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    Tmprss2 transmembrane serine protease 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 156435, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tmprss2provided by RGD
    Official Full Name
    transmembrane serine protease 2provided by RGD
    Primary source
    RGD:620766
    See related
    EnsemblRapid:ENSRNOG00000001976 AllianceGenome:RGD:620766
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein autoprocessing. Predicted to be located in nucleoplasm and plasma membrane. Orthologous to human TMPRSS2 (transmembrane serine protease 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 244.3), Lung (RPKM 71.7) and 4 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmprss2 in Genome Data Viewer
    Location:
    11q12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (50403707..50443224, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (36934306..36973779, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (38063914..38103406, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene FAM3 metabolism regulating signaling molecule B Neighboring gene uncharacterized LOC134480979 Neighboring gene MX dynamin like GTPase 2 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene ornithine decarboxylase antizyme 1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Obesogenic and Ketogenic Diets Distinctly Regulate the SARS-CoV-2 Entry Proteins ACE2 and TMPRSS2 and the Renin-Angiotensin System in Rat Lung and Heart Tissues. Da Eira D, et al. Nutrients, 2021 Sep 25. PMID 34684358, Free PMC Article
    2. ACE2 and TMPRSS2 immunolocalization and oral manifestations of COVID-19. Park GC, et al. Oral Dis, 2022 Nov. PMID 35000261
    3. Expression of ACE2 and TMPRSS2 Proteins in the Upper and Lower Aerodigestive Tracts of Rats: Implications on COVID 19 Infections. Sato T, et al. Laryngoscope, 2021 Mar. PMID 32940922
    4. The androgen-regulated type II serine protease TMPRSS2 is differentially expressed and mislocalized in prostate adenocarcinoma. Lucas JM, et al. J Pathol, 2008 Jun. PMID 18338334
    5. TMPRSS2 Contributes to Virus Spread and Immunopathology in the Airways of Murine Models after Coronavirus Infection. Iwata-Yoshikawa N, et al. J Virol, 2019 Mar 15. PMID 30626688, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ACE2 and TMPRSS2 immunolocalization and oral manifestations of COVID-19.
      Title: ACE2 and TMPRSS2 immunolocalization and oral manifestations of COVID-19.
    2. Obesogenic and Ketogenic Diets Distinctly Regulate the SARS-CoV-2 Entry Proteins ACE2 and TMPRSS2 and the Renin-Angiotensin System in Rat Lung and Heart Tissues.
      Title: Obesogenic and Ketogenic Diets Distinctly Regulate the SARS-CoV-2 Entry Proteins ACE2 and TMPRSS2 and the Renin-Angiotensin System in Rat Lung and Heart Tissues.
    3. Pulmonary, cardiac and renal distribution of ACE2, furin, TMPRSS2 and ADAM17 in rats with heart failure: Potential implication for COVID-19 disease.
      Title: Pulmonary, cardiac and renal distribution of ACE2, furin, TMPRSS2 and ADAM17 in rats with heart failure: Potential implication for COVID-19 disease.
    4. Expression of ACE2 and TMPRSS2 Proteins in the Upper and Lower Aerodigestive Tracts of Rats: Implications on COVID 19 Infections.
      Title: Expression of ACE2 and TMPRSS2 Proteins in the Upper and Lower Aerodigestive Tracts of Rats: Implications on COVID 19 Infections.
    5. Six differentially expressed genes (Kcne1, Rcan1, Mx1, Mx2, Tmprss2, and RGD1559516) were identified in the renal cortex, and three genes (Rcan1, Mx2, and Tmprss2) were identified in the renal medulla.
      Title: [Differentially expressed genes in the locus associated with relative kidney weight and resting blood pressure in hypertensive rats of the ISIAH strain].
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of viral entry into host cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein autoprocessing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protease serine 2
    Names
    transmembrane protease, serine 2
    NP_569108.2
    XP_008766769.1
    XP_008766770.1
    XP_063126320.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_130424.3 → NP_569108.2  transmembrane protease serine 2

      See identical proteins and their annotated locations for NP_569108.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000011
      UniProtKB/TrEMBL
      F7EQ71, Q6P7D7, Q920K3
      Related
      ENSRNOP00000062828.1, ENSRNOT00000066413.5
      Conserved Domains (4) summary
      smart00020
      Location:253 → 482
      Tryp_SPc; Trypsin-like serine protease
      cd00112
      Location:112 → 147
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:254 → 485
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam15494
      Location:152 → 247
      SRCR_2; Scavenger receptor cysteine-rich domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      50403707..50443224 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008768547.4 → XP_008766769.1  transmembrane protease serine 2 isoform X1

      See identical proteins and their annotated locations for XP_008766769.1

      UniProtKB/TrEMBL
      Q920K3
      Conserved Domains (4) summary
      smart00020
      Location:253 → 482
      Tryp_SPc; Trypsin-like serine protease
      cd00112
      Location:112 → 147
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:254 → 485
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam15494
      Location:152 → 247
      SRCR_2; Scavenger receptor cysteine-rich domain

    2. XM_008768548.4 → XP_008766770.1  transmembrane protease serine 2 isoform X1

      See identical proteins and their annotated locations for XP_008766770.1

      UniProtKB/TrEMBL
      Q920K3
      Conserved Domains (4) summary
      smart00020
      Location:253 → 482
      Tryp_SPc; Trypsin-like serine protease
      cd00112
      Location:112 → 147
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd00190
      Location:254 → 485
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam15494
      Location:152 → 247
      SRCR_2; Scavenger receptor cysteine-rich domain

    3. XM_063270250.1 → XP_063126320.1  transmembrane protease serine 2 isoform X2

      UniProtKB/TrEMBL
      F7EQ71, Q6P7D7
    Nucleotide Protein Strain
    Heading Accession and Version

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