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    FHL2 four and a half LIM domains 2 [ Homo sapiens (human) ]

    Gene ID: 2274, updated on 2-Nov-2024

    Summary

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    Official Symbol
    FHL2provided by HGNC
    Official Full Name
    four and a half LIM domains 2provided by HGNC
    Primary source
    HGNC:HGNC:3703
    See related
    Ensembl:ENSG00000115641 MIM:602633; AllianceGenome:HGNC:3703
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DRAL; AAG11; FHL-2; SLIM3; SLIM-3
    Summary
    This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2016]
    Expression
    Biased expression in heart (RPKM 149.2), ovary (RPKM 139.8) and 13 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FHL2 in Genome Data Viewer
    Location:
    2q12.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (105357712..105438529, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (105818881..105899699, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (105974169..106054986, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:105866724-105867602 Neighboring gene transforming growth factor beta receptor associated protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16313 Neighboring gene Sharpr-MPRA regulatory region 6730 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11837 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16314 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16315 Neighboring gene C2orf49 divergent transcript Neighboring gene chromosome 2 open reading frame 49 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:105985867-105986368 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:105986369-105986868 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16316 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:106015289-106016111 Neighboring gene NANOG hESC enhancer GRCh37_chr2:106043866-106044367 Neighboring gene uncharacterized LOC105373529 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:106093757-106093969 Neighboring gene VISTA enhancer hs2590 Neighboring gene uncharacterized LOC105375311

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Epithelial expression of FHL2 is negatively associated with metastasis-free and overall survival in colorectal cancer. Verset L, et al. Br J Cancer, 2013 Jul 9. PMID 23756870, Free PMC Article
    2. Expression of the transcriptional coregulator FHL2 in human breast cancer: a clinicopathologic study. Gabriel B, et al. J Soc Gynecol Investig, 2006 Jan. PMID 16378916
    3. Tumoral expression of nuclear cofactor FHL2 is associated with lymphatic metastasis in sporadic but not in HNPCC-associated colorectal cancer. Al-Nomani L, et al. Pathol Res Pract, 2015 Feb. PMID 25554651
    4. How (Epi)Genetic Regulation of the LIM-Domain Protein FHL2 Impacts Multifactorial Disease. Habibe JJ, et al. Cells, 2021 Oct 1. PMID 34685595, Free PMC Article
    5. Suppression of FHL2 expression induces cell differentiation and inhibits gastric and colon carcinogenesis. Wang J, et al. Gastroenterology, 2007 Mar. PMID 17383428

    See all (229) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Four and a half LIM domains 2 (FHL2) attenuates tumorigenesis of gastrointestinal stromal tumors (GISTs) by negatively regulating KIT signaling.
      Title: Four and a half LIM domains 2 (FHL2) attenuates tumorigenesis of gastrointestinal stromal tumors (GISTs) by negatively regulating KIT signaling.
    2. FHL2 promotes the aggressiveness of lung adenocarcinoma by inhibiting autophagy via activation of the PI3K/AKT/mTOR pathway.
      Title: FHL2 promotes the aggressiveness of lung adenocarcinoma by inhibiting autophagy via activation of the PI3K/AKT/mTOR pathway.
    3. Downregulation of FHL2 suppressed trophoblast migration, invasion and epithelial-mesenchymal transition in recurrent miscarriage.
      Title: Downregulation of FHL2 suppressed trophoblast migration, invasion and epithelial-mesenchymal transition in recurrent miscarriage.
    4. FHL2 Inhibits SARS-CoV-2 Replication by Enhancing IFN-beta Expression through Regulating IRF-3.
      Title: FHL2 Inhibits SARS-CoV-2 Replication by Enhancing IFN-β Expression through Regulating IRF-3.
    5. The roles of FHL2 in cancer.
      Title: The roles of FHL2 in cancer.
    6. FHL2 Genetic Polymorphisms and Pro-Diabetogenic Lipid Profile in the Multiethnic HELIUS Cohort.
      Title: FHL2 Genetic Polymorphisms and Pro-Diabetogenic Lipid Profile in the Multiethnic HELIUS Cohort.
    7. High FHL2 mRNA expression and its prognostic value in lung cancer.
      Title: High FHL2 mRNA expression and its prognostic value in lung cancer.
    8. High level of FHL2 exacerbates the outcome of non-small cell lung cancer (NSCLC) patients and the malignant phenotype in NSCLC cells.
      Title: High level of FHL2 exacerbates the outcome of non-small cell lung cancer (NSCLC) patients and the malignant phenotype in NSCLC cells.
    9. c-Abl kinase regulates cell proliferation and ionizing radiation-induced G2/M arrest via phosphorylation of FHL2.
      Title: c-Abl kinase regulates cell proliferation and ionizing radiation-induced G2/M arrest via phosphorylation of FHL2.
    10. How (Epi)Genetic Regulation of the LIM-Domain Protein FHL2 Impacts Multifactorial Disease.
      Title: How (Epi)Genetic Regulation of the LIM-Domain Protein FHL2 Impacts Multifactorial Disease.
    Submit: New GeneRIF Correction See all GeneRIFs (100)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables bHLH transcription factor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in atrial cardiac muscle cell development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in heart trabecula formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of calcineurin-NFAT signaling cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of calcineurin-NFAT signaling cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in osteoblast differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to hormone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ventricular cardiac muscle cell development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Z disc IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion HDA PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    four and a half LIM domains protein 2
    Names
    LIM domain protein DRAL
    aging-associated gene 11
    down-regulated in rhabdomyosarcoma LIM protein
    skeletal muscle LIM-protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008844.2 RefSeqGene

