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    Inpp5a inositol polyphosphate-5-phosphatase A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365382, updated on 2-Nov-2024

    Summary

    Symbol
    Inpp5aprovided by RGD
    Full Name
    inositol polyphosphate-5-phosphatase Aprovided by RGD
    Primary source
    RGD:1306168
    See related
    EnsemblRapid:ENSRNOG00000017635 AllianceGenome:RGD:1306168
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables inositol-polyphosphate 5-phosphatase activity. Predicted to be involved in negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway. Located in dendrite. Orthologous to human INPP5A (inositol polyphosphate-5-phosphatase A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 402.0), Lung (RPKM 176.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Inpp5a in Genome Data Viewer
    Location:
    1q41
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (203619676..203810035)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (194190086..194380429)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (211732163..211920844)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485195 Neighboring gene uncharacterized LOC134485196 Neighboring gene uncharacterized LOC134485194 Neighboring gene NK6 homeobox 2 Neighboring gene cilia and flagella associated protein 46

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables PH domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables inositol-1,4,5-trisphosphate 5-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables inositol-polyphosphate 5-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables inositol-polyphosphate 5-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables inositol-polyphosphate 5-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    inositol polyphosphate-5-phosphatase A
    Names
    5PTase
    type I inositol 1,4,5-trisphosphate 5-phosphatase
    type I inositol 1,4,5-trisphosphate 5-phosphatase-like
    NP_001102393.1
    XP_006230548.1
    XP_063125749.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108923.2NP_001102393.1  inositol polyphosphate-5-phosphatase A

      See identical proteins and their annotated locations for NP_001102393.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      D3ZZX1
      Related
      ENSRNOP00000051774.2, ENSRNOT00000054890.6
      Conserved Domains (1) summary
      cd09092
      Location:10394
      INPP5A; Type I inositol polyphosphate 5-phosphatase I

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      203619676..203810035
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230486.4XP_006230548.1  inositol polyphosphate-5-phosphatase A isoform X1

      See identical proteins and their annotated locations for XP_006230548.1

      UniProtKB/TrEMBL
      A6HXB9
      Conserved Domains (1) summary
      cd09092
      Location:10394
      INPP5A; Type I inositol polyphosphate 5-phosphatase I
    2. XM_063269679.1XP_063125749.1  inositol polyphosphate-5-phosphatase A isoform X2