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    mgmt O-6-methylguanine-DNA methyltransferase [ Danio rerio (zebrafish) ]

    Gene ID: 553368, updated on 2-Nov-2024

    Summary

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    Official Symbol
    mgmtprovided by ZNC
    Official Full Name
    O-6-methylguanine-DNA methyltransferaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-120614-1
    See related
    Ensembl:ENSDARG00000043275 AllianceGenome:ZFIN:ZDB-GENE-120614-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable methylated-DNA-[protein]-cysteine S-methyltransferase activity. Predicted to be involved in DNA repair. Predicted to act upstream of or within DNA damage response and methylation. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); endocrine gland cancer (multiple); granulosa cell tumor; high grade glioma (multiple); and retinoblastoma. Orthologous to human MGMT (O-6-methylguanine-DNA methyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See mgmt in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (20214215..20218391, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (20194379..20198555, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene si:ch211-248a14.8 Neighboring gene ecdysoneless homolog (Drosophila) Neighboring gene gonadotropin-releasing hormone 3 Neighboring gene EBF transcription factor 3b Neighboring gene BCL2 interacting protein 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Associations Between Behavioral Effects of Bisphenol A and DNA Methylation in Zebrafish Embryos. Olsvik PA, et al. Front Genet, 2019. PMID 30906313, Free PMC Article
    2. A Germline-Specific Regulator of Mitochondrial Fusion is Required for Maintenance and Differentiation of Germline Stem and Progenitor Cells. Zhang R, et al. Adv Sci (Weinh), 2022 Dec. PMID 36257818, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated-DNA-[protein]-cysteine S-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylated-DNA-[protein]-cysteine S-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    methylated-DNA--protein-cysteine methyltransferase
    NP_001243172.1
    NP_001243173.1
    NP_001243174.1
    NP_001243175.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256243.1 → NP_001243172.1  methylated-DNA--protein-cysteine methyltransferase isoform 1

      See identical proteins and their annotated locations for NP_001243172.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein (isoform 1). Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BX005375
      UniProtKB/TrEMBL
      A0A8M1NYZ8, F1R3V2
      Related
      ENSDARP00000129345.1, ENSDART00000156540.3
      Conserved Domains (3) summary
      cd06445
      Location:97 → 178
      ATase; The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases ...
      PRK00901
      Location:16 → 178
      PRK00901; methylated-DNA--protein-cysteine methyltransferase; Provisional
      pfam02870
      Location:13 → 93
      Methyltransf_1N; 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain

    2. NM_001256244.1 → NP_001243173.1  methylated-DNA--protein-cysteine methyltransferase isoform 1

      See identical proteins and their annotated locations for NP_001243173.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
      Source sequence(s)
      BX005375
      UniProtKB/TrEMBL
      A0A8M1NYZ8, F1R3V2
      Related
      ENSDARP00000063522.4, ENSDART00000063523.6
      Conserved Domains (3) summary
      cd06445
      Location:97 → 178
      ATase; The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases ...
      PRK00901
      Location:16 → 178
      PRK00901; methylated-DNA--protein-cysteine methyltransferase; Provisional
      pfam02870
      Location:13 → 93
      Methyltransf_1N; 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain

    3. NM_001256245.1 → NP_001243174.1  methylated-DNA--protein-cysteine methyltransferase isoform 2

      See identical proteins and their annotated locations for NP_001243174.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1. Variants 3 and 4 encode the same protein (isoform 2).
      Source sequence(s)
      BX005375
      UniProtKB/TrEMBL
      A0A8M1P3G0, X1WB89
      Related
      ENSDARP00000129855.1, ENSDART00000155990.3
      Conserved Domains (3) summary
      cd06445
      Location:92 → 173
      ATase; The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases ...
      COG0350
      Location:16 → 174
      AdaB; O6-methylguanine-DNA--protein-cysteine methyltransferase [Replication, recombination and repair]
      pfam02870
      Location:13 → 88
      Methyltransf_1N; 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain

    4. NM_001256246.1 → NP_001243175.1  methylated-DNA--protein-cysteine methyltransferase isoform 2

      See identical proteins and their annotated locations for NP_001243175.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate splice site in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1. Variants 3 and 4 encode the same protein (isoform 2).
      Source sequence(s)
      BX005375
      UniProtKB/TrEMBL
      A0A8M1P3G0, X1WB89
      Related
      ENSDARP00000127480.1, ENSDART00000155632.3
      Conserved Domains (3) summary
      cd06445
      Location:92 → 173
      ATase; The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases ...
      COG0350
      Location:16 → 174
      AdaB; O6-methylguanine-DNA--protein-cysteine methyltransferase [Replication, recombination and repair]
      pfam02870
      Location:13 → 88
      Methyltransf_1N; 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      20214215..20218391 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394981.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      196662..200892 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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