Dgcr8 DGCR8, microprocessor complex subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dgcr8provided by MGI
Official Full Name: DGCR8, microprocessor complex subunitprovided by MGI
Primary source: MGI:MGI:2151114
See related: Ensembl:ENSMUSG00000022718 AllianceGenome:MGI:2151114
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gy1; N41; D16Wis2; Vo59c07; mir-1306; D16H22S788E; D16H22S1742E
Summary: Enables primary miRNA binding activity. Acts upstream of or within regulation of stem cell proliferation. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including brain; cardiovascular system; early embryo; facial prominence; and hemolymphoid system. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human DGCR8 (DGCR8 microprocessor complex subunit). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 10.0), CNS E14 (RPKM 9.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A3; 16 11.31 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (18071812..18107115, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (18253948..18289251, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dgcr8 functions in the secondary heart field for outflow tract and right ventricle development in mammals.
Title: Dgcr8 functions in the secondary heart field for outflow tract and right ventricle development in mammals.
RNA-binding protein CCDC137 activates AKT signaling and promotes hepatocellular carcinoma through a novel non-canonical role of DGCR8 in mRNA localization.
Title: RNA-binding protein CCDC137 activates AKT signaling and promotes hepatocellular carcinoma through a novel non-canonical role of DGCR8 in mRNA localization.
Peptidylarginine deiminase 2 regulates expression of DGCR8 affecting miRNA biogenesis in gonadotrope cells.
Title: Peptidylarginine deiminase 2 regulates expression of DGCR8 affecting miRNA biogenesis in gonadotrope cells.
The microRNA processing subunit DGCR8 is required for a T cell-dependent germinal center response.
Title: The microRNA processing subunit DGCR8 is required for a T cell-dependent germinal center response.
The DGCR8 E518K mutation found in Wilms tumors leads to a partial miRNA processing defect that alters gene expression patterns and biological processes.
Title: The DGCR8 E518K mutation found in Wilms tumors leads to a partial miRNA processing defect that alters gene expression patterns and biological processes.
Global miRNA dosage control of embryonic germ layer specification.
Title: Global miRNA dosage control of embryonic germ layer specification.
DGCR8 deficiency impairs macrophage growth and unleashes the interferon response to mycobacteria.
Title: DGCR8 deficiency impairs macrophage growth and unleashes the interferon response to mycobacteria.
Different Cre systems induce differential microRNA landscapes and abnormalities in the female reproductive tracts of Dgcr8 conditional knockout mice.
Title: Different Cre systems induce differential microRNA landscapes and abnormalities in the female reproductive tracts of Dgcr8 conditional knockout mice.
DGCR8 overexpression alleviated hMSC aging and mouse osteoarthritis.
Title: Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis.
The Ddx6 knockout cells were phenotypically and molecularly similar to cells lacking all microRNAs (Dgcr8 knockout ESCs). These data show that the loss of DDX6 can separate the two canonical functions of microRNAs: translational repression and transcript destabilization
Title: Decoupling the impact of microRNAs on translational repression versus RNA degradation in embryonic stem cells.

Submit: New GeneRIF Correction See all GeneRIFs (43)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Gene trapped (2) 1 citation
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:237454 (e-PCR)
- UniSTS:237454

Dgcr8 (e-PCR), detects polymorphism
- UniSTS:265703

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables double-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded RNA binding	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables primary miRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables primary miRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables primary miRNA binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-RNA adaptor activity	IEA Inferred from Electronic Annotation more info
enables protein-RNA adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of pre-miRNA processing	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of pre-miRNA processing	ISO Inferred from Sequence Orthology more info
involved_in primary miRNA processing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within primary miRNA processing	ISO Inferred from Sequence Orthology more info
involved_in primary miRNA processing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
part_of microprocessor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of microprocessor complex	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IEP Inferred from Expression Pattern more info	PubMed

General protein information

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Preferred Names: microprocessor complex subunit DGCR8

Names: DiGeorge syndrome critical region gene 8; diGeorge syndrome critical region 8 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_033324.2 → NP_201581.2 microprocessor complex subunit DGCR8

See identical proteins and their annotated locations for NP_201581.2

Status: VALIDATED

Source sequence(s)

AB086857

Consensus CDS

CCDS28018.1

UniProtKB/Swiss-Prot

Q9EQM6

Related

ENSMUSP00000009321.5, ENSMUST00000009321.11

Conserved Domains (3) summary

smart00456
Location:302 → 332

WW; Domain with 2 conserved Trp (W) residues

cd19867
Location:505 → 578

DSRM_DGCR8_rpt1; first double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins

cd19868
Location:618 → 686

DSRM_DGCR8_rpt2; second double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

18071812..18107115 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006522795.3 → XP_006522858.1 microprocessor complex subunit DGCR8 isoform X1

See identical proteins and their annotated locations for XP_006522858.1

Conserved Domains (3) summary

smart00456
Location:302 → 332

WW; Domain with 2 conserved Trp (W) residues

cd19867
Location:505 → 578

DSRM_DGCR8_rpt1; first double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins

cd19868
Location:639 → 707

DSRM_DGCR8_rpt2; second double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins
XM_030249355.2 → XP_030105215.1 microprocessor complex subunit DGCR8 isoform X2

UniProtKB/Swiss-Prot

Q9EQM6

Conserved Domains (3) summary

smart00456
Location:302 → 332

WW; Domain with 2 conserved Trp (W) residues

cd19867
Location:505 → 578

DSRM_DGCR8_rpt1; first double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins

cd19868
Location:618 → 686

DSRM_DGCR8_rpt2; second double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins
XM_030249354.2 → XP_030105214.1 microprocessor complex subunit DGCR8 isoform X1

Conserved Domains (3) summary

smart00456
Location:302 → 332

WW; Domain with 2 conserved Trp (W) residues

cd19867
Location:505 → 578

DSRM_DGCR8_rpt1; first double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins

cd19868
Location:639 → 707

DSRM_DGCR8_rpt2; second double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins
XM_030249352.1 → XP_030105212.1 microprocessor complex subunit DGCR8 isoform X1

Conserved Domains (3) summary

smart00456
Location:302 → 332

WW; Domain with 2 conserved Trp (W) residues

cd19867
Location:505 → 578

DSRM_DGCR8_rpt1; first double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins

cd19868
Location:639 → 707

DSRM_DGCR8_rpt2; second double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins
XM_030249353.1 → XP_030105213.1 microprocessor complex subunit DGCR8 isoform X1

Conserved Domains (3) summary

smart00456
Location:302 → 332

WW; Domain with 2 conserved Trp (W) residues

cd19867
Location:505 → 578

DSRM_DGCR8_rpt1; first double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins

cd19868
Location:639 → 707

DSRM_DGCR8_rpt2; second double-stranded RNA binding motif of DiGeorge syndrome critical region 8 (DGCR8) and similar proteins