-CoA delta isomerase 2 isoform X1

      See identical proteins and their annotated locations for XP_006516736.1

      UniProtKB/TrEMBL
      Q3TCD4
      Conserved Domains (2) summary
      pfam00887
      Location:5 → 80
      ACBP; Acyl CoA binding protein
      cl23717
      Location:106 → 356
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

    8. XM_036158050.1 → XP_036013943.1  enoyl-CoA delta isomerase 2 isoform X2

      Conserved Domains (1) summary
      cl23717
      Location:1 → 224
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

    9. XM_030247266.2 → XP_030103126.1  enoyl-CoA delta isomerase 2 isoform X2

      Conserved Domains (1) summary
      cl23717
      Location:1 → 224
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001110332.1: Suppressed sequence

      Description
      NM_001110332.1: This RefSeq was permanently suppressed because it is now thought that this transcript does not encode a protein.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WUR2.2 GenPept UniProtKB/Swiss-Prot:Q9WUR2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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