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    BDNF brain derived neurotrophic factor [ Homo sapiens (human) ]

    Gene ID: 627, updated on 2-Nov-2024

    Summary

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    Official Symbol
    BDNFprovided by HGNC
    Official Full Name
    brain derived neurotrophic factorprovided by HGNC
    Primary source
    HGNC:HGNC:1033
    See related
    Ensembl:ENSG00000176697 MIM:113505; AllianceGenome:HGNC:1033
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ANON2; BULN2
    Summary
    This gene encodes a member of the nerve growth factor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. Binding of this protein to its cognate receptor promotes neuronal survival in the adult brain. Expression of this gene is reduced in Alzheimer's, Parkinson's, and Huntington's disease patients. This gene may play a role in the regulation of the stress response and in the biology of mood disorders. [provided by RefSeq, Nov 2015]
    Expression
    Biased expression in brain (RPKM 3.0), lung (RPKM 1.2) and 11 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See BDNF in Genome Data Viewer
    Location:
    11p14.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (27654893..27722030, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (27795301..27862460, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (27676440..27743577, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene BDNF antisense RNA Neighboring gene ribosomal protein S25 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 104 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:27650686-27651472 Neighboring gene long intergenic non-protein coding RNA 678 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:27653431-27654320 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:27655211-27656100 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:27656101-27656990 Neighboring gene Sharpr-MPRA regulatory region 8127 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:27708921-27709828 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:27709829-27710734 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:27743527-27744035 Neighboring gene uncharacterized LOC124902652 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:27762065-27762756 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:27817576-27818442 Neighboring gene CBX3 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Association between a functional single nucleotide polymorphism in the brain-derived neurotrophic factor gene and risk of child asthma. Wang JY, et al. Genet Mol Res, 2015 Dec 8. PMID 26662416
    2. Higher brain BDNF gene expression is associated with slower cognitive decline in older adults. Buchman AS, et al. Neurology, 2016 Feb 23. PMID 26819457, Free PMC Article
    3. Val66Met BDNF polymorphism is associated with Parkinson's disease cognitive impairment. Altmann V, et al. Neurosci Lett, 2016 Feb 26. PMID 26806863
    4. Interaction between different sports branches such as taekwondo, box, athletes and serum brain derived neurotrophic factor levels. Oztasyonar Y. J Sports Med Phys Fitness, 2017 Apr. PMID 26796075
    5. BDNF val66met polymorphism and depressive disorders in patients with acute coronary syndrome. Kang HJ, et al. J Affect Disord, 2016 Apr. PMID 26795846

