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    Pi4kb phosphatidylinositol 4-kinase beta [ Mus musculus (house mouse) ]

    Gene ID: 107650, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Pi4kbprovided by MGI
    Official Full Name
    phosphatidylinositol 4-kinase betaprovided by MGI
    Primary source
    MGI:MGI:1334433
    See related
    Ensembl:ENSMUSG00000038861 AllianceGenome:MGI:1334433
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ESTM41; Pik4cb; PI4Kbeta; PI4K-beta
    Summary
    Predicted to enable 1-phosphatidylinositol 4-kinase activity and 14-3-3 protein binding activity. Predicted to be involved in inner ear development; phosphatidylinositol phosphate biosynthetic process; and phosphatidylinositol-mediated signaling. Predicted to act upstream of or within lysosome organization. Predicted to be located in Golgi membrane. Predicted to be active in cytoplasm and membrane. Is expressed in several structures, including extraembryonic component; neural ectoderm; and vertebral axis musculature. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness. Orthologous to human PI4KB (phosphatidylinositol 4-kinase beta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 17.1), bladder adult (RPKM 16.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pi4kb in Genome Data Viewer
    Location:
    3 F2.1; 3 40.74 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (94882042..94914248)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (94974731..95006937)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene selenium binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E231 Neighboring gene RIKEN cDNA B230398E01 gene Neighboring gene regulatory factor X, 5 (influences HLA class II expression) Neighboring gene STARR-seq mESC enhancer starr_08361 Neighboring gene STARR-positive B cell enhancer ABC_E652 Neighboring gene STARR-positive B cell enhancer ABC_E3449 Neighboring gene zinc finger protein 687 Neighboring gene microRNA 7013 Neighboring gene RIKEN cDNA 4930481B07 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:94820548-94820749 Neighboring gene STARR-positive B cell enhancer ABC_E4560 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Locational and functional characterization of PI4KB in the mouse embryo. Zhao H, et al. J Cell Physiol, 2024 Apr. PMID 38230579
    2. Myelination of peripheral nerves is controlled by PI4KB through regulation of Schwann cell Golgi function. Baba T, et al. Proc Natl Acad Sci U S A, 2020 Nov 10. PMID 33106410, Free PMC Article
    3. Aldosterone-induced ENaC and basal Na+/K+-ATPase trafficking via protein kinase D1-phosphatidylinositol 4-kinaseIIIβ trans Golgi signalling in M1 cortical collecting duct cells. Dooley R, et al. Mol Cell Endocrinol, 2013 Jun 15. PMID 23541637
    4. PI4KIIIβ-Mediated Phosphoinositides Metabolism Regulates Function of the VTA Dopaminergic Neurons and Depression-Like Behavior. Sang Y, et al. J Neurosci, 2024 Mar 13. PMID 38267258, Free PMC Article
    5. Distinct plasma-membrane PtdIns(4)P and PtdIns(4,5)P2 dynamics in secretagogue-stimulated beta-cells. Wuttke A, et al. J Cell Sci, 2010 May 1. PMID 20375060

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Locational and functional characterization of PI4KB in the mouse embryo.
      Title: Locational and functional characterization of PI4KB in the mouse embryo.
    2. Myelination of peripheral nerves is controlled by PI4KB through regulation of Schwann cell Golgi function.
      Title: Myelination of peripheral nerves is controlled by PI4KB through regulation of Schwann cell Golgi function.
    3. oijbih iuhg iugh uh jkgh uib
      Title: Aldosterone-induced ENaC and basal Na+/K+-ATPase trafficking via protein kinase D1-phosphatidylinositol 4-kinaseIIIβ trans Golgi signalling in M1 cortical collecting duct cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol 4-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-phosphatidylinositol 4-kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 1-phosphatidylinositol 4-kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 14-3-3 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 14-3-3 protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in inner ear development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inner ear development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inner ear development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within lysosome organization ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in rough endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol 4-kinase beta
    Names
    phosphatidylinositol 4-kinase, catalytic, beta polypeptide
    ptdIns 4-kinase beta
    NP_001280644.1
    NP_001280645.1
    NP_780565.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001293715.1 → NP_001280644.1  phosphatidylinositol 4-kinase beta isoform 1

      See identical proteins and their annotated locations for NP_001280644.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript (1) and encodes the longest isoform (1).
      Source sequence(s)
      AC087062
      Consensus CDS
      CCDS79978.1
      UniProtKB/Swiss-Prot
      Q14CH6, Q14DJ4, Q3TA58, Q68FH2, Q8BKC8, Q8C146
      UniProtKB/TrEMBL
      E9Q8A3
      Related
      ENSMUSP00000102872.3, ENSMUST00000107251.9
      Conserved Domains (1) summary
      cd05168
      Location:529 → 816
      PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta

    2. NM_001293716.1 → NP_001280645.1  phosphatidylinositol 4-kinase beta isoform 3

      See identical proteins and their annotated locations for NP_001280645.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation from a downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC087062, AK157918, BC113781, BQ443265
      Consensus CDS
      CCDS79979.1
      UniProtKB/Swiss-Prot
      Q8BKC8
      Related
      ENSMUSP00000132150.2, ENSMUST00000167008.8
      Conserved Domains (1) summary
      cd05168
      Location:197 → 484
      PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta

    3. NM_175356.3 → NP_780565.2  phosphatidylinositol 4-kinase beta isoform 2

      See identical proteins and their annotated locations for NP_780565.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC087062, AK157918, BQ443265
      Consensus CDS
      CCDS17599.1
      UniProtKB/TrEMBL
      E9Q8A3
      Related
      ENSMUSP00000072134.6, ENSMUST00000072287.12
      Conserved Domains (1) summary
      cd05168
      Location:514 → 801
      PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      94882042..94914248
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BKC8.2 GenPept UniProtKB/Swiss-Prot:Q8BKC8

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