TLR5 toll like receptor 5 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: TLR5provided by VGNC
Official Full Name: toll like receptor 5provided by VGNC
Primary source: VGNC:VGNC:52835
See related: BGD:BT27162; Ensembl:ENSBTAG00000000477
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: TLR-5
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	16	NC_037343.1 (26601164..26603747, complement)

Chromosome 16 - NC_037343.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037343.1 Chromosome 16 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Both HEK293 (human origin) and embryonic bovine lung cells transfected with bTLR5 responded to addition of H7 flagellin. Responses were significantly reduced when mutations were introduced into the TLR5-binding regions of H7 flagellin.
Title: Functional analysis of bovine TLR5 and association with IgA responses of cattle following systemic immunisation with H7 flagella.
Prediction and comparison of TLR protein domain architectures for multiple species revealed seven conserved regions of LRR patterning associated with the three genes investigated.
Title: Sequence variability and protein domain architectures for bovine Toll-like receptors 1, 5, and 10.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in toll-like receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: toll-like receptor 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001040501.1 → NP_001035591.1 toll-like receptor 5 precursor

See identical proteins and their annotated locations for NP_001035591.1

Status: PROVISIONAL

Source sequence(s)

AY634631

UniProtKB/TrEMBL

Q2LDA0, Q6GV18

Related

ENSBTAP00000000604.7, ENSBTAT00000000604.7

Conserved Domains (5) summary

cd00116
Location:89 → 208

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:293 → 313

LRR_RI; leucine-rich repeat [structural motif]

pfam01582
Location:693 → 825

TIR; TIR domain

pfam13855
Location:313 → 372

LRR_8; Leucine rich repeat

cl15307
Location:579 → 618

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain