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    USP4 ubiquitin specific peptidase 4 [ Pan troglodytes (chimpanzee) ]

    Gene ID: 460367, updated on 10-Oct-2024

    Summary

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    Official Symbol
    USP4provided by VGNC
    Official Full Name
    ubiquitin specific peptidase 4provided by VGNC
    Primary source
    VGNC:VGNC:10047
    Locus tag
    CK820_G0005107
    See related
    Ensembl:ENSPTRG00000014920
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
    Orthologs
    human mouse all
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    Genomic context

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    See USP4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 2 NC_086015.1 (53308559..53372728, complement)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 3 NC_072401.1 (53308226..53371996, complement)

    Chromosome 2 - NC_086015.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134809564 Neighboring gene chromosome 3 C3orf62 homolog Neighboring gene glutathione peroxidase 1 Neighboring gene ras homolog family member A Neighboring gene T cell leukemia translocation altered

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Major chimpanzee-specific structural changes in sperm development-associated genes. Kim RN, et al. Funct Integr Genomics, 2011 Sep. PMID 21484476
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in ciliary basal body IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 4
    Names
    ubiquitin specific peptidase 4 (proto-oncogene)
    ubiquitin specific protease, proto-oncogene
    XP_001163407.1
    XP_001163445.1
    XP_003309895.1
    XP_009443766.1
    XP_016796582.1
    XP_016796583.1
    XP_016796584.1
    XP_054537843.1
    XP_054537844.1
    XP_063662846.1
    XP_063662847.1
    XP_063662848.1
    XP_063662849.1
    XP_063662850.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_086015.1 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      53308559..53372728 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001163445.8 → XP_001163445.1  ubiquitin carboxyl-terminal hydrolase 4 isoform X1

      See identical proteins and their annotated locations for XP_001163445.1

      UniProtKB/TrEMBL
      A0A2I3S146, A0A2J8P9D9, A0A6D2WN86, H2QML3
      Related
      ENSPTRP00000025757.3
      Conserved Domains (1) summary
      cl02553
      Location:35 → 922
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

    2. XM_001163407.8 → XP_001163407.1  ubiquitin carboxyl-terminal hydrolase 4 isoform X2

      See identical proteins and their annotated locations for XP_001163407.1

      UniProtKB/TrEMBL
      A0A2I3SJM5, A0A2J8P9F2, A0A6D2XNE5, K7CG48
      Related
      ENSPTRP00000092578.1
      Conserved Domains (1) summary
      cl02553
      Location:35 → 875
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

    3. XM_009445491.5 → XP_009443766.1  ubiquitin carboxyl-terminal hydrolase 4 isoform X4

      See identical proteins and their annotated locations for XP_009443766.1

      UniProtKB/TrEMBL
      A0A2I3S146
      Conserved Domains (4) summary
      smart00695
      Location:27 → 125
      DUSP; Domain in ubiquitin-specific proteases
      cl02553
      Location:775 → 881
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam14533
      Location:504 → 567
      USP7_C2; Ubiquitin-specific protease C-terminal
      pfam14836
      Location:139 → 226
      Ubiquitin_3; Ubiquitin-like domain

    4. XM_016941094.4 → XP_016796583.1  ubiquitin carboxyl-terminal hydrolase 4 isoform X8

      UniProtKB/TrEMBL
      A0A2I3SJM5

    5. XM_063806778.1 → XP_063662848.1  ubiquitin carboxyl-terminal hydrolase 4 isoform X9

    6. XM_054681868.2 → XP_054537843.1  ubiquitin carboxyl-terminal hydrolase 4 isoform X5

    7. XM_063806776.1 → XP_063662846.1  ubiquitin carboxyl-terminal hydrolase 4 isoform X6

    8. XM_063806777.1 → XP_063662847.1  ubiquitin carboxyl-terminal hydrolase 4 isoform X7

    9. XM_016941093.4 → XP_016796582.1  ubiquitin carboxyl-terminal hydrolase 4 isoform X3

      UniProtKB/TrEMBL
      A0A2I3S146
      Conserved Domains (1) summary
      COG5560
      Location:35 → 847
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]

    10. XM_063806779.1 → XP_063662849.1  ubiquitin carboxyl-terminal hydrolase 4 isoform X11

    11. XM_054681869.2 → XP_054537844.1  ubiquitin carboxyl-terminal hydrolase 4 isoform X10

    12. XM_003309847.7 → XP_003309895.1  ubiquitin carboxyl-terminal hydrolase 4 isoform X12

      UniProtKB/TrEMBL
      A0A2I3TUX3, A0A2J8P9E7, A0A6D2WBT3
      Related
      ENSPTRP00000093080.1
      Conserved Domains (3) summary
      smart00695
      Location:27 → 125
      DUSP; Domain in ubiquitin-specific proteases
      pfam14836
      Location:139 → 226
      Ubiquitin_3; Ubiquitin-like domain
      cl25602
      Location:226 → 308
      DUF3552; Domain of unknown function (DUF3552)

    13. XM_016941095.4 → XP_016796584.1  ubiquitin carboxyl-terminal hydrolase 4 isoform X13

    14. XM_063806780.1 → XP_063662850.1  ubiquitin carboxyl-terminal hydrolase 4 isoform X13

    Nucleotide Protein
    Heading Accession and Version

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