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    Stx8 syntaxin 8 [ Mus musculus (house mouse) ]

    Gene ID: 55943, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Stx8provided by MGI
    Official Full Name
    syntaxin 8provided by MGI
    Primary source
    MGI:MGI:1890156
    See related
    Ensembl:ENSMUSG00000020903 AllianceGenome:MGI:1890156
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CARB; 0610007H08Rik; 1110002H11Rik; 4930571E13Rik
    Summary
    Enables ubiquitin protein ligase binding activity. Acts upstream of or within cellular response to type II interferon. Located in phagocytic vesicle. Is active in late endosome. Orthologous to human STX8 (syntaxin 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 3.4), testis adult (RPKM 2.7) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Stx8 in Genome Data Viewer
    Location:
    11 B3; 11 41.2 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (67857237..68097974)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (67966411..68207148)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 43 Neighboring gene cilia and flagella associated protein 52 Neighboring gene STARR-seq mESC enhancer starr_29808 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:67939507-67939823 Neighboring gene ribosomal protein L31 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:68012718-68012928 Neighboring gene expressed sequence C78197 Neighboring gene microRNA 6406 Neighboring gene netrin 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:68084195-68084304 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:68084370-68084566 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:68084658-68084931 Neighboring gene STARR-seq mESC enhancer starr_29815 Neighboring gene STARR-seq mESC enhancer starr_29816 Neighboring gene predicted gene, 31954

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Syntaxin 8 regulates platelet dense granule secretion, aggregation, and thrombus stability. Golebiewska EM, et al. J Biol Chem, 2015 Jan 16. PMID 25404741, Free PMC Article
    2. The two-pore channel TPC1 is required for efficient protein processing through early and recycling endosomes. Castonguay J, et al. Sci Rep, 2017 Aug 30. PMID 28855648, Free PMC Article
    3. Interaction between syntaxin 8 and HECTd3, a HECT domain ligase. Zhang L, et al. Cell Mol Neurobiol, 2009 Feb. PMID 18821010
    4. BLOC-1 complex deficiency alters the targeting of adaptor protein complex-3 cargoes. Salazar G, et al. Mol Biol Cell, 2006 Sep. PMID 16760431, Free PMC Article
    5. Dry ice is a reliable substrate for the distribution of frozen mouse spermatozoa: A multi-centric study. Raspa M, et al. Theriogenology, 2017 Jul 1. PMID 28532839

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Syntaxin 8 has a role in regulating platelet dense granule secretion, aggregation, and thrombus stability
      Title: Syntaxin 8 regulates platelet dense granule secretion, aggregation, and thrombus stability.
    2. Syntaxin 8 and HECTd3 have similar subcellular localization.
      Title: Interaction between syntaxin 8 and HECTd3, a HECT domain ligase.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SNAP receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SNARE binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables chloride channel inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chloride channel inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables syntaxin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables syntaxin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to type II interferon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in early endosome to late endosome transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in early endosome to late endosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endosome to lysosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein localization to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SNARE complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in late endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in late endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in phagocytic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in recycling endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in recycling endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    syntaxin-8
    Names
    syntaxin-like protein 3I35

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356314.1 → NP_001343243.1  syntaxin-8 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 2, which is shorter and has a novel C-terminus, compared to isoform 1.
      Source sequence(s)
      AK003297, AK011376, AL663076
      Consensus CDS
      CCDS88173.1
      UniProtKB/TrEMBL
      Q9D0J1
      Related
      ENSMUSP00000021286.5, ENSMUST00000021286.11

    2. NM_001361350.1 → NP_001348279.1  syntaxin-8 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL663076, AL669842
      Conserved Domains (1) summary
      cd15852
      Location:41 → 95
      SNARE_Syntaxin8; SNARE motif of syntaxin 8

    3. NM_001361351.1 → NP_001348280.1  syntaxin-8 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK003297, AK018716, BC048167
      Conserved Domains (1) summary
      cd15852
      Location:41 → 95
      SNARE_Syntaxin8; SNARE motif of syntaxin 8

    4. NM_001361352.1 → NP_001348281.1  syntaxin-8 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AK003297, AK035105, AL663076, BE984450
      Consensus CDS
      CCDS88174.1
      UniProtKB/TrEMBL
      Q8BS59
      Related
      ENSMUSP00000104315.2, ENSMUST00000108675.2

    5. NM_018768.3 → NP_061238.1  syntaxin-8 isoform 1

      See identical proteins and their annotated locations for NP_061238.1

      Status: VALIDATED

      Source sequence(s)
      AK003297, BC048167
      Consensus CDS
      CCDS24863.1
      UniProtKB/Swiss-Prot
      O88983
      Related
      ENSMUSP00000021285.8, ENSMUST00000021285.14
      Conserved Domains (1) summary
      cd15852
      Location:152 → 206
      SNARE_Syntaxin8; SNARE motif of syntaxin 8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      67857237..68097974
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246161.1 → XP_030102021.1  syntaxin-8 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88983.1 GenPept UniProtKB/Swiss-Prot:O88983

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