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    wat1 TORC1/2 complex WD repeat protein Wat1/Lst8 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540645, updated on 18-Sep-2024

    Summary

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    Official Symbol
    wat1
    Official Full Name
    TORC1/2 complex WD repeat protein Wat1/Lst8
    Primary source
    PomBase:SPBC21B10.05c
    Locus tag
    SPOM_SPBC21B10.05C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    lst8; pop3
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    Genomic context

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    See wat1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (1662941..1664360)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene myosin-binding vezatin family protein Inp2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene vacuolar transporter chaperone (VTC) complex, GTPase regulator subunit Nrf1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Activation of Checkpoint Kinase Chk1 by Reactive Oxygen Species Resulting from Disruption of wat1/pop3 in Schizosaccharomyces pombe. Ahamad N, et al. Genetics, 2016 Dec. PMID 27683273, Free PMC Article
    2. Phosphorylation of Wat1, human Lst8 homolog is critical for the regulation of TORC2 -Gad8 dependent pathway in fission yeast Schizosacchromyces pombe. Ahamad N, et al. Eur J Cell Biol, 2018 May. PMID 29699848
    3. Wat1/pop3, a conserved WD repeat containing protein acts synergistically with checkpoint kinase Chk1 to maintain genome ploidy in fission yeast S. pombe. Verma SK, et al. PLoS One, 2014. PMID 24586893, Free PMC Article
    4. Critical role of Wat1/Pop3 in regulating the TORC1 signalling pathway in fission yeast S. pombe. Panigrahi L, et al. Fungal Genet Biol, 2023 Jan. PMID 36481249
    5. Conserved Wat1/Pop3 WD-repeat protein of fission yeast secures genome stability through microtubule integrity and may be involved in mRNA maturation. Ochotorena IL, et al. J Cell Sci, 2001 Aug. PMID 11686295

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Critical role of Wat1/Pop3 in regulating the TORC1 signalling pathway in fission yeast S. pombe.
      Title: Critical role of Wat1/Pop3 in regulating the TORC1 signalling pathway in fission yeast S. pombe.
    2. In response to osmotic stress Wat1 undergoes hyper-phosphorylation at S116 position. Wat1 interacts with Tor1 and Gad8.
      Title: Phosphorylation of Wat1, human Lst8 homolog is critical for the regulation of TORC2 -Gad8 dependent pathway in fission yeast Schizosacchromyces pombe.
    3. In the absence of wat1, the cells exhibited a high level of nuclear fragmentation. wat1 is required for the regulation of the oxidative stress response. chk1- and wat1-null mutants exhibit conditional synthetic lethality.
      Title: Activation of Checkpoint Kinase Chk1 by Reactive Oxygen Species Resulting from Disruption of wat1/pop3 in Schizosaccharomyces pombe.
    4. The combination of wat1-17 with the chk1 deletion aggravates the defects in the maintenance of fungal genome ploidy.
      Title: Wat1/pop3, a conserved WD repeat containing protein acts synergistically with checkpoint kinase Chk1 to maintain genome ploidy in fission yeast S. pombe.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in TOR signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in TORC1 signaling EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in TORC1 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in TORC2 signaling EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of TORC1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TORC1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of TORC2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TORC2 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    TORC1/2 complex WD repeat protein Wat1/Lst8

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      1662941..1664360
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021577.3 → NP_595682.1  TORC1/2 complex WD repeat protein Wat1/Lst8 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595682.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74184
      Conserved Domains (3) summary
      COG2319
      Location:9 → 301
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:1 → 287
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:44 → 81
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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