    See all (1000) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Brain-Derived Neurotrophic Factor rs6265 polymorphism is associated with severe cancer-related fatigue and neuropathic pain in female cancer survivors.
      Title: Brain-Derived Neurotrophic Factor rs6265 polymorphism is associated with severe cancer-related fatigue and neuropathic pain in female cancer survivors.
    2. Association between the Val66Met (rs6265) polymorphism of the brain-derived neurotrophic factor (BDNF) gene, BDNF protein level in the blood and the risk of developing early-onset Parkinson's disease.
      Title: Association between the Val66Met (rs6265) polymorphism of the brain-derived neurotrophic factor (BDNF) gene, BDNF protein level in the blood and the risk of developing early‑onset Parkinson's disease.
    3. APOExBDNF Interaction and Poorer Cognitive Outcomes Among Veterans With Mild Traumatic Brain Injury: An Exploratory Study.
      Title: APOE×BDNF Interaction and Poorer Cognitive Outcomes Among Veterans With Mild Traumatic Brain Injury: An Exploratory Study.
    4. Skin keratinocyte-derived SIRT1 and BDNF modulate mechanical allodynia in mouse models of diabetic neuropathy.
      Title: Skin keratinocyte-derived SIRT1 and BDNF modulate mechanical allodynia in mouse models of diabetic neuropathy.
    5. NRN1 epistasis with BDNF and CACNA1C: mediation effects on symptom severity through neuroanatomical changes in schizophrenia.
      Title: NRN1 epistasis with BDNF and CACNA1C: mediation effects on symptom severity through neuroanatomical changes in schizophrenia.
    6. Assessment of brain-derived neurotrophic factor and irisin concentration in children with chronic kidney disease: a pilot study.
      Title: Assessment of brain-derived neurotrophic factor and irisin concentration in children with chronic kidney disease: a pilot study.
    7. Brain-derived neurotrophic factor G196A (rs6265) gene polymorphism increases Turner syndrome susceptibility.
      Title: Brain-derived neurotrophic factor G196A (rs6265) gene polymorphism increases Turner syndrome susceptibility.
    8. The impact of flavonoids and BDNF on neurogenic process in various physiological/pathological conditions including ischemic insults: a narrative review.
      Title: The impact of flavonoids and BDNF on neurogenic process in various physiological/pathological conditions including ischemic insults: a narrative review.
    9. BDNF Val66Met moderates episodic memory decline and tau biomarker increases in early sporadic Alzheimer's disease.
      Title: BDNF Val66Met moderates episodic memory decline and tau biomarker increases in early sporadic Alzheimer's disease.
    10. Association of BDNF polymorphism with gestational diabetes mellitus risk: a novel insight into genetic predisposition.
      Title: Association of BDNF polymorphism with gestational diabetes mellitus risk: a novel insight into genetic predisposition.
    Submit: New GeneRIF Correction See all GeneRIFs (2319)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
    EBI GWAS Catalog
    Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations.
    EBI GWAS Catalog
    Genome wide association study identifies KCNMA1 contributing to human obesity.
    EBI GWAS Catalog
    Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.
    EBI GWAS Catalog
    Genome-wide meta-analyses identify multiple loci associated with smoking behavior.
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.
    EBI GWAS Catalog
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Co-exposure of human fetal neurons to brain-derived neurotrophic factor (BDNF) and HIV-1 gp120 leads to a dose-dependent increase in BDNF-induced somatostatin (SRIF) production PubMed
    Tat tat The gene expression of brain-derived neurotrophic factor is significantly upregulated in both clade B and clade C Tat treated SK-N-MC cells PubMed
    tat Human BDNF is protective to neuroblastoma cells exposed to HIV-1 Tat PubMed
    tat HIV-1 Tat increases proapoptotic proBDNF and decreases the mature BDNF protein in hippocampal neurons PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC34632

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nerve growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in brain-derived neurotrophic factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in collateral sprouting IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of apoptotic signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of myotube differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of neuron apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nerve development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nerve growth factor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nervous system development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in neuron projection morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of brain-derived neurotrophic factor receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of collateral sprouting IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of synapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of protein localization to cell surface TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in synapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    brain-derived neurotrophic factor
    Names
    abrineurin
    neurotrophin

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011794.2 RefSeqGene

      Range
      26575..72137
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001143805.1 → NP_001137277.1  brain-derived neurotrophic factor isoform a preproprotein

      See identical proteins and their annotated locations for NP_001137277.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), also known as IIa or BDNF2A, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
      Source sequence(s)
      EF674517
      Consensus CDS
      CCDS7866.1
      UniProtKB/Swiss-Prot
      A7LA85, A7LA92, D3DQZ2, P23560, Q598Q1, Q6DN19, Q6YNR2, Q6YNR3, Q9BYY7, Q9UC24
      UniProtKB/TrEMBL
      A0A0E3SU01, A0A0S2Z3E7
      Related
      ENSP00000432035.1, ENST00000525950.5
      Conserved Domains (1) summary
      smart00140
      Location:133 → 240
      NGF; Nerve growth factor (NGF or beta-NGF)

    2. NM_001143806.1 → NP_001137278.1  brain-derived neurotrophic factor isoform a preproprotein

      See identical proteins and their annotated locations for NP_001137278.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), also known as IIb or BDNF2B, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
      Source sequence(s)
      EF674518
      Consensus CDS
      CCDS7866.1
      UniProtKB/Swiss-Prot
      A7LA85, A7LA92, D3DQZ2, P23560, Q598Q1, Q6DN19, Q6YNR2, Q6YNR3, Q9BYY7, Q9UC24
      UniProtKB/TrEMBL
      A0A0E3SU01, A0A0S2Z3E7
      Related
      ENSP00000379302.3, ENST00000395978.7
      Conserved Domains (1) summary
      smart00140
      Location:133 → 240
      NGF; Nerve growth factor (NGF or beta-NGF)

    3. NM_001143807.2 → NP_001137279.1  brain-derived neurotrophic factor isoform a preproprotein

      See identical proteins and their annotated locations for NP_001137279.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), also known as III or BDNF3, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
      Source sequence(s)
      AC104563, KF459669
      Consensus CDS
      CCDS7866.1
      UniProtKB/Swiss-Prot
      A7LA85, A7LA92, D3DQZ2, P23560, Q598Q1, Q6DN19, Q6YNR2, Q6YNR3, Q9BYY7, Q9UC24
      UniProtKB/TrEMBL
      A0A0E3SU01, A0A0S2Z3E7
      Related
      ENSP00000435805.1, ENST00000532997.5
      Conserved Domains (1) summary
      smart00140
      Location:133 → 240
      NGF; Nerve growth factor (NGF or beta-NGF)

    4. NM_001143808.2 → NP_001137280.1  brain-derived neurotrophic factor isoform a preproprotein

      See identical proteins and their annotated locations for NP_001137280.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), also known as Va, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
      Source sequence(s)
      AC104563, KF459669
      Consensus CDS
      CCDS7866.1
      UniProtKB/Swiss-Prot
      A7LA85, A7LA92, D3DQZ2, P23560, Q598Q1, Q6DN19, Q6YNR2, Q6YNR3, Q9BYY7, Q9UC24
      UniProtKB/TrEMBL
      A0A0E3SU01, A0A0S2Z3E7
      Related
      ENSP00000379307.3, ENST00000395983.7
      Conserved Domains (1) summary
      smart00140
      Location:133 → 240
      NGF; Nerve growth factor (NGF or beta-NGF)

    5. NM_001143809.2 → NP_001137281.1  brain-derived neurotrophic factor isoform d precursor

      See identical proteins and their annotated locations for NP_001137281.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), also known as Vb, represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (d) contains a longer N-terminus and lacks a predicted signal peptide compared to isoform a.
      Source sequence(s)
      AC104563, KF459669
      UniProtKB/Swiss-Prot
      P23560
      Conserved Domains (1) summary
      smart00140
      Location:162 → 269
      NGF; Nerve growth factor (NGF or beta-NGF)

    6. NM_001143810.2 → NP_001137282.1  brain-derived neurotrophic factor isoform e

      See identical proteins and their annotated locations for NP_001137282.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18), also known as V-VIII, represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (e) contains a longer N-terminus and lacks a predicted signal peptide compared to isoform a.
      Source sequence(s)
      AC104563, KF455346, KF459669
      Consensus CDS
      CCDS44558.1
      UniProtKB/Swiss-Prot
      P23560
      Related
      ENSP00000414303.1, ENST00000438929.5
      Conserved Domains (1) summary
      smart00140
      Location:215 → 322
      NGF; Nerve growth factor (NGF or beta-NGF)

    7. NM_001143811.2 → NP_001137283.1  brain-derived neurotrophic factor isoform a preproprotein

      See identical proteins and their annotated locations for NP_001137283.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), also known as V-VIII-VIIIh, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
      Source sequence(s)
      AC104563, KF455346, KF459669
      Consensus CDS
      CCDS7866.1
      UniProtKB/Swiss-Prot
      A7LA85, A7LA92, D3DQZ2, P23560, Q598Q1, Q6DN19, Q6YNR2, Q6YNR3, Q9BYY7, Q9UC24
      UniProtKB/TrEMBL
      A0A0E3SU01, A0A0S2Z3E7
      Conserved Domains (1) summary
      smart00140
      Location:133 → 240
      NGF; Nerve growth factor (NGF or beta-NGF)

