IGF1R insulin like growth factor 1 receptor [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: IGF1Rprovided by VGNC
Official Full Name: insulin like growth factor 1 receptorprovided by VGNC
Primary source: VGNC:VGNC:30077
See related: BGD:BT29334; Ensembl:ENSBTAG00000021527
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: IGFR1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	21	NC_037348.1 (7780293..8087168)

Chromosome 21 - NC_037348.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037348.1 Chromosome 21 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

rs110343126 associated with fertility in hot-humid climate
Title: Polymorphisms within the prolactin and growth hormone/insulin-like growth factor-1 functional pathways associated with fertility traits in Holstein cows raised in a hot-humid climate.
A total of 1169 cows of 4 pure breeds (Polish Holstein Friesian, Montbeliarde, Jersey and Holstein Friesian) were genotyped. The T (IGF1R/e2/MspI) and G (IGF1R/e2/TaqI) alleles were found to be prevalent. 3 combinations of genotypes (TT/GG, TT/AG and CT/GG) were associated with the highest productivity (milk, protein and fat yields) among the breeds studied, as opposed to individuals carrying the worst CC/AA combination.
Title: Polymorphism in exon 2 encoding the putative ligand binding pocket of the bovine insulin-like growth factor 1 receptor affects milk traits in four different cattle breeds.
study determined IGFR1 and PAPP-A expression both in follicles at different stages of development and in ovarian cysts; data indicate that animals with cystic ovarian disease (COD) have an altered regulation of the IGF system in the ovary and thus allow postulating IGFR1 expression and PAPP-A secretion as a modulator of IGF1 in cattle with COD
Title: Involvement of PAPP-A and IGFR1 in Cystic Ovarian Disease in Cattle.
Results of the present study showed, for the first time, that the polymorphism in IGF1R is associated with superovulation traits, and indicated that the IGFIR gene can be used as a potential marker for donor selection.
Title: Effects in cattle of genetic variation within the IGF1R gene on the superovulation performance and pregnancy rates after embryo transfer.
two SNPs in the coding region of the insulin-like growth factor 1 receptor gene may have a role in growth of Angus cattle
Title: Association of two SNPs in the coding region of the insulin-like growth factor 1 receptor (IGF1R) gene with growth-related traits in Angus cattle.
insulin-like growth factor (IGF) receptor glycosylation is critical to the maintenance of vascular smooth muscle phenotype in the presence of factors promoting osteogenic differentiation and mineralization
Title: Apposite insulin-like growth factor (IGF) receptor glycosylation is critical to the maintenance of vascular smooth muscle phenotype in the presence of factors promoting osteogenic differentiation and mineralization.
The objective of this study was to estimate the allele and genotype frequencies of the IGF-IR/TaqI, m-calpain/HhaI, and UCP-3/BglI polymorphisms and to determine association between these polymorphisms and growth traits in Chinese indigenous cattle breed.
Title: Association between IGF-IR, m-calpain and UCP-3 gene polymorphisms and growth traits in Nanyang cattle.
Data describes the long-term changes to skeletal muscle growth and IGF1, 2, 1R, and 2R mRNA expression in progeny after exposure to high and low levels of maternal nutrient intake during the first two trimesters of gestation in the bovine.
Title: Protein intake during gestation affects postnatal bovine skeletal muscle growth and relative expression of IGF1, IGF1R, IGF2 and IGF2R.
Results do not support the premise that increased apoptosis associated with high levels of IGF1 is mediated via downregulation of the IGF1R as previously found in preimplantation mouse embryos.
Title: Increased apoptosis in bovine blastocysts exposed to high levels of IGF1 is not associated with downregulation of the IGF1 receptor.
IGF-I down-regulated functional IGF-I receptor via GSK-3beta inhibition and mTOR activation; constitutive activity of GSK-3beta maintained IGF-I receptor level in nonstimulated cells.
Title: Homologous posttranscriptional regulation of insulin-like growth factor-I receptor level via glycogen synthase kinase-3beta and mammalian target of rapamycin in adrenal chromaffin cells: effect on tau phosphorylation.

Submit: New GeneRIF Correction See all GeneRIFs (18)

General gene information

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Markers

IGF1R (e-PCR)
- UniSTS:278556

IGF1R (e-PCR)
- UniSTS:503091

NLBCMS2 (e-PCR)
- UniSTS:515388

IGF-1ROV (e-PCR)
- UniSTS:251486

IGF-1R (e-PCR), detects polymorphism
- UniSTS:251486

IGF1R (e-PCR)
- UniSTS:519315

TAMU_PKR0001 (e-PCR)
- UniSTS:513725

TAMU_PKR0002 (e-PCR)
- UniSTS:513725

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables insulin receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables insulin receptor substrate binding	IEA Inferred from Electronic Annotation more info	PubMed
enables phosphatidylinositol 3-kinase binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in glucose homeostasis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in multicellular organism development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein autophosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of JNK cascade	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info	PubMed
part_of insulin receptor complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: insulin-like growth factor 1 receptor

Names: IGF-I receptor; insulin-like growth factor I receptor; insulin-like growth factor receptor type 1

NP_001231541.1

EC 2.7.10.1

XP_024837371.1

EC 2.7.10.1

XP_024837373.1

EC 2.7.10.1

XP_059734927.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001244612.1 → NP_001231541.1 insulin-like growth factor 1 receptor precursor

Status: VALIDATED

Source sequence(s)

CV979948, CX952835, EE901083, EH174755, NKLS02000021, X54980

UniProtKB/TrEMBL

A0A3Q1NB49

Related

ENSBTAP00000028690.6, ENSBTAT00000028690.6

Conserved Domains (6) summary

cd05032
Location:992 → 1268

PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases

cd00063
Location:835 → 924

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00064
Location:230 → 277

FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.

pfam00757
Location:175 → 330

Furin-like; Furin-like cysteine rich region

pfam01030
Location:352 → 466

Recep_L_domain; Receptor L domain

pfam07714
Location:999 → 1264

Pkinase_Tyr; Protein tyrosine kinase

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037348.1 Reference ARS-UCD2.0 Primary Assembly

Range

7780293..8087168

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024981603.2 → XP_024837371.1 insulin-like growth factor 1 receptor isoform X1

UniProtKB/TrEMBL

A0A3Q1NB49

Conserved Domains (4) summary

cd05032
Location:871 → 1147

PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases

cd00063
Location:714 → 803

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00757
Location:54 → 209

Furin-like; Furin-like cysteine rich region

pfam01030
Location:231 → 345

Recep_L_domain; Receptor L domain
XM_059878944.1 → XP_059734927.1 insulin-like growth factor 1 receptor isoform X3
XM_024981605.2 → XP_024837373.1 insulin-like growth factor 1 receptor isoform X2

UniProtKB/TrEMBL

A0A3Q1NB49

Conserved Domains (4) summary

cd05032
Location:805 → 1081

PTKc_InsR_like; Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases

cd00063
Location:648 → 737

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00757
Location:24 → 143

Furin-like; Furin-like cysteine rich region

pfam01030
Location:165 → 279

Recep_L_domain; Receptor L domain