      Range
      5261..82948
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_740

    mRNA and Protein(s)

    1. NM_001039492.3 → NP_001034581.1  four and a half LIM domains protein 2 isoform a

      See identical proteins and their annotated locations for NP_001034581.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 2. Variants 1, 2, 4, 5, 6, 7, 8 and 12 all encode the same isoform (a).
      Source sequence(s)
      AC012360, AC108058, DQ266432, L42176
      Consensus CDS
      CCDS2070.1
      UniProtKB/Swiss-Prot
      Q13229, Q13644, Q14192, Q2I5I4, Q5TM15, Q9P294
      UniProtKB/TrEMBL
      D3DVK0, Q2TSB7, Q561W1, Q6I9R8
      Related
      ENSP00000322909.8, ENST00000322142.13
      Conserved Domains (5) summary
      cd09422
      Location:36 → 97
      LIM1_FHL2; The first LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cd09426
      Location:101 → 157
      LIM2_FHL2; The second LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cd09431
      Location:162 → 218
      LIM3_Fhl2; The third LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cd09433
      Location:221 → 278
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:5 → 33
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    2. NM_001318894.1 → NP_001305823.1  four and a half LIM domains protein 2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 2. Variants 1, 2, 4, 5, 6, 7, 8 and 12 all encode the same isoform (a).
      Source sequence(s)
      AC108058, CR936682, DQ266432
      Consensus CDS
      CCDS2070.1
      UniProtKB/Swiss-Prot
      Q13229, Q13644, Q14192, Q2I5I4, Q5TM15, Q9P294
      UniProtKB/TrEMBL
      D3DVK0, Q2TSB7, Q561W1, Q6I9R8
      Related
      ENSP00000386892.3, ENST00000409177.6
      Conserved Domains (5) summary
      cd09422
      Location:36 → 97
      LIM1_FHL2; The first LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cd09426
      Location:101 → 157
      LIM2_FHL2; The second LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cd09431
      Location:162 → 218
      LIM3_Fhl2; The third LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cd09433
      Location:221 → 278
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:5 → 33
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    3. NM_001318895.3 → NP_001305824.1  four and a half LIM domains protein 2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 2. Variants 1, 2, 4, 5, 6, 7, 8 and 12 all encode the same isoform (a).
      Source sequence(s)
      AC108058, DQ266432
      Consensus CDS
      CCDS2070.1
      UniProtKB/Swiss-Prot
      Q13229, Q13644, Q14192, Q2I5I4, Q5TM15, Q9P294
      UniProtKB/TrEMBL
      D3DVK0, Q2TSB7, Q561W1, Q6I9R8
      Related
      ENSP00000433567.2, ENST00000530340.6
      Conserved Domains (5) summary
      cd09422
      Location:36 → 97
      LIM1_FHL2; The first LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cd09426
      Location:101 → 157
      LIM2_FHL2; The second LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cd09431
      Location:162 → 218
      LIM3_Fhl2; The third LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cd09433
      Location:221 → 278
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:5 → 33
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    4. NM_001318896.2 → NP_001305825.1  four and a half LIM domains protein 2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 2. Variants 1, 2, 4, 5, 6, 7, 8 and 12 all encode the same isoform (a).
      Source sequence(s)
      AC012360, AL521653, DA682076, DQ266432
      Consensus CDS
      CCDS2070.1
      UniProtKB/Swiss-Prot
      Q13229, Q13644, Q14192, Q2I5I4, Q5TM15, Q9P294
      UniProtKB/TrEMBL
      D3DVK0, Q2TSB7, Q561W1, Q6I9R8
      Related
      ENSP00000386633.1, ENST00000408995.5
      Conserved Domains (5) summary
      cd09422
      Location:36 → 97
      LIM1_FHL2; The first LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cd09426
      Location:101 → 157
      LIM2_FHL2; The second LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cd09431
      Location:162 → 218
      LIM3_Fhl2; The third LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cd09433
      Location:221 → 278
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:5 → 33
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    5. NM_001318897.2 → NP_001305826.1  four and a half LIM domains protein 2 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR and lacks an alternate exon compared to variant 2. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 9 and 10 both encode the same isoform (b).
      Source sequence(s)
      AB158503, AC012360, BP257466, DQ266432
      UniProtKB/TrEMBL
      Q53T40
      Conserved Domains (3) summary
      cd09431
      Location:48 → 104
      LIM3_Fhl2; The third LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cd09433
      Location:107 → 164
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:1 → 43
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    6. NM_001318898.2 → NP_001305827.1  four and a half LIM domains protein 2 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) lacks two alternate exons compared to variant 2. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 9 and 10 both encode the same isoform (b).
      Source sequence(s)
      AC012360, BI562043, DQ266432
      UniProtKB/TrEMBL
      Q53T40
      Conserved Domains (3) summary
      cd09431
      Location:48 → 104
      LIM3_Fhl2; The third LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cd09433
      Location:107 → 164
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:1 → 43
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    7. NM_001318899.2 → NP_001305828.1  four and a half LIM domains protein 2 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR and contains an alternate internal exon compared to variant 2. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AC012360, AC108058, BM559077, DA682076, DQ266432
      UniProtKB/TrEMBL
      Q53T40
      Conserved Domains (3) summary
      cd09431
      Location:54 → 110
      LIM3_Fhl2; The third LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cd09433
      Location:113 → 170
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:1 → 49
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    8. NM_001374399.1 → NP_001361328.1  four and a half LIM domains protein 2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) differs in the 5' UTR compared to variant 2. Variants 1, 2, 4, 5, 6, 7, 8 and 12 all encode the same isoform (a).
      Source sequence(s)
      AC012360, AC068273, AC108058
      Consensus CDS
      CCDS2070.1
      UniProtKB/Swiss-Prot
      Q13229, Q13644, Q14192, Q2I5I4, Q5TM15, Q9P294
      UniProtKB/TrEMBL
      D3DVK0, Q2TSB7, Q561W1, Q6I9R8
      Related
      ENSP00000386665.1, ENST00000409807.5
      Conserved Domains (5) summary
      cd09422
      Location:36 → 97
      LIM1_FHL2; The first LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cd09426
      Location:101 → 157
      LIM2_FHL2; The second LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cd09431
      Location:162 → 218
      LIM3_Fhl2; The third LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cd09433
      Location:221 → 278
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:5 → 33
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    9. NM_001450.4 → NP_001441.4  four and a half LIM domains protein 2 isoform a

      See identical proteins and their annotated locations for NP_001441.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 2. Variants 1, 2, 4, 5, 6, 7, 8 and 12 all encode the same isoform (a).
      Source sequence(s)
      AA758053, AC012360, BC014397, L42176
      Consensus CDS
      CCDS2070.1
      UniProtKB/Swiss-Prot
      Q13229, Q13644, Q14192, Q2I5I4, Q5TM15, Q9P294
      UniProtKB/TrEMBL
      D3DVK0, Q2TSB7, Q561W1, Q6I9R8
      Related
      ENSP00000377021.3, ENST00000393353.7
      Conserved Domains (5) summary
      cd09422
      Location:36 → 97
      LIM1_FHL2; The first LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cd09426
      Location:101 → 157
      LIM2_FHL2; The second LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cd09431
      Location:162 → 218
      LIM3_Fhl2; The third LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cd09433
      Location:221 → 278
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:5 → 33
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    10. NM_201555.3 → NP_963849.1  four and a half LIM domains protein 2 isoform a

      See identical proteins and their annotated locations for NP_963849.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes isoform a. Variants 1, 2, 4, 5, 6, 7, 8 and 12 all encode the same isoform.
      Source sequence(s)
      BC014397, L42176
      Consensus CDS
      CCDS2070.1
      UniProtKB/Swiss-Prot
      Q13229, Q13644, Q14192, Q2I5I4, Q5TM15, Q9P294
      UniProtKB/TrEMBL
      D3DVK0, Q2TSB7, Q561W1, Q6I9R8
      Related
      ENSP00000344266.5, ENST00000344213.9
      Conserved Domains (5) summary
      cd09422
      Location:36 → 97
      LIM1_FHL2; The first LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cd09426
      Location:101 → 157
      LIM2_FHL2; The second LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cd09431
      Location:162 → 218
      LIM3_Fhl2; The third LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cd09433
      Location:221 → 278
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:5 → 33
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    11. NM_201557.5 → NP_963851.2  four and a half LIM domains protein 2 isoform a

      See identical proteins and their annotated locations for NP_963851.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 2. Variants 1, 2, 4, 5, 6, 7, 8 and 12 all encode the same isoform (a).
      Source sequence(s)
      BP257466, DQ266432, U29332
      Consensus CDS
      CCDS2070.1
      UniProtKB/Swiss-Prot
      Q13229, Q13644, Q14192, Q2I5I4, Q5TM15, Q9P294
      UniProtKB/TrEMBL
      D3DVK0, Q2TSB7, Q561W1, Q6I9R8
      Related
      ENSP00000377020.3, ENST00000393352.7
      Conserved Domains (5) summary
      cd09422
      Location:36 → 97
      LIM1_FHL2; The first LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cd09426
      Location:101 → 157
      LIM2_FHL2; The second LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cd09431
      Location:162 → 218
      LIM3_Fhl2; The third LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cd09433
      Location:221 → 278
      LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
      cl02475
      Location:5 → 33
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      105357712..105438529 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      105818881..105899699 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_201556.1: Suppressed sequence

      Description
      NM_201556.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14192.3 GenPept UniProtKB/Swiss-Prot:Q14192

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