    8. NM_001143812.2 → NP_001137284.1  brain-derived neurotrophic factor isoform a preproprotein

      See identical proteins and their annotated locations for NP_001137284.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), also known as Vh, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
      Source sequence(s)
      AC104563, KF459669
      Consensus CDS
      CCDS7866.1
      UniProtKB/Swiss-Prot
      A7LA85, A7LA92, D3DQZ2, P23560, Q598Q1, Q6DN19, Q6YNR2, Q6YNR3, Q9BYY7, Q9UC24
      UniProtKB/TrEMBL
      A0A0E3SU01, A0A0S2Z3E7
      Related
      ENSP00000435564.1, ENST00000530861.5
      Conserved Domains (1) summary
      smart00140
      Location:133 → 240
      NGF; Nerve growth factor (NGF or beta-NGF)

    9. NM_001143813.2 → NP_001137285.1  brain-derived neurotrophic factor isoform a preproprotein

      See identical proteins and their annotated locations for NP_001137285.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), also known as VIa, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
      Source sequence(s)
      AC104563, KF459669
      Consensus CDS
      CCDS7866.1
      UniProtKB/Swiss-Prot
      A7LA85, A7LA92, D3DQZ2, P23560, Q598Q1, Q6DN19, Q6YNR2, Q6YNR3, Q9BYY7, Q9UC24
      UniProtKB/TrEMBL
      A0A0E3SU01, A0A0S2Z3E7
      Related
      ENSP00000432376.1, ENST00000533246.5
      Conserved Domains (1) summary
      smart00140
      Location:133 → 240
      NGF; Nerve growth factor (NGF or beta-NGF)

    10. NM_001143814.2 → NP_001137286.1  brain-derived neurotrophic factor isoform a preproprotein

      See identical proteins and their annotated locations for NP_001137286.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), also known as VIb-IXbd, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
      Source sequence(s)
      AC104563, KF459669
      Consensus CDS
      CCDS7866.1
      UniProtKB/Swiss-Prot
      A7LA85, A7LA92, D3DQZ2, P23560, Q598Q1, Q6DN19, Q6YNR2, Q6YNR3, Q9BYY7, Q9UC24
      UniProtKB/TrEMBL
      A0A0E3SU01, A0A0S2Z3E7
      Related
      ENSP00000400502.1, ENST00000418212.5
      Conserved Domains (1) summary
      smart00140
      Location:133 → 240
      NGF; Nerve growth factor (NGF or beta-NGF)

    11. NM_001143816.2 → NP_001137288.1  brain-derived neurotrophic factor isoform a preproprotein

      See identical proteins and their annotated locations for NP_001137288.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), also known as IXabd, differs in the 5' UTR compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
      Source sequence(s)
      AC104563, KF459669
      Consensus CDS
      CCDS7866.1
      UniProtKB/Swiss-Prot
      A7LA85, A7LA92, D3DQZ2, P23560, Q598Q1, Q6DN19, Q6YNR2, Q6YNR3, Q9BYY7, Q9UC24
      UniProtKB/TrEMBL
      A0A0E3SU01, A0A0S2Z3E7
      Related
      ENSP00000389345.2, ENST00000439476.6
      Conserved Domains (1) summary
      smart00140
      Location:133 → 240
      NGF; Nerve growth factor (NGF or beta-NGF)

    12. NM_001709.5 → NP_001700.2  brain-derived neurotrophic factor isoform a preproprotein

      See identical proteins and their annotated locations for NP_001700.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), also known as VIb or BDNF5, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
      Source sequence(s)
      AC104563, KF459669
      Consensus CDS
      CCDS7866.1
      UniProtKB/Swiss-Prot
      A7LA85, A7LA92, D3DQZ2, P23560, Q598Q1, Q6DN19, Q6YNR2, Q6YNR3, Q9BYY7, Q9UC24
      UniProtKB/TrEMBL
      A0A0E3SU01, A0A0S2Z3E7
      Related
      ENSP00000349084.4, ENST00000356660.9
      Conserved Domains (1) summary
      smart00140
      Location:133 → 240
      NGF; Nerve growth factor (NGF or beta-NGF)

