Tff3 trefoil factor 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tff3provided by RGD
Official Full Name: trefoil factor 3provided by RGD
Primary source: RGD:3847
See related: EnsemblRapid:ENSRNOG00000001159 AllianceGenome:RGD:3847
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ITF
Summary: Predicted to enable identical protein binding activity. Involved in response to peptide hormone. Predicted to be located in extracellular region and secretory granule. Predicted to be active in extracellular space. Biomarker of colon cancer and pre-malignant neoplasm. Orthologous to human TFF3 (trefoil factor 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 1148.2) See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (9194623..9199333, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (9193259..9197969, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (9850800..9855481, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ITF can improve cytomorphosis ability for promoting cell migration with limited effect on cell proliferation, which can be enhanced with addition of mucin. The main mechanism of ITF in maintaining intestinal mucosal barrier may be attributed to acceleration of cell migration.
Title: Role of intestinal trefoil factor in protecting intestinal epithelial cells from burn-induced injury.
These results suggest that TFF3 may promote adhesion and spreading of cells to accelerate beta-cell maturation. This study indicates a functional role for TFF3 in pancreatic beta-cell maturation in the perinatal period, which is altered by low protein diet during gestation.
Title: Trefoil factor 3 in perinatal pancreas is increased by gestational low protein diet and associated with accelerated β-cell maturation.
The expression in activated microglial cells, which is demonstrated here for the first time, points towards a possible function for Tff3 in immune reactions in the CNS
Title: Tff3 is expressed in neurons and microglial cells.
Substantial amounts of TFF1 were detected only in the cytoplasm of epithelial cells in the submandibular glands granular convoluted tubules (GCT), while TFF2 and TFF3 were widely distributed in the cytoplasm of epithelial cells of intercalated ducts
Title: Expression and localization of trefoil factor family genes in rat submandibular glands.
Goblet cell-secreted TFF3, IgGFcgammaBP and Muc2, existing in the two intestinal mucus layers, are bound together by covalent interactions in the soluble fraction of intestinal mucus and form heteropolymers.
Title: The rat IgGFcγBP and Muc2 C-terminal domains and TFF3 in two intestinal mucus layers bind together by covalent interaction.
Expression of TFF-3 was increased in esophageal intestinal mucosa compared with jejunum (p = 0.0002), but there was significant overlap in expression between these tissues for this gene.
Title: Validation of a rodent model of Barrett's esophagus using quantitative gene expression profiling.
TFF3 contributes to the malignant behavior of colon cancer cells.
Title: Trefoil factor-3 expression in human colon cancer liver metastasis.
Findings reveal a novel TFF3-mediated pathway for stimulation of beta-cell replication that could ultimately be exploited for expansion or preservation of islet beta-cell mass.
Title: Trefoil factor 3 stimulates human and rodent pancreatic islet beta-cell replication with retention of function.
reduced submucosal and lamina propria separation in neonatal necrotizing enterocolitis model
Title: Intestinal trefoil factor in treatment of neonatal necrotizing enterocolitis in the rat model.
Down regulation of trefoil factor 3 and up regulation of cathepsin L may contribute to lack of protection and increased age related tissue damage to kidney in aging.
Title: Altered expression of trefoil factor 3 and cathepsin L gene in rat kidney during aging.

Submit: New GeneRIF Correction See all GeneRIFs (15)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in maintenance of gastrointestinal epithelium	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of glucose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: trefoil factor 3

Names: intestinal trefoil factor; polypeptide P1.B; trefoil factor 3, intestinal

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.