    13. NM_170731.5 → NP_733927.1  brain-derived neurotrophic factor isoform b precursor

      See identical proteins and their annotated locations for NP_733927.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), also known as I, BDNF1, or 1-5, represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (b) contains a longer N-terminus compared to isoform a. This isoform (b) may undergo proteolytic processing similar to isoform a.
      Source sequence(s)
      AC103796, AC104563, KF459669
      Consensus CDS
      CCDS7865.1
      UniProtKB/TrEMBL
      A0A0S2Z3E7
      Related
      ENSP00000320002.6, ENST00000314915.6
      Conserved Domains (1) summary
      smart00140
      Location:141 → 248
      NGF; Nerve growth factor (NGF or beta-NGF)

    14. NM_170732.4 → NP_733928.1  brain-derived neurotrophic factor isoform a preproprotein

      See identical proteins and their annotated locations for NP_733928.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), also known as IIc, BDNF2C, or 2-5, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
      Source sequence(s)
      EF674519
      Consensus CDS
      CCDS7866.1
      UniProtKB/Swiss-Prot
      A7LA85, A7LA92, D3DQZ2, P23560, Q598Q1, Q6DN19, Q6YNR2, Q6YNR3, Q9BYY7, Q9UC24
      UniProtKB/TrEMBL
      A0A0E3SU01, A0A0S2Z3E7
      Related
      ENSP00000379305.3, ENST00000395981.7
      Conserved Domains (1) summary
      smart00140
      Location:133 → 240
      NGF; Nerve growth factor (NGF or beta-NGF)

    15. NM_170733.4 → NP_733929.1  brain-derived neurotrophic factor isoform a preproprotein

      See identical proteins and their annotated locations for NP_733929.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), also known as IV, BDNF4, or 3-5, differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
      Source sequence(s)
      AC104563, KF459669
      Consensus CDS
      CCDS7866.1
      UniProtKB/Swiss-Prot
      A7LA85, A7LA92, D3DQZ2, P23560, Q598Q1, Q6DN19, Q6YNR2, Q6YNR3, Q9BYY7, Q9UC24
      UniProtKB/TrEMBL
      A0A0E3SU01, A0A0S2Z3E7
      Related
      ENST00000584049.5
      Conserved Domains (1) summary
      smart00140
      Location:133 → 240
      NGF; Nerve growth factor (NGF or beta-NGF)

    16. NM_170734.4 → NP_733930.1  brain-derived neurotrophic factor isoform c precursor

      See identical proteins and their annotated locations for NP_733930.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), also known as VIIb, BDNF6B, or 4I-5, represents use of an alternate promoter and differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (c) contains a longer N-terminus and lacks a predicted signal peptide compared to isoform a.
      Source sequence(s)
      AC104563, KF459669
      Consensus CDS
      CCDS41628.1
      UniProtKB/Swiss-Prot
      P23560
      Related
      ENSP00000379309.2, ENST00000395986.6
      Conserved Domains (1) summary
      smart00140
      Location:148 → 255
      NGF; Nerve growth factor (NGF or beta-NGF)

    17. NM_170735.6 → NP_733931.1  brain-derived neurotrophic factor isoform a preproprotein

      See identical proteins and their annotated locations for NP_733931.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), also known as IX, represents the longest transcript. Variants 1, 2, 4, 5, and 7-16 encode the same isoform (a).
      Source sequence(s)
      AC104563, KF459669
      Consensus CDS
      CCDS7866.1
      UniProtKB/Swiss-Prot
      A7LA85, A7LA92, D3DQZ2, P23560, Q598Q1, Q6DN19, Q6YNR2, Q6YNR3, Q9BYY7, Q9UC24
      UniProtKB/TrEMBL
      A0A0E3SU01, A0A0S2Z3E7
      Related
      ENSP00000437138.1, ENST00000525528.1
      Conserved Domains (1) summary
      smart00140
      Location:133 → 240
      NGF; Nerve growth factor (NGF or beta-NGF)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      27654893..27722030 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      27795301..27862460 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001143815.1: Suppressed sequence

      Description
      NM_001143815.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript, which contains non-consensus splice sites in the 5' UTR.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23560.1 GenPept UniProtKB/Swiss-Prot:P23